[Effect of immobilized inhibitors of proteolysis on the course of experimental pancreatitis].
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Biomedical subjects
Publications and source records attributed to A S Synovets.
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Experiments were carried out in 195 albino rats. It was established that in acute peritonitis the rate of absorption of the colloid dye (tryptan blue) was sharply decreased. Kallikrein somewhat increased the absorption rate, especially at early terms while the inhibitor (kontrikal) was shown to substantially decrease it. The mode of injection (intravenous or intraperitoneal) failed to influence manifestations of the biological effect of the drug. The data obtained show that a disturbed absorption from the abdominal cavity may be corrected in acute peritonitis by injections of kallikrein.
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The protease activity of the wound walls and in the wound washings during the experimental skin and muscular wounds treatment with a Trieline-containing ointment, which is an inhibitor of the elastinase, and with some other proteolytic enzymes has been determined on white rats. It is suggested, that the application of such inhibitors suppresses the catabolism rocesses and stimulates the regenerative ones.
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