PubMed Health⌕ Search

Biomedical subjects

A S Saran

Publications and source records attributed to A S Saran.

5 recordsLinked to original sources
PubMed1986

EEG observations during combined haloperidol-lithium treatment.

Some reports have indicated a neurotoxic interaction of haloperidol and lithium, whereas others have not found this interaction. This is a report on two patients who showed both photomyoclonic and photoparoxysmal responses while on combined lithium-haloperidol treatment. We suggest that these findings, which have not been previously reported to be associated with combined lithium-haloperidol treatment, reflect neurotoxicity and that electroencephalogram (EEG) monitoring should be done on patients receiving this combined medication regimen.

Adult↗
PubMed1986

Use or abuse of antiparkinsonian drugs by psychiatric patients.

The abuse of antiparkinsonian drugs was investigated in 108 aftercare patients receiving both neuroleptics and antiparkinsonian drugs. Seventy-six patients who did not show clinical extrapyramidal symptoms (EPS) were asked to reduce the dose by half or to discontinue their antiparkinsonian drug. Of these, 27 were experiencing mild EPS (subclinical) at baseline and showed reluctance or refused to reduce or discontinue their antiparkinsonian drug. Of the remaining 49 patients, 24 agreed to reduce the dose by half, and 25 agreed to discontinue their antiparkinsonian drug. During 12 weeks of follow-up, 75% of the reduced dosage group and 62.5% of the discontinued group developed clinical EPS. Nine patients (18.3%) dropped out of treatment. These results suggest that patients without clinical EPS may still experience uncomfortable symptoms (subclinical EPS), and that this is related to their desire to continue taking antiparkinsonian drugs. Antiparkinsonian drug abuse was not seen in this patient population. It is suggested that discontinuation of antiparkinsonian drugs may lead to premature termination of treatment.

Aftercare↗
PubMed1985

Depression after minor closed head injury: role of dexamethasone suppression test and antidepressants.

The results of dexamethasone suppression test (DST) and the effectiveness of amitriptyline and phenelzine in treating depression with melancholia after minor closed head injury in 10 patients were compared to those in 12 control patients with primary depression and melancholia. Prevalence of abnormal DST results was higher in the control group (91%) than in the closed head injury group (10%). Results of the DST corresponded with clinical improvement. Amitriptyline produced significant and consistent improvement in all control patients at the end of 4 weeks of treatment. No patient in the closed head injury group showed significant improvement with amitriptyline. The closed head injury patients were treated with phenelzine after a 3- to 7-day washout period. No statistical improvement after 4 weeks of treatment with phenelzine was seen in any of these patients. The DST may be useful as an adjunct to the diagnostic and monitoring process in primary depression with melancholia. Depression after minor closed head injury did not correlate with the DST. Amitriptyline and phenelzine have limited use (if any) in depression with melancholia after minor closed head injury.

Adult↗
PubMed1982

Antidiabetic effects of lithium.

Lithium carbonate was administered to a female manic depressive patient who also had maturity onset diabetes mellitus. She was found to have lowered blood glucose levels with administration of lithium without change in the other variables which could effect blood glucose levels. In could be concluded that lithium carbonate had antidiabetic effects in this case.

Bipolar Disorder↗