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Biomedical subjects

A Sánchez Rodríguez

Publications and source records attributed to A Sánchez Rodríguez.

At least 19 recordsLinked to original sources
PubMed2000

[Sudden death as presentation form of papillary fibroelastoma of mitral valve].

We describe the case of a 35-year-old male, who presented with sudden death, secondary to anterior miocardial infarction due to embolism. Echocardiography, transthoracic and transesophageal, revealed a tumor in the anterior mitral leaflet. Tumor, histopathologically an papillary fibroelastoma, was excised and the mitral valve was replaced with a mechanical prosthetic valve. We revised the current literature on intracardiac papillary fibroelastoma.

Adult↗
PubMed1999

[Polymorphism of the IL1RN gene in Spanish patients with ulcerative colitis].

BACKGROUND: The etiology of the inflammatory bowel disease is unknown. Previous studies have shown an association between the allele 2 of IL1RN, the gene that encodes for the interleukin 1 receptor antagonist (IL-1ra), and the inflammatory bowel disease. PATIENTS AND METHODS: We have analyzed the incidence of the IL1RN alleles in 41 patients with ulcerative colitis and in 40 healthy subjects. RESULTS: Our results show the same allelic distribution between the subjects with ulcerative colitis and the healthy population. CONCLUSIONS: These results suggest that the allelic variants of the VNTR of the IL-1ra gene are not associated to a higher susceptibility to ulcerative colitis in Spanish population.

Adolescent↗
PubMed1999

[Non-Hodgkin's disease of the skull in a patient with AIDS].

The involvement of bone in non-Hodgkin's lymphoma (NHL) is rare and usually occurs in the late stages of the disease. The involvement of the cranial vault is exceptional and we have found only eleven cases previously reported in the revised literature, none of them in an AIDS patient. We report a case of a 38 years old man, intravenous drug abuser with AIDS diagnosed who presented with coma. Computed tomography scan showed a left frontal intra-parenchymatous haematoma and multiple osteolytic lesions in the whole of the cranial vault, that involved outertable, diploe and innertable. Intra-parenchymatous haematoma was removed and a biopsy of the osteolytic lesions was performed. Histology showed features of a large B-cell NHL. Patient died of infectious pulmonary complications. The incidence of NHL in patients with congenital or acquired immunodeficiencies is increasing and Epstein-Barr virus and other factors have been involved in its pathogenesis. That's the first AIDS patient reported to have a NHL involving the cranial vault. Tumour was limited to the cranial vault without involvement of soft-tissue. An intra-parenchymatous haematoma was associated without an explained cause.

Adult↗
PubMed1997

[Acute pancreatitis: clinical and therapeutic study with somatostatin].

A clinical and therapeutical study of 47 patients with the diagnosis of acute pancreatitis is reported. According to Ranson's criteria patients were initially classified as suffering from mild (28) and severe (18) acute pancreatitis. Twenty-eight, 11, 7 and 1 patients had biliary, alcoholic, idiopathic and neoplastic causes, respectively, of their conditions. The classification of episodes was made on the basis of clinical manifestations, biologic investigations, and imaging diagnosis, and is shown in the corresponding tables. The therapeutic profile was a randomized double-blind study: perfused somatostatin (SS) versus placebo (P) (physiologic saline 0.9%). The administration of somatostatin in perfusion (250 mcg/h/48 hours) did not improve significantly the parameters used to score the severity, although the mortality rate decreased significantly (p < 0.05) in the group of patients with the severe form of the disease.

Acute Disease↗
PubMed1997

[Brucellar meningitis as a peculiar form of clear fluid meningitis. Clinical study].

Out of 200 patients diagnosed of acute of chronic brucellosis, cases were first selected who had neurologic involvement (14%) and then those who had brucellar meningitis (CDC criteria) which corresponds to 4% of the total of the series. The clinical course, evolution time, neurologic manifestations and serologic and bacteriologic characteristics in blood and specifically in the cerebrospinal fluid (CSF). This study was contrasted with the literature review and the conclusion is reached that brucellar meningitis is a peculiar form of clear fluid meningitis, not exceptional in our environment considering the prevalence of brucellosis.

Adult↗
PubMed1997

[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus].

In the present investigation a study was made on the incidence of antiphospholipid syndrome (APS) on clinical and biological manifestations in a series or 32 patients (28 females and 4 males with a mean age of 25 years) diagnosed of SLE (ARA criteria) and APS (Harris criteria) compared with a group of 25 patients (19 females and 6 males with a mean age of 38 years) diagnosed of SLE without APS. This entails a selection from 124 patients diagnosed of SLE, and an incidence of 25.8% and 9.7% for ACA and LA, respectively. After a clinical protocol was filled, a complete immunological profile was obtained, with lymphocyte subsets, IL-2 receptor, coagulation study, isotype determination for anticardiolipin antibody (ACA), lupus anticoagulant (LA), serology for syphilis and imaging diagnostic techniques. Comparative results, with an statistic assessment, are shown in tables. It is concluded that SLE + APS population can be considered as definite for a peculiar SLE subtype.

Adult↗
PubMed1997

[Enterococcal infective endocarditis on native aortic valve].

Enterococcal endocarditis accounts for 10% of all bacterial endocardits. The infection progresses in a subacute way and when localized on the aortic valve it has a very poor prognosis since the valve is usually destroyed being death the fatal outcome. We report a case of a patient with infective endocarditis resulting from the implantion of the Enterococcus on the native aortic valve. Nor visk factors or an apparent main gate could be found. The patient was hospitalized after several months of a non especific febrile syndrome. The literature is reviewed. Diagnostic tests and clinical signs are discussed making emphasis on the refractoriness to chemotherapy.

Adult↗
PubMed1996

[Correlation among endoscopic, histological, and microbiological findings in gastroduodenal pathology associated with Helicobacter pylori].

We studied 152 patients referred for endoscopy of the upper gastrointestinal tract. Samples of the gastric mucosa and fundus were taken and processed for microbiological and histological study using conventional methods. Acute lesions to the gastrointestinal mucosa were those most frequently observed in endoscopy (28.3%). The overall prevalence of chronic gastritis was 90.8%. The prevalence of infection by H. pylori was 59.8%. All patients in which gastric ulcer or malignant lesions were observed had some kind of chronic gastritis. Duodenal ulcer was the lesion with the highest prevalence and statistical significance with respect to the existence of H. pylori infection. There was a highly significant correlation between H. pylori gastric colonization and lesions of the diffuse antral type and with gastric activity. The significant correlations among the endoscopic, microbiological and histological findings are discussed.

Acute Disease↗
PubMed1996

[Repeated strokes as a sign of multiple cerebral hydatid cysts].

A female patient with primary multiple cerebral hydatid cysts is described. Initial deterioration was followed several months later by reversible episodes of right hemiparesis, aphasia and sphincteral incontinence. This clinical picture has not been described in the literature and the etiopathogenic mechanism is uncertain.

Aged↗
PubMed1996

[Etiology of isolated general malaise].

Isolated general malaise (IGM) is defined as an imprecise sensation of feeling bad, without any other signs or symptoms that suggest even a diagnostic orientation. 137 patients who demanded medical help for IGM were selected and divided into three groups, according to their evolution: IGM of banal or benign cause; IGM of easy or attainable diagnosis; and IGM of difficult or prolonged diagnosis. The 37 patients of the latter group were integrated under the title of Unexplained General Malaise Syndrome (UGMS). The criteria of these syndromes are defined. The patients with UGMS were studied in order to make a diagnosis of its unknown disease, which was achieved in all cases except two. The non-specific symptoms that the patients with UGMS manifest and their relation to final diagnosis are described. When the final diagnosis was made, the number of diagnostic tests used, the time of hospitalisation and the derived economic cost was estimated in each case compared to the corresponding mean data, obtained. Depression as the most frequent aetiology detected in the patients with UGMS, should be the first consideration made in any evaluation.

Adult↗
PubMed1996

[Comparative study between seric I pepsinogen and seric gastrin, in the differentiation of the different types and localizations of chronic gastritis].

The present work analyzes the serie levels of pepsinogen I (PG I) and gastrin in relation to the histopathological findings with the optical microscope (OM) and electron microscope (EM) of different gastric mucosa biopsies obtained through fibrogastroscopy. 45 patients were studied (19 men and 26 women) with an average age of 63 with different clinical diagnoses documented later by fibrogastroscopy (peptic ulcer, neoplasia etc.), whose previous consent, two biopsies were taken at an antrum level and two biopsies at a fundic-body area level, analyzed later by OM and EM. The anatomopathological criteria followed in order to classify the condition of the mucosa was Whitehead's classification. The PG I and gastrin determination was carried out with RIA against a control group of 25 healthy individuals. Our study allows us to conclude that the normal or high serie concentration of PG I reflects a functional integrity of the fundic-body area, and low levels imply the presence of atrophic chronic gastritis at a fundic-body level. Thus a low level of PG I is a reliable marker of the atrophic condition of the mucosa and it can be considered as a precancerous factor.

Adult↗
PubMed1995

[Localized tracheobronchial amyloidosis. The usefulness of computed tomography].

Tracheobronchial amyloidosis is the most common form of localized bronchopulmonary amyloidoses, although its diagnosis is rare in daily practice. We describe two new cases of localized tracheobronchial amyloidosis, one in the form of a single node and one diffuse. We discuss in particular the contribution of computed axial tomography, mainly for diagnosing the diffuse form, in which a finding of a thickened tracheobronchial wall and intraluminal nodes should lead to the suspicion of this entity. The treatment of choice in most cases is resection with an Nd-YAG laser.

Amyloidosis↗
PubMed1993

[Detection and clinical course of metabolic multiple vascular risk syndrome].

The potential associations between the factors making up the vascular multi-risk metabolic syndrome (VMMS) or syndrome X (hypertension, diabetes, lipidic disorders, hyperinsulinemia and obesity) are studied: a) in patients with recent cerebral infarct or acute myocardial infarct; b) in patients hospitalized for the management of their hypertension, diabetes or obesity; c) at two years of evolution since the initial diagnosis of hypertension, diabetes or obesity. The results confirm that the VMMS, either complete or incomplete, is detected starting from the clinical management of any of its components (hypertension, diabetes, obesity) or complications (cerebral or myocardial infarct). These results and the ones regarding the evolution at two years of the risk factors associations, allows a discussion of the physiopathologic reality of the VMMS as an entity or a causal association.

Cerebral Infarction↗