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Biomedical subjects

A S Rockoff

Publications and source records attributed to A S Rockoff.

6 recordsLinked to original sources

Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole.

Treatment of chronic mucocutaneous candidiasis has included drugs, immunotherapy, and replacement of nutritional and endocrine deficiency. Although amphotericin B is the best known and most commonly used form of treatment, the imidazole antibiotic clotrimazole has shown promise as an effective agent that can be given orally with low toxicity. A 9-year-old girl responded to intermittent clotrimazole therapy with complete and prolonged remission. This form of treatment offers advantages in safety and effectiveness over other therapies for chronic mucocutaneous candidiasis.

Administration, Oral↗

Fungus cultures in a pediatric outpatient clinic.

Comparison of culture results with clinical impressions showed that pediatric house officers made frequent errors in diagnosing superficial fungus infections. Results of cultures on dermatophyte test medium (DTM), read by nonmycologists in the clinic, were comparably accurate with those on standard media processed in a laboratory. DTM is a useful aid in diagnosing dermatophytoses and teaching clinical mycology to pediatric residents.

Arthrodermataceae↗

Myocardial necrosis following general anesthesia in hemoglobin SC disease.

A 4-year-old girl with hemoglobin SC disease died following general anesthesia. Autopsy showed widespread intravascular sickling; staining with hematoxylin-basic fuchsin-picric acid demonstrated newly developed massive myocardial necrosis, a rarely documented finding. Anesthesia may produce conditions that provoke "crises" in patients with sickle hemoglobinopathies. Preoperative identification of sickle states and careful attention to hydration and oxygenation may minimize anesthetic risks in these patients.

Anemia, Sickle Cell↗

Camphor dangers.

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Camphor↗