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Biomedical subjects

A Sántha

Publications and source records attributed to A Sántha.

At least 19 recordsLinked to original sources
PubMed2000

Serum and cerebrospinal fluid cystatin C levels in vascular and Alzheimer's dementia.

INTRODUCTION: Cystatin C, a cysteine protease inhibitor, has been implicated in the neurodegenerative and repair processes of the nervous system, and the deposition of the same protein together with beta amyloid peptide was found as cerebral amyloid angiopathy (CAA) in different types of dementias. OBJECTIVE AND METHODS: Because of the differential diagnostic importance, serum and cerebrospinal fluid (CSF) cystatin C levels of 24 late onset Alzheimer's demented (AD) and 16 ischemic type of vascular demented (VD) probands were compared with 17 aged control (AC) persons. RESULTS: The serum and CSF cystatin levels were found in the normal range in all groups. The ischemic VD probands had the tendency to have higher cystatin C levels than the AD. No correlation has been found with the severity and duration of dementia and with the other measured parameters. CONCLUSION: These results indicate that lower than normal CSF cystatin C level is not a diagnostic marker in ischemic VD and CAA related to AD.

Aged↗
PubMed1994

[Endoscopic surgery in the management of carpal tunnel syndrome].

With the spreading of the "minimal invasive surgery" the interest was attracted in the last years in hand surgery too by the endoscopic technique. Authors describe the closed operative treatment according to Chow of the carpal tunnel syndrome. The instruments are presented and the single steps of the method was first used in detail. After exercises on cadavera the method was first used in clinical praxis by them in this country. On the basis of early experiences and the literature, the indication, the possible complications, the advantages and disadvantages of the method are analysed. According their opinion, with sufficient practice and the careful choice of indication, the endoscopic liberation of the carpal tunnel promises to be a remarkable therapeutic possibility.

Aged↗
PubMed1989

[Immunohistochemical and immunologic changes in aponeurosis in Dupuytren's disease].

Authors examined the aponeurosis of 23 patients with Dupuytren's contracture and of 5, formerly healthy persons, who died in consequence of accidents. It was found that the IgA and IgM content of the palmar aponeurosis is significantly elevated in Dupuytren's disease. The distribution of the immunglobulin containing cells and the fibronection localisation of the aponeurosis was also examined. On the basis of their examinations they think that the autoimmun mechanism may have a role in the development of Dupuytren's disease.

Dupuytren Contracture↗
PubMed1988

Immunopathological study on palmar aponeurosis in Dupuytren's disease.

The authors examined the immunological and immunohistochemical alterations of palmar aponeurosis in Dupuytren's contracture. In the IgG-content no difference were found between the intact and diseased aponeurosis. The mean of IgA content was 2 fold, the IgM content 3 fold higher in Dupuytren's aponeurosis than in normal ones. The immunoglobulin containing cells localised around the Dupuytren's nodules and in fibrotic, but not nodular parts of aponeurosis. Extracellular immunoglobulin deposits were not found.

Adult↗
PubMed1979

[Bridge transplantation in "no man's land"].

From 1968 to 1976, 89 flexor tendon injuries were reconstructed with bridging (mini-)-tendon grafts. This technique was also applied to injuries in "no-man's land". The results were better than with traditional tendon grafts. According to the criteria of BUCK-GRAMCKO there were very good and good results in 65% as compared to 51% with traditional tendon grafting. The method is recommended only for experienced hand surgeons.

Hand Injuries↗
PubMed1977

[Glomus tumor].

Explore the source record for details and available documents.

Adult↗
PubMed1976

Amperometric and polarographic study of the SH-activity of MEPRIN (alpha-mercapto-propionylglycine).

The SH-groups of alpha-mercapto-propionylglycine (MEPRIN) are remarkably stable in diluted solution either at room temperature or at 50 degrees C, even if storing takes place under air-bubbling. The SH-activity was measured by polarographic method and amperometric titration. Neutralization of the carboxyl group decreases the stability of the sulfhydryl groupings. Evaporation of neutralized solution leads to a 30--50 per cent decrease of SH-activity. Lyophilization reduces this loss by 10--15 per cent. Neutralization is best carried out in the absence of oxygen; in this case, 94 per cent of the sulfhydryl activity will persists, irrespective of the pH. The dissociation constant of MEPRIN-SH is pK' = 8.47. The SH-stability of the product is satisfactory when neutralized in nitrogen atmosphere to pH 3--5; a loss of only 5 per cent can be expected after storing in an oxygen-free 10(-3) molar solution for 144 hours. Between pH 6 and 8 this value is 31 per cent on the average, while at pH 9 it is more favorable again.

Amino Acids, Sulfur↗