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Biomedical subjects

A S Sorokin

Publications and source records attributed to A S Sorokin.

At least 19 recordsLinked to original sources
PubMed1992

[Contents of aldosterone and electrolytes in blood plasma and the myocardium of rats after single physical exertion during acute alcoholic intoxication].

It was proved in experiments with male Wistar rats that acute alcohol intoxication caused significant changes in electrolytes balance in blood plasma and myocardium remaining for a long time after ethanol injection. SPL test makes it possible to reveal inadequate reaction of blood plasma aldosterone in alcohol injected rats. This fact may be considered as the fact of involving extracardiac component of compensation of myocardial functional insufficiency conditioned mainly by electrolyte unbalance. The tolerance to physical loading is significantly higher in alcohol injected rats than in intact animals.

Alcoholic Intoxication↗
PubMed1992

[Aldosterone and electrolyte content in blood and myocardium of rats after single physical load in acute alcoholic intoxication].

It is shown that acute alcoholic intoxication causes essential changes of aldosterone content and balance of electrolytes in blood plasma of Wistar rat males. The SPL test revealed the inadequate reaction in the mineral-corticoid function of the adrenal glands in the rats with acute alcoholic intoxication. The method of the free choice of the load by the experimental rats is the most optimal way to assess. The rats with acute alcoholic intoxication displayed smaller tolerance to physical load.

Acute Disease↗
PubMed1991

[Corticoid secretion and patho-histological changes in the adrenal glands in hypertension].

Hydrocortisone, 11-hydroxycorticosteroids and aldosterone were measured in 74 patients with a history of surgery on the sympathoadrenal system for stable essential hypertension. Morphologic structure of the sympathetic ganglia of the celiac plexus and adrenals removed during surgery was under study. The studies have revealed a relationship between pathohistologic changes in operation material and adrenocortical functional activity. The authors suggest a possibility of a relationship between morphofunctional changes in the adrenals and sympathetic ganglia, and enhanced nervous system efferent effects with the progress of the disease.

11-Hydroxycorticosteroids↗
PubMed1990

[A study of immunologic reactions using biophysical methods].

Chemiluminescent characteristics of the antigen-antibody reaction, effects of gamma-globulin, iodine, hydrogen peroxide, and temperature on the type of the fluorescence of the complex were examined with the use of biomedical chemiluminometer and fluorescent spectrophotometer (Japan). The findings evidence that fluorescence is connected mainly with the tryptophan amino acid residues and with conformational restructuring of protein molecules. Changes in the intensity of chemiluminescence during the formation of a complex may be used for the detection of antibodies in the examinee's body.

Animals↗
PubMed1986

[Diagnosis of vascular cholecystitis by sequential analysis].

Based on an analysis of the examination of 106 patients with acute cholecystitis the author describes specific features of some parameters of dermatoglyphics and group relevance of blood in patients with different forms of acute (vascular included) cholecystitis.

ABO Blood-Group System↗
PubMed1983

[Dynamics of the level of insulin in blood in response to hydrocortisone loading in myocardial infarction].

To elucidate the details of carbohydrate metabolism in the course of acute myocardial infarction, baseline blood insulin and glucose levels and changes thereof in response to acute hydrocortisone loading were investigated in patients with acute transmural and large-focal myocardial infarction that had developed in the presence of essential hypertension (patients with diabetes mellitus were excluded from the study). Basal hypoinsulinemia was discovered on Day 1 of myocardial infarction in these patients. On Days 3-5 of infarction, blood insulin concentration was increased significantly. The pattern of hydrocortisone-induced changes in glucose level suggests glucocorticoid involvement in "urgent" glucose mobilization. The state of and associations between the two hormonal systems throughout acute myocardial infarction are discussed on the basis of changes in insulin and glucose levels under hydrocortisone load.

Adult↗
PubMed1983

[Aldosterone, sodium and potassium concentrations in the blood of patients with myocardial infarction after acute hydrocortisone load].

Patients with acute myocardial infarction were repeatedly investigated in the course of their disease. Blood aldosterone was assayed radioimmunologically to determine its baseline level and response to the acute hydrocortisone load test. Cases where acute myocardial infarction was combined with essential hypertension were characterized by high blood aldosterone baseline, as were cases with circulatory insufficiency developing at the acute stage of infarction. Pattern of aldosterone variation in response to hydrocortisone administration was dependent on the phase of infarction and provided indirect evidence of glucocorticoid activity at various dates of the disease. The acute stage was associated with hyperaldosteronemia.

Adult↗
PubMed1983

[Dynamics of the structural organization of the liver parenchymal cells in induced autophagocytosis].

The volume of hepatocytes, their nuclei, cytoplasm, relative and absolute volumes, surface area, number and average volume of cytoplasmic structures have been studied in male mice C57B1 (2-month-old with body mass 19-21 g), 20, 60 min and 72 h after glucagon with glycine buffer in the dose 10 mcg per 100 g of body mass has been injected intraperitoneally. A reverse dependence between glycogen contents and a total volume of cytosegresomes, residual bodies and autophagolysosomes in the hepatic parenchyma is revealed. Acid phosphatase free activity, when hepatic homogenates are treated in 0.25 M and 0.15 M saccharose solutions, is the highest 60 min after glucagon administration. At that time hepatocytes do not contain any glycogen, and volume and number of lysosomes, especially the secondary ones are the greatest. Meanwhile, the total volume of the autophage structures is 150 times as great as the control one. In 60 min the volume of hepatocytes increases nearly by 50%, total volume and number of ultrastructures, especially that of free ribosomes, increase sharply. In 20 min concentration of 11-oxycorticosteroid hormones in blood more than 3 time exceeds the control level. The effect of glucagon dependent on cyclic adenosinmonophosphate is probably realized by means of an enhanced glycogenolysis and an increased level of metabolic processes in the hepatocytes. This causes a deficit of energy substrates, which could, to some extent, be compensated at the expense of reutilization of the lysosomal hydrolysis products.

Animals↗