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Biomedical subjects

A S Sadykov

Publications and source records attributed to A S Sadykov.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[A new interferon inducer active via peroral administration].

Biological activities of a new oral interferon inducer, Tash-4, were studied. In maximal soluble doses (2000 mg/kg body weight) the inducer was shown to have no toxicity. An important advantage of Tash-4 over other known interferon inducers consists in its capacity to induce interferon in high concentrations in the intestinal tract. Upon repeated administration of Tash-4 hyporeactivity is detectable within 3 days and persists for up to 6 days. A change of inducers may be used to overcome the hyporeactivity. Sequential administration of Tash-4 and Tash-3 induced in animals interferon production in response first to one inducer, then to the other. It is assumed that the mechanisms of induction and suppression of interferon induced by these preparations differ.

Administration, Oral↗
PubMedDate not supplied

[Effect of the phase state of lipids on their interaction with cobra cytotoxin].

Interaction between cytotoxin of the Central Asia cobra venom and dimiristoylphosphatidylcholine bilayer depending on its phase state was studied by ESR with spin label. A conclusion can be drawn that the efficiency of cytotoxin effect on the membranes depends on their phase state. Cytotoxin molecules are incorporated into myophile region of the bilayer, only if the latter is in the liquid crystal state. The interaction between cytotoxins and lipids of the bilayer in a gel state is in the main conditioned by electrostatic forces.

Cytotoxins↗