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A S Tikhonenko

Publications and source records attributed to A S Tikhonenko.

At least 55 records · Page 3Linked to original sources
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[Topology of the structural proteins of long tail fibers of phages T4D, DDVIh+ and DDVIh].

Topology of the products of the genes 34, 35, 36 and 37 of the bacteriophage T4D long tail fibers were determined with the aid of monospecific antibodies. The antibodies against gene product 34 were the only to interact with the proximal part of long tail fibers, but the distal part bound the antibodies against 35, 36 and 37. Product of the gene 35 is located at the joint-site with the distal part and binds the distance not more than 75 A long. Gene product 36 is located between these of 35 and 37 and occupy the region about 150 A. The capability of the antibodies obtained against the above-mentioned proteins were tested ot bind with long tail fibers diagnostic phages DDVIh+ and DDVIh Shigella disentheriae. We could'nt mark any difference in binding of the antibodies against gene 34, 35 and 36 product with DDVI phages and T4D. The distal part of the fibers of DDVIh bound the antibodies against product of gene 37 as T4D. Nevertheless DDVIh+ possesses only few antigenic sites relative to product of gene 37 of T4. The changes in the distal part of long tail fibers of h-strain DDVI may lead to the broadening of the host specifity of this virus.

Antibodies↗