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Biomedical subjects

A S Swarup

Publications and source records attributed to A S Swarup.

8 recordsLinked to original sources
PubMed1998

Potential role of NF-kB and RXR beta like proteins in interferon induced HLA class I and beta globin gene transcription in K562 erythroleukaemia cells.

Positive effects of biological response modifiers on cancer cells are usually measured using markers for increased immunogenicity as well as those for increased differentiation of the cells. An increase in levels of HLA class I antigens and the adult (beta) globin molecules are two such markers that may be used to assess the effect of modulators like interferons on the K562 erythroleukaemia cell line. Although interferon mediated up regulation of gene expression is thought to be primarily regulated by binding of proteins to the Interferon responsive cis elements in the promoters of IFN responsive genes, recent evidence has shown the induction of other transcriptional activators in response to IFN treatment. We present evidence for one such instance wherein up regulation of HLA class I and beta globin gene transcription are accompanied by induction of binding activities similar to RXR beta and kB proteins in K562 cells.

Animals↗
PubMed1987

Management of traumatic rupture of the diaphragm.

Traumatic rupture of the diaphragm is a potentially serious injury which presents in different forms depending on the mechanism of the causative trauma. Over a 7 year period, 20 patients (17 male and 3 female) with traumatic rupture of the diaphragm were seen in our unit; their mean age was 25.6 years. Automobile accidents caused the diaphragmatic injuries in 65 per cent of cases while falls from trees were the cause of injury in 10 per cent. Ten patients (50 per cent) were seen within 7 days of the injury and 95 per cent within 3 months. The left hemidiaphragm was ruptured in 85 per cent and the right in 15 per cent of cases. Fifty ribs were fractured in fourteen patients (70 per cent) but there were no pelvic fractures. Fourteen patients (70 per cent) had gastrointestinal visceral herniation into the thorax, the stomach, omentum, colon and spleen being the commonest herniating organs. Successful surgical repair was achieved in 18 patients, 4 of whom also had splenectomy; 2 patients were treated conservatively. A high index of suspicion and early surgical treatment are the mainstay of successful management of traumatic rupture of the diaphragm with or without herniation of abdominal organs.

Accidents, Traffic↗
PubMed1982

Experience with civilian vascular injuries in eastern Nigeria.

Accidents and trauma are the most common causes of death in the young Nigerian male. Due to inadequate facilities for recovering the injured, patients with major vascular injuries fail to reach the hospital alive. The incidence of vascular injury in the Nigerian population should be higher than is reflected in this study. Late presentation to the hospital results in the greater number of patients with traumatic aneurysms. Improvement in ambulance and hospital services for the injured will facilitate earlier detection and treatment of vascular injuries, improve the mortality rate, and limit the late sequelae of vascular injuries.

Accidents, Traffic↗
PubMed1981

Chest trauma in a developing country.

In a developing country with inadequate clinical facilities a conservative method of management of a major clinical problem is often the only rational approach. This policy was adopted in the management of 145 patients with chest trauma in a teaching hospital in Nigeria. Automobile accidents were the cause of the thoracic injuries in 73.1% of the patients; 71.7% of the patients were managed as in-patients. The management of the patients was essentially aimed at correction of hypovolaemia, tube drainage of pleural collections, and relief of pain by intercostal nerve block. Major operative procedures were adopted in 11 cases (7.6%) for persistent haemothorax or for pyothorax, ruptured diaphragm, ruptured abdominal viscus, and subdural haematona. No operative reduction of rib fractures was performed and only 1 of the 12 patients with flail chest was mechanically ventilated. The hospital mortality was 9.7% and, despite a high rate of default at follow-up attendances, no late death or serious complication was recorded. Th aspects peculiar to chest trauma in Nigeria are discussed.

Accidents, Traffic↗
PubMed1980

Traumatic aneurysms and arteriovenous fistulas in Nigeria.

Traumatic aneurysms and arteriovenous fistulas may be as common in the developing and less industrialized countries as they are in the developed countries. In a 4 year period 12 cases of traumatic aneurysms and arteriovenous fistulas were seen at the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Nine of these resulted from civilian injuries while 3 were due to military activities. The femoral vessels were involved in 7 cases while the extracranial carotid arteries were injured in 2 cases. Gunshots accounted for 6 lesions. Metal fragments and knife stabs were responsible for 2 cases respectively. All the 3 arteriovenous fistulas involved the femoral vessels--2 superficial and one deep. The vascular lesions were assessed by arteriography in 9 cases. All but one case were treated by excision, the vessels being reconstructed in 7 cases. There was one death due to septicemia.

Adult↗