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Biomedical subjects

A S Pacsa

Publications and source records attributed to A S Pacsa.

6 recordsLinked to original sources
PubMed1977

Impairment of immunity during pregnancy and antiviral effect of amniotic fluid.

In 297 pregnant women serum-levels of antibody to rubella virus were determined by haemagglutination inhibition, and serum-levels of antibodies to herpes-simplex virus and Toxoplasma gondii were measured by indirect immunofluorescence tests. Sera of age-matched non-pregnant women with intrauterine devices were also tested for the antibodies. A lower level of humoral immunity was found in the pregnant women than in the controls, and this fell further as pregnancy progressed. Investigation of serum-samples taken at 14 weeks' gestation, at delivery, and 30-45 days post-partum revealed that after delivery humoral immunity to rubella virus returned to the levels of early gestation. Of 44 amniotic-fluid samples collected from pregnancies terminated at 11-14 wk and examined for antiviral activity to herpes-simplex virus and polio-virus, 7 exerted an antiviral effect which could be linked with the protein (other than alpha1-fetoprotein) fraction of the amniotic fluid.

Amniotic Fluid↗
PubMed1976

Herpes simplex virus-specific antigens in exfoliated cervical cells from women with and without cervical anaplasia.

By the indirect immunofluorescence technique the presence of herpes simplex virus-specific antigens was investigated in cervical cells of 530 women with normal cervical epithelium, 175 with bland disorders, 52 with dysplasias, and 38 with invasive cervical carcinomas of the uterine cervix. Antigens were present in 9% of samples from women with normal cervical epithelium; they were present in 41% of the samples from women with bland disorders, 61% of those from dysplasia patients, and 94% of those from invasive carcinoma patients. The testing of 3 consecutive imprints of 68 antigen-positive and 232 antigen-negative women at 6-month intervals revealed that, in cervical cells, herpesvirus-specific antigens persisted throughout the 1-year period of the follow-up.

Adult↗
PubMed1975

Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls.

Antibody activity to herpesvirus hominis type 2 (HVH-2) in 151 women cured of cervical carcinoma (60 in situ, 91 invasive) and in 106 controls differed significantly, especially between the in situ (73%) and control (17%) groups. Sera of 57 patients with cervical atypia showed an increased antibody activity to HVH-2 (58%), compared with that of the 57 matched controls (23%). Antibodies to cytomegalovirus (CMV) were detected more frequently in sera of women with atypia (61%) than in sera of women with cervical disorders other than atypia (42%) or in sera of healthy controls (33%). HVH antigens were present in cervical cells from patients with atypia and from matched controls. Not only exfoliated (imprints) but also cultured and cocultured cervical cells contained HVH antigens; there was no correlation between antigen positivity and antibody activity to HVH-2. Our data further supported the association between HVH-2 and cervical anaplasia and indicated that CMV may also be implicated in its etiology.

Adult↗