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Biomedical subjects

A S Martinez

Publications and source records attributed to A S Martinez.

9 recordsLinked to original sources
PubMed2001

Deterministic walks in random media.

Deterministic walks over a random set of N points in one and two dimensions ( d = 1,2) are considered. Points ("cities") are randomly scattered in R(d) following a uniform distribution. A walker ("tourist"), at each time step, goes to the nearest neighbor city that has not been visited in the past tau steps. Each initial city leads to a different trajectory composed of a transient part and a final p-cycle attractor. Transient times (for d = 1,2) follow an exponential law with a tau-dependent decay time but the density of p cycles can be approximately described by D(p)proportional to p(-alpha(tau)). For tau>>1 and tau/N<<1, the exponent is independent of tau. Some analytical results are given for the d = 1 case.

Journal Article↗
PubMed2001

Hydromineral regulation in the hydrothermal vent crab Bythograea thermydron.

This study investigates the salinity tolerance and the pattern of osmotic and ionic regulation of Bythograea thermydron Williams, 1980, a brachyuran crab endemic to the deep-sea hydrothermal vent habitat. Salinities of 33 per thousand-35 per thousand were measured in the seawater surrounding the captured specimens. B. thermydron is a marine stenohaline osmoconformer, which tolerates salinities ranging between about 31 per thousand and 42 per thousand. The time of osmotic adaptation after a sudden decrease in external salinity is about 15-24 h, which is relatively short for a brachyuran crab. In the range of tolerable salinities, it exhibits an iso-osmotic regulation, which is not affected by changes in hydrostatic pressure, and an iso-ionic regulation for Na(+) and Cl(-). The hemolymph Ca(2+) concentration is slightly hyper-regulated, K(+) concentration is slightly hyper-hypo-regulated, and Mg(2+) concentration is strongly hypo-regulated. These findings probably reflect a high permeability of the teguments to water and ions. In addition to limited information about salinity around hydrothermal vents, these results lead to the hypothesis that B. thermydron lives in a habitat of stable seawater salinity. The osmoconformity of this species is briefly discussed in relation to its potential phylogeny.

Animals↗
PubMed2000

Vanishing of energy transport velocity and diffusion constant of electromagnetic waves in disordered magnetic media.

The energy transport velocity v(E) and the diffusion constant D of electromagnetic waves in the presence of randomly distributed ferromagnetic scatterers are studied. v(E) presents a strong dependence on the relative magnetic permeability mu and, unlike the nonmagnetic case, exhibits sharp drops in the small-particle limit and never coincides with the phase velocity v(p). Both v(E) and D exhibit an oscillatory dependence on mu and vanish for certain values of mu. Since mu of ferromagnetic scatterers strongly depends on the temperature and applied magnetic field, we suggest that these facts can be explored in technological applications.

Journal Article↗
PubMed2000

Speech recognition with reduced spectral cues as a function of age.

Adult listeners are able to recognize speech even under conditions of severe spectral degradation. To assess the developmental time course of this robust pattern recognition, speech recognition was measured in two groups of children (5-7 and 10-12 years of age) as a function of the degree of spectral resolution. Results were compared to recognition performance of adults listening to the same materials and conditions. The spectral detail was systematically manipulated using a noise-band vocoder in which filtered noise bands were modulated by the amplitude envelope from the same spectral bands in speech. Performance scores between adults and older children did not differ statistically, whereas scores by younger children were significantly lower; they required more spectral resolution to perform at the same level as adults and older children. Part of the deficit in younger children was due to their inability to utilize fully the sensory information, and part was due to their incomplete linguistic/cognitive development. The fact that young children cannot recognize spectrally degraded speech as well as adults suggests that a long learning period is required for robust acoustic pattern recognition. These findings have implications for the application of auditory sensory devices for young children with early-onset hearing loss.

Adult↗
PubMed1998

Subjective judgements of clarity and intelligibility for filtered stimuli with equivalent speech intelligibility index predictions.

The purpose of this investigation was to determine whether subjective judgments of clarity or intelligibility would be rated equally among conditions in which speech was equated for predicted intelligibility (using the Speech Intelligibility Index, SII) but varied in bandwidth. Twenty listeners with normal hearing rated clarity and intelligibility for sentence material (Hearing In Noise Test) in speech-shaped noise at six paired low- and high-pass filtered conditions in which SII was equated for each pair. For three paired conditions, predicted intelligibility increased as SII increased monotonically (0.3, 0.4, 0.5). In the remaining paired conditions, SII continued to increase monotonically (0.6, 0.7, 0.8) but predicted intelligibility was held at a maximal level (> or = 95%). Predicted intelligibility was estimated from the transfer function relating SII to speech recognition scores determined in preliminary experiments. Differences in ratings between paired low- and high-pass filtered sentences did not reach statistical significance for either clarity or intelligibility, indicating that the spectral differences at equivalent SIIs did not influence the judgments for either of the two dimensions. For conditions in which predicted intelligibility increased, both clarity and intelligibility ratings increased in a similar manner. For conditions in which predicted intelligibility was maximized, intelligibility ratings remained the same statistically across conditions while clarity ratings changed modestly. Although high correlations were observed between clarity and intelligibility ratings, intelligibility ratings were consistently higher than clarity ratings for comparable conditions. The results indicated that listeners with normal hearing produced clarity and intelligibility ratings for the same speech material and experimental conditions that were highly related but differed in magnitude. Caution is required when substituting clarity for intelligibility.

Adolescent↗
PubMed1993

Detection of autoantibodies against hGH in sera of idiopathic hypopituitary children.

Using reliable displacement radiobinding assay (RBA) and ELISA, the existence of anti-human growth hormone autoantibodies (hGHAA) was confirmed in idiopathic hypopituitary patients with growth impairment. Six of 35 hypopituitary patients (17.1%) and 1/85 (1.2%) control children proved positive for hGHAA by RBA (>control mean + 3 SD). IgG isotype-hGHAA by ELISAIgG (> control mean + 3 SD) were positive for 6/34 (17.7%) and 3/85 (3.5% hypopituitary and control children, respectively. Due to an asymmetry to the right of the ELISAIgG distribution, an alternative cutoff based on a nonparametric method was obtained, and positive results for hypopituitary children increased to 10/34 (29.4%). Three of 34 hypopituitary patients but no control children were positive for hGHAA of IgM isotype. The hGHAA were detected in children with or without perinatal problems. These autoantibodies may represent markers of a major autoimmune process involving a portion of the anterior pituitary and may contribute to the development of hypopituitarism in over 15% of hypopituitary children.

Adolescent↗
PubMed1991

New observations on midline defects: coincidence of anophthalmos, microphthalmos and cryptophthalmos with hypothalamic disorders.

Four children with severe congenital eye anomalies are described of which three had related symptoms. Two had bilateral anophthalmia, the optic nerves not detectable by computed cranial tomography and magnetic resonance imaging, and the third child had bilateral microphthalmia and coloboma iridis. The fourth patient had bilateral cryptophthalmia as part of Fraser syndrome. All four patients were of small stature. In three of them growth hormone deficiency was demonstrated which was of hypothalamic origin as shown by growth hormone releasing hormone tests. In the fourth child hypogonadotropic hypogonadism and tertiary thyroid deficiency were diagnosed which responded well to thyroxine treatment. Pathogenetically the described disorders are due to congenital defects of midline structures as a common "developmental field".

Abnormalities, Multiple↗