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Biomedical subjects

A Salvatoni

Publications and source records attributed to A Salvatoni.

31 records · Page 2Linked to original sources
PubMed1984

Growth hormone dependency of the effect of human serum on thymidine uptake by lectin-activated human lymphocytes.

This study of the effect of serum dialysis on thymidine incorporation into lectin-activated blood lymphocytes cultured in vitro showed that (1) after serum dialysis 3H-thymidine incorporation is very low or absent; (2) the addition of L-glutamine to dialyzed sera leads to recovery of 18% of 3H-thymidine uptake, and (3) addition of L-glutamine reduces the difference in the stimulating effects of acromegalic and hypopituitary sera observed before dialysis in a medium free of L-glutamine. Since the plasma level of glutamine is increased in acromegalics and reduced in hypopituitary patients, it is suggested that this amino acid acts as a growth hormone dependent factor or cofactor in the regulation of cell growth.

Acromegaly↗
PubMed1983

Effect of purified somatomedins on thymidine incorporation into lectin-activated human lymphocytes.

These data describe the effects of purified preparations of several growth factors on thymidine incorporation into phyto-haemagglutinin-activated (PHA) human lymphocytes. The somatomedins selected for this study included human somatomedins A and C, insulin-like growth factors (IFG1 and IGF2) and multiplication stimulating activity (MSA). Assays were carried out with and without serum. Complementary assays were performed with a low-molecular serum ultrafiltrate added to somatomedin C and to MSA. We found that all the peptides tested, except MSA, stimulated thymidine incorporation into PHA-activated lymphocytes in a dose-dependent manner, even though different doses were required to obtain a response. The data reported point out the multiplicity and the interrelationships of the serum factors involved in the stimulation of human cells growth.

Animals↗
PubMed1981

LHRH test in Bartter's syndrome before and during treatment with prostaglandin synthesis inhibitors.

LHRH tests were performed in two children with Bartter's syndrome before and during treatment with prostaglandin synthesis inhibitors. Before treatment, in patient 1 both basal and peak FSH and LH levels were elevated; in patient 2 basal and peak FSH levels were above the normal range, while basal and peak LH levels were normal. During treatment with an inhibitor of prostaglandin synthesis, abnormal values decreased into the normal range. These results support a possible role of endogenous prostaglandins in regulating gonadotrophin secretion in humans.

Aspirin↗
PubMedDate not supplied

Cyproterone acetate treatment in precocious puberty.

Seven girls with precocious puberty, idiopathic in 6 and associated with the McCune Albright syndrome in 1, were treated with 70 mg/M2/die of cyproterone acetate (CPA) for 11 to 36 months. Before and during treatment clinical parameters (weight, height, bone age, height velocity, prediction of adult height and pubertal development) were evaluated and plasma hormone assays in basal conditions (LH, FSH, 17 beta-estradiol, progesterone, testosterone, PRL, ACTH and cortisol) and after stimulation (LH, FSH, cortisol, GH) were carried out to assess the efficacy and eventual side effects of CPA. The regression observed in the clinical signs of puberty was considered satisfactory and the increase observed in the developmental quotient indicated an improved prognosis for adult height. No symptoms of adrenal insufficiency were observed but an adrenal suppressive effect of CPA was evident from the response to insulin hypoglycemia observed in 4 patients.

Child↗
PubMedDate not supplied

Molecular cytogenetics, RFLP analysis and clinical characterization of a de novo trisomy 10p case.

A new case of a de novo trisomy 10cen-->10pter is described. The karyotype was exactly defined by high resolution banding and FISH analysis; the chromosome aberration was of maternal meiotic origin as demonstrated by RFLP analysis. Clinical data are reported and correlated with other trisomy 10p cases from the literature. A critical review of the literature was made to define the phenotype of trisomy 10p syndrome.

Adolescent↗
PubMedDate not supplied

[Obesity and mental disorders in childhood].

The aim of the present study was to establish the prevalence and the type of psychiatric disturbances in a group of 42 obese children (18 boys aged from 6.8 to 13.8 years and 24 girls aged from 2.8 to 15.4 years; weight excess mean +/- 1SD 146.7 +/- 17.4%) and to evaluate the efficacy of a psychological approach of obesity in childhood. The children were in a normal caloric diet and they were encouraged to reach a "target weight" in a given period of time. 22 children were randomly assigned the "analyzed" group (auxological, alimentary and psychological evaluation) and 20 to the "control" group (auxological and alimentary assessment). The psychological evaluation was performed in 20 children (the parents of two children refused to give their consent) by the following tests: creative drawing test; draw a man test (Machover); draw a tree test (Koch); draw a family test (Co-man); Rorschach's test; TAT (Thematic Apperception Test) or, in the younger, the Düss's tales. The results of these psychological tests have been communicated to the patients and or parents. The children were followed for a period of 7 months. We found in 8 children (40%) personality disturbances (which were severe in two cases) and a psychological support was started. The observed main types of disturbances were depression and anxiety. Both were due to a missing harmony between their parents, to a difficult relationship either with their mother or with other children, and to the bad child's opinion of himself. In 4 subjects a psychological support associated with diet promoted a slow, progressive and continuous weight loss.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Nutrition in school-age children: a survey at a nursery school].

The results of a social-nutritional investigation in a maternal school are reported. Aim of the present study was to evaluate the dietary habits and life style in a group of 3-6 years old children and their compliance in following a diet in accordance with the LARN86 recommendations. The enquiry was carried out by a questionnaire, by an analysis of the ingesta and by a paediatric and auxological examination. Blood and instrumental tests (Lipids panel, Blood glucose, Insulin, Fructosamine, IgE, ECG) were performed in children with high familial risk of atherosclerosis. The main findings were the following: i. 17 children (21%) were classified as having high atherosclerosis familial risk; ii. the atherosclerosis high risk group showed also increased incidence (p less than 0.01) of familial allergy; iii. children had higher approval for food with high carbohydrate and animal protein content; iv. fat intake was proportional to the number of different types of fat bought by the families; v. excessive dietary lipids and low carbohydrate intake were found in most families. The revaluation at the end of the study showed a good compliance for the proposed diet scheme by children, but a poor compliance by their families.

Body Weight↗
PubMedDate not supplied

[Experience in diet therapy of child obesity].

During the last 14 years 1620 children and adolescents, 806 boys and 814 girls, aged 2-20 yrs, were referred for overweight as outpatients to the Pediatric Endocrine Center of the University of Pavia. On first admission 170 (10%) of the 1620 subjects had a percent overweight of less than 20% referred to ideal weight for height; 350 (22%) patients with overweight ranging from 25 to plus 100 were lost to follow up. We report our dietary management on 1100 children with percent overweight between 25-120, treated for a period of at least 3 months to a maximum of 7 years (mean 3 yrs). All patients were provided with a physiological diet with an adequate or slightly reduced caloric intake for their height (P 15%, F 25%, C 60%). A regular physical activity was recommended to our patients. Before they started the diet patients kept a daily food diary for three days, which included recording information about what food was eaten, how it was prepared and the time at which it was consumed. Food recalls showed a higher caloric intake for height and age with fat and protein excess, especially of animal origin. A lot of snacks, particularly sweets, and soft drinks were consumed during the day.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Intestinal invagination. Analysis of cases].

16 cases of intussusception, occurred in the last 9 years in the Pediatric Department of the Ospedale di Circolo of Varese, are reported. Barium enema was carried out in 15 cases and the reduction of the intussusception, attempted in 5 of them, was obtained in 3 (20%). The low rate of the attempts of reduction by barium enema is consistently related to a delay in the diagnosis; 56% of the patients showed actually at the diagnosis the three main symptoms simultaneously: abdominal pain, vomiting, "currant jelly stool". The significant positive correlation (p less than 0.01) between the symptoms duration at the diagnosis and the hospitalization period points out that a correct treatment of the intussusception depends mainly on a precocious diagnosis.

Barium Sulfate↗
PubMedDate not supplied

[Hyperthyroidism in children (author's transl)].

The present paper analyzes the causes, signs and symptoms of hyperthyroidism in children and the problems, complications and results associated with the various therapeutic regimes. Childhood hyperthyroidism is usually due to Grave's disease, an autoimmune thyroid disease. Genetic factors are also involved in its development. The diagnosis and in particular the differential diagnosis with Hashimoto's thyroiditis are discussed. Treatment of Graves' disease is controversial, but medical therapy is commonly accepted as the treatment of choice. Some dosage schedules of antithyroid drugs are considered, and some techniques for predicting remission status and relapse of disease are reported. Both the minor and more serious complications of medical therapy are examined. Careful follow-up for the development of hypothyroidism is advocated, especially in patients treated with radiation or surgery. Autonomous hyperfunctioning thyroid adenoma is rare, but occurs even in childhood, and can degenerate into carcinoma.

Adolescent↗