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Biomedical subjects

A Sakula

Publications and source records attributed to A Sakula.

At least 19 recordsLinked to original sources

Vitamin A, zinc and lung cancer.

Serum vitamin A concentration were measured in 26 newly diagnosed lung-cancer patients and found to be significantly lower than those of patients of similar age with either non-malignant lung or non-lung diseases. The levels of vitamin A in the lung-cancer patients, but not in the controls, were significantly correlated with serum concentrations of retinol-binding protein (RBP) and zinc. It is suggested that low levels of zinc might reduce the synthesis of RBP and thus reduce the mobilization of vitamin A from the liver.

Aged

Primary malignant lymphoma of lung.

Primary malignant lymphoma of the lung is a rare variety of lymphosarcoma, to be distinguished from secondary lung involvement in disseminated malignant lymphoma. The condition tends to remain localized to the lung, and lymph nodes are not involved. The prognosis is better than in disseminated malignant lymphoma, and in the case described here a 35-year-old woman was treated by radiotherapy and chemotherapy and survived 20 years.

Adult

Pierre Adolphe Piorry (1794-1879): pioneer of percussion and pleximetry.

Piorry was born in Poitiers on 31 December 1794. As a medical student he served in the Napoleonic war in Spain. His teachers in medicine included Corvisart, Bayle, Broussais, and Magendie; he qualified in 1816 with an MD thesis: "On the danger of reading medical text books by the laity"! Laënnec's invention of the stethoscope (1816) and De l' Auscultation Médiate (1819) inspired Piorry to make an analogous contribution to the technique of percussion (which had been originally described by Auenbrugger in his Inventum Novum in 1761 and translated from the Latin into French by Corvisart in 1808). This led to Piorry's invention in 1826 of the pleximeter (le plessimétre) to help outline the internal organs (l'organographisme), which he described inDe la Percussion Médiate (1828). Piorry became renowned as a professor of medicine in many of the great Parisian hospitals (Charité, Pitié, and Hôtel Dieux). In 1832 he was appointed to L'Hospice de la Salpétrière, where he held a famous course of clinical lectures. He wrote prolificly on many aspects of medicine and published more than twenty books. He was, in addition, a poet of some distinction, and wrote a remarkable long poem Dieu, L'Ame et la Nature (1853). Piorry held his neologisms-for example, toxin, toxaemia, septicaemia, etc.-are still in use. This, together with the mixed reception that his advocacy of pleximetry received from his medical contemporaries, made him a controversial figure. He died on 29 May 1879.

Auscultation

Hodgkin's grave.

Explore the source record for details and available documents.

History, 19th Century

Accidental self-inoculation with killed Mycobacterium tuberculosis in Freund's complete adjuvant.

The case is described of a laboratory worker who was carrying out an animal immunological experiment and accidentally punctured the palm of his hand with Freund's complete adjuvant which contained heat-killed M. tuberculosis in a paraffin emulsion. A serious localised chronic tuberculoid granulomatous reaction developed which persisted for nine months. The significance of this phenomenon is discussed and the importance of the prevention of such an occurrence is emphasized.

Accidents, Occupational

Pulmonary metastases from basal-cell carcinoma of skin.

Although rodent ulcers are a relatively common malignant condition of the skin, pulmonary metastases arising from them are extremely rare. There have so far been only 29 authenticated reports of this condition. A further case is described of a man who, at the age of 35, developed a rodent ulcer (typical basal-cell carcinoma) on the forehead. Despite local excisions, skin grafting, and radiotherapy, the ulcer continued to recur, although there was no spread to regional lymph nodes. When he was aged 52, he developed widespread bilateral pulmonary lesions and a right pleural effusion. Thoracotomy provided a lung biopsy which showed the typical histological appearance of basal-cell carcinoma. He died aged 54, 19 years after the onset of the rodent ulcer, and necropsy confirmed that the pulmonary lesions were bloodborne metastases of basal-cell carcinoma.

Basal Cell Carcinoma

Bronchial asthma due to allergy to pancreatic extract: a hazard in the treatment of cystic fibrosis.

The mother of two children suffering from cystic fibrosis developed marked allergic symptoms affecting the eyes, nose and bronchi and severe bronchial asthma ensued. The cause of this allergy proved to be the powder released on opening the capsules of pancreatic extract which she provided for her children at each mealtime. The risk of pancreatic extract to those handling it, and possibly also to patients suffering from cystic fibrosis, is emphasized.

Adult