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Biomedical subjects

A S Shevelev

Publications and source records attributed to A S Shevelev.

At least 19 recordsLinked to original sources
PubMed1976

[Suppression of interferon synthesis during the "graft-versus-host" reaction in F1(CBAXC57BL/6) mice].

The development of the graft-versus-host reaction (GVHR) in the F1(1CBA X C57BL/6 hybrid mice after the transplantation of spleen cells from the C57BL/6 parent donor resulted in a strong inhibition of the serum interferon production induced by the intraperitoneal injection of the Newcastle disease virus. In vitro with the mouse bone marrow cells during the development of the GVHR the interferon response was first reduced and then disappeared completely. The described phenomenon could therefore serve as an index of the development of the GVHR.

Animals↗
PubMed1975

[Reciprocal influence of the graft vs. host reaction and pregnancy].

The graft versus host reaction (GVHR) was induced in mouse females-hybrids F1 (CBA X C57BL/6) by intravenous injection of suspension of the lymphoid cells of the spleen and of lymphoid nodes from C57BL/6 mouse females. Pregnancy resulted from interbreeding of the test females with syngenic males 1--5 days before, and 1--10, 10--20, 30--40 and more than 40 days after the moment of the lymphoid cells injection, aggravated the GVHR induced transplantation disease. At the same time the GVHR under these conditions decreased the percentage of pregnant animals and brought to child-bearing disfunction of the test animals (stillbirth, death of pregnant females, miscarriage). In some of the test mice aggravation of the GVHR was observed after delivery. Survival of the progeny decreased.

Animals↗