PubMed Health⌕ Search

Biomedical subjects

A Saim

Publications and source records attributed to A Saim.

12 recordsLinked to original sources
PubMed1997

Prevalence of otitis media with effusion amongst pre-school children in Malaysia.

A cross-sectional screening test was done to determine the prevalence of otitis media with effusion amongst, preschool children in two district in Malaysia, namely Kuala Lumpur an urban district and Kuala Selangor a rural district. It involved 1097 preschool children aged between 5 and 6 years old. Presence of otitis media effusion (OME) is based on abnormal otoscopic finding, Type B tympanogram and absence of ipsilateral acoustical reflex. The overall prevalence rate of OME was 13.8%. The prevalence in Kuala Lumpur was 17.9%, while in Kuala Selangor it was 9.48%. Bottle feeding during infancy and high socioeconomic status of the parents was statistically associated with higher incidence of OME. Other factors such as race, premature delivery, passive smoking, allergy, asthma and family size, had no influence on the prevalence of otitis media with effusion.

Child, Preschool↗
PubMed1996

Differential effect of adrenocorticosteroids on 11 beta-hydroxysteroid dehydrogenase bioactivity at the anterior pituitary and hypothalamus in rats.

11 beta-Hydroxysteroid dehydrogenase (11 beta-OHSD) is a microsomal enzyme that catalyzes the dehydrogenation of cortisol (F) to cortisone (E) in man and corticosterone (B) to 11-dehydrocorticosterone (A) in rats. 11 beta-OHSD has been identified in a wide variety of tissues. The differential distribution of 11 beta-OHSD suggests that this enzyme has locally defined functions that vary from region to region. The aim of this study was to investigate the effects of the glucocorticoids B and dexamethasone (DM), the mineralocorticoid deoxycorticosterone (DOC), and the inhibitors of 11 beta-OHSD glycyrrhizic acid (Gl) and glycyrrhetinic acid (GE) on 11 beta-OHSD bioactivity at the hypothalamus (HT) and anterior pituitary (AP). Male Wistar rats were treated with GI or were adrenalectomized (ADX) and treated with either B, DM, or DOC for 7 days. All treatments were in vivo except GE, which was used in vitro. At the end of treatment, homogenates of HT and AP were assayed for 11 beta-OHSD bioactivity, expressed as the percentage conversion of B to A in the presence of NADP, 11 beta-OHSD bioactivity is significantly higher (P < 0.0001) in the AP compared with the HT. Adrenalectomy significantly increased the enzyme activity in the AP (P < 0.05), an effect reversed by B or DM. ADX rats treated with DOC showed decreased enzyme activity in the AP (P < 0.001) but increased the activity in the HT (P < 0.0001). Gl increased activity in both HT and AP, whereas GE decreased activity significantly. We conclude that the modulation of 11 beta-OHSD is both steroid specific and tissue specific.

11-beta-Hydroxysteroid Dehydrogenases↗
PubMedDate not supplied

Tuberculous thyroiditis cured by drug therapy.

A 73-year-old patient suffering from evolutive nodular goiter, free of other local complaints or changes in the general status is presented. A diagnosis of tuberculous thyroiditis with hypothyroidism is reached. This diagnosis is justified by the antecedents of the patient, positive IDR, low iodine uptake, characteristic scintigraphic and echographic picture of the thyroid. Following a treatment with tuberculostatics, potassium iodide and controlled life regimen for a year, thyroiditis was cured as proved by scintigraphic and echographic evidence, and normal iodine uptake and PBI.

Aged↗
PubMedDate not supplied

The female gonadic syndrome in bacillary endocrine diseases.

The paper reports on the endocrine-gynecologic syndrome of genital tuberculosis in the woman. The localization of the disease has a much higher incidence than it is currently believed by gynecologic and endocrinologic practitioners. The casuistry and pathogenic data exposed herein are aimed at reminding this situation. A selective list of references comes in support of authors' observations.

Adolescent↗
PubMedDate not supplied

The endocrine syndrome of occult tuberculosis.

Based on clinical observations made in the "C.I. Parhon" Institute of Endocrinology and in a clinic of catching diseases in Bucharest, the authors have isolated an endocrine syndrome of occult tuberculosis. The disease shows signs and symptoms of endocrine glands involvement. The paper presents the pathogenesis, epidemic spread and endocrino-tuberculostatic management.

Adult↗