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Biomedical subjects

A S Sharykin

Publications and source records attributed to A S Sharykin.

At least 19 recordsLinked to original sources
PubMed2002

[Hematological characteristics in blood autoanalysis in children with congenital heart defects].

Hematological status of infants with congenital heart disease (CHD) was evaluated by automated systems. Blood analyses were carried out in 40 infants with the pale type and in 20 with the blue type CHD. Increased erythrocyte count and hematocrit were detected in the blue type CHD. Evaluation of the leukocytic formula showed correlation of the results of automated analysis and microscopic analysis of a blood smear. Automated method is preferable for estimating platelet count. Platelet count was decreased and the cells were larger in patients with the blue type disease in comparison with the pale type group. Hence, automated analyzer gives a wide spectrum of blood values with high accuracy and productivity and helps evaluate hemopoiesis in patients with CHD.

Autoanalysis↗
PubMed1992

[The use of polytetrafluoroethylene vascular prostheses (Gore-Tex) for subclavian-pulmonary anastomosis in children with tetralogy of Fallot].

The paper provides the results of a modified subclavian pulmonary anastomosis by employing Gore-Tex vascular prostheses in 91 babies with Fallot's tetrad whose age was 10 days to 32 months and weight was 3.6 to 15 kg. In 89 patients, the operation was performed by using a prosthesis, 4-6 mm in diameter, without crossing the subclavian artery, whereas in 2 patients, this was done by lengthening the crossed short subclavian artery. In the early postoperative period, 2 (2.2%) patients died, anastomosis thrombosis requiring a reoperation, occurred in 3 (3.3%) patients; other non-fatal complications were observed in 8 (8.8%) patients. A clear-cut effect of the operation was seen in all patients. SaO2 rose from 54 +/- 18 to 80.0 +/- 8%. In the long-term (6-60 months) postoperative periods, a total of 77 patients were examined: anastomosis function proved to be impaired in 4 (5.2%), all the vascular prostheses, 6 mm in diameter, were patent up to 60 months of surgery. The thrombosis probability for anastomosis, 5 mm in diameter, was 5% during 12 months of operation and 16% during 24-60 months. Three patients needed therapeutical management of heart failure. Other serious complications, including deformity of the pulmonary artery or upper extremity, were not found in the examinees. In the palliative treatment of Fallot's tetrad, subclavian pulmonary anastomosis via the Gore-Tex vascular prosthesis can be the method of choice in the first-year-old infants and has some substantial advantages over the classical Blelock-Taussig anastomosis.

Blood Vessel Prosthesis↗
PubMed1992

[The results of the surgical treatment of aortic coarctation in nursing infants with a sharp decrease in left ventricular pumping function].

Two-dimensional echocardiography was conducted in 24 patients, aged from 14 days to 12 months, suffering from coarctation of the aorta (CA) with the left ventricular (LV) ejection fraction (EF) less than 30%. The symptom of LV fibroelastosis was found in only 16.7% of patients. In the first 7 days after correction of CA the LV end-systolic volume reduced by 20% and the EF increased by 1.5 times, which may be explained by removal of LV post-loading. The values of the LV pumping function improved in the late periods due to restoration of myocardial contractility. In infants operated on in the first 3 months of life the dynamics was more favorable, the EF reached 68 +/- 3.8% while in those operated on after the age of 3 months it reached only 50.8 +/- 2.5% (p < 0.05). The authors discuss problems of compensatory hypertrophy and myocardial contractile capacity as the main mechanisms responsible for LV pumping function in CA.

Aortic Coarctation↗
PubMed1991

[Evaluation of peripheral circulation in infants with aortic coarctation by transcutaneous pO2 measurement].

Fourteen patients 6 weeks to 8 months of age with coarctation of the aorta (CA) were examined before and after correction of the anomaly. In inspiration of increasing concentrations of O2 the TavO2 was progressively delayed below CA as compared to the region above CA, which reflected latent tissue oxygen deficiency. After CA correction the TavO2 values were practically the same in both regions. Measurement of TavO2 at two points during inspiration of increased O2 concentrations (0.65) may be an objective method for confirming the existence of CA in infants.

Aortic Coarctation↗
PubMed1985

[Analysis of hospital mortality of patients with congenital heart defects in the 1st year of life].

Causes of mortality were analysed in a group of 122 patients with congenital heart disease in their first year of life following conservative management, closed surgery and operations under assisted circulation. Fatal outcomes were predetermined by a severe congenital defect in 18.2% of the patients, while in the remaining cases they could basically have been prevented by means of a timely primary diagnosis and referral to a specialized clinical institution, accurate topical diagnosis, correct assessment of the severity of the patients' condition and improved post-operative intensive care.

Heart Defects, Congenital↗
PubMed1977

[Thromboembolic complications after aortic valve prosthesis].

The presented analysis covers the results of aortic valve replacement in 155 patients followed-up for 1 to 11 years after surgery. Actuarial statistics permitted to reveal the dynamics of survival and of good results of different institutions. No anticoagulation whatsoever was given to 85 patients, while 70 others received Phenylin, 30-60 mg/day. Thromboembolism was found to be the leading complication affecting the survival rate and the stability of good results in the late postoperative period. Among the patients receiving no anticoagulants the incidence of thromboembolism proved significantly higher than among those treated with Phenylin.

Adolescent↗
PubMedDate not supplied

[Morphofunctional analysis of right ventricle cardiomyocytes in patients with Fallot's tetrad during first year of life].

Material of intrasurgical biopsies of the right ventricular (RV) myocardium of 28 patients with Fallot's tetrad was studied with light and electron microscopy. RV cardiomyocytes were hypertrophic and showed signs of growth and differentiation. Myofibrillogenesis intensity directly correlated with the pressure gradient between RV and pulmonary artery. At the same time there was a structural alteration of mitochondria and formation of a specialized population of intermyofibrillar mitochondria. Continuing myofibrillogenesis in cardiomyocytes may be one of the causes of decreased myocardial contractility.

Heart Ventricles↗