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Biomedical subjects

A S Shevchenko

Publications and source records attributed to A S Shevchenko.

At least 19 recordsLinked to original sources
PubMed1998

[Organizational and economic aspects of psychiatry].

The main trends in the organization and economic transformations in psychiatric services of Russia in 1989-1996 are analyzed: financial support of the institutions of psychiatric care, changes in the organizational structure of services, new forms and types of care. The opinion of the authorities of regional services concerning the organization and economic changes in institutions of psychiatric care are presented.

Costs and Cost Analysis↗
PubMed1997

Natural hidden antibodies reacting with DNA or cardiolipin bind to thymocytes and evoke their death.

Both free and hidden natural antibodies to DNA or cardiolipin were obtained from immunoglobulins of a normal donor. The free antibodies reacting with DNA or cardiolipin were isolated by means of affinity chromatography. Antibodies occurring in an hidden state were disengaged from the depleted immunoglobulins by ion-exchange chromatography and were then affinity-isolated on DNA or cardiolipin sorbents. We used flow cytometry to study the ability of free and hidden antibodies to bind to rat thymocytes. Simultaneously, plasma membrane integrity was tested by propidium iodide (PI) exclusion. The hidden antibodies reacted with 65.2 +/- 10.9% of the thymocytes and caused a fast plasma membrane disruption. Cells (28.7 +/- 7.1%) were stained with PI after incubation with the hidden antibodies for 1 h. The free antibodies bound to a very small fraction of the thymocytes and did not evoke death as compared to control without antibodies. The possible reason for the observed effects is difference in reactivity of the free and hidden antibodies to phospholipids. While free antibodies reacted preferentially with phosphotidylcholine, hidden antibodies reacted with cardiolipin and phosphotidylserine.

Animals↗
PubMed1990

[The treatment of acute cholecystitis].

The authors treated 462 patients with acute cholecystitis. Operated on were 220 patients. Of them, 53.6%--at the first 24 hours after admission. In 26.3% of the patients, peritonitis was an indication for the operation. The postoperative lethality was 4.1%.

Acute Disease↗