PubMed Health⌕ Search

Biomedical subjects

A Sampaolo

Publications and source records attributed to A Sampaolo.

13 recordsLinked to original sources
PubMed1999

Computer analysis of ultrasonic plaque echolucency in identifying high risk carotid bifurcation lesions.

OBJECTIVES: to confirm that plaque echogenicity evaluated by computer analysis, as suggested by preliminary studies, can identify plaques associated with a high incidence of strokes. MATERIALS AND METHODS: a series of 96 patients with carotid stenosis in the range of 50-99% were studied retrospectively (41 with TIAs and 55 asymptomatic). Carotid plaque echogenicity was evaluated using a computerised measurement of the median grey scale value (GSM). All patients had a CT brain scan to determine the presence of infarction in the carotid territory. RESULTS: the incidence of ipsilateral brain CT infarctions was 16% in the asymptomatic and 32% in the symptomatic plaques (p =0.076). It was 20% for <70% stenosis and 25% for >70% stenosis (p =0.52). It was 9% for plaques which had a GSM >50 and 40% in those with GSM <50 (p <0.001) with a relative risk of 4.6 (95% CI 1.8 to 11.6). CONCLUSIONS: the results confirm that computer analysis of plaque echogenicity is better than the degree of stenosis in identifying plaques associated with an increased incidence of CT brain-scan infarction and consequently useful for identifying individuals at high risk of stroke. What is required is a form of image standardisation in order to apply this method to natural history studies with stroke as the endpoint.

Carotid Artery, Internal↗
PubMed1996

Processed bovine pericardium as patch angioplasty for carotid endarterectomy: a preliminary report.

Although the routine use of a patch for closure of the arteriotomy after carotid endarterectomy is still debated, patch angioplasty is frequently used to avoid residual stenosis and to lower the incidence of later restenosis. Several materials are widely used for carotid patching, notably, autologous vein, Dacron and polytetrafluorethylene (PTFE). During recent years a heterologous stabilized graft made from bovine pericardium has been introduced. This paper reports the authors' experience of 52 carotid endarterectomies in which a patch of bovine pericardium was used to close the arteriotomy. The patients were followed with colour-duplex scanning over 12-30 months. This biograft did not require preclotting and proved to be easy to suture. Follow-up did not uncover any complications related to graft use. Although this is a preliminary report, it is concluded that bovine pericardium is a promising material for carotid patch angioplasty.

Animals↗
PubMed1996

Processed bovine pericardium as patch angioplasty for carotid endarterectomy: a preliminary report.

Although the routine use of a patch for closure of the arteriotomy after carotid endarterectomy is still debated, patch angioplasty is frequently used to avoid residual stenosis and to lower the incidence of later restenosis. Several materials are widely used for carotid patching, notably, autologous vein, Dacron and polytetrafluorethylene (PTFE). During recent years a heterologous stabilized graft made from bovine pericardium has been introduced. This paper reports the authors' experience of 52 carotid endarterectomies in which a patch of bovine pericardium was used to close the arteriotomy. The patients were followed with colour-duplex scanning over 12-30 months. This biograft did not require preclotting and proved to be easy to suture. Follow-up did not uncover any complications related to graft use. Although this is a preliminary report, it is concluded that bovine pericardium is a promising material for carotid patch angioplasty.

Animals↗
PubMed1989

Improvement of a practical method for priority selection and risk assessment among existing chemicals.

In a previous paper (A. Sampaolo and R. Binetti (1986). Regul. Toxicol. Pharmacol. 6, 129-154) an original pragmatic approach for priority setting and risk assessment among existing chemicals was presented. The experience subsequently acquired in the use of the method suggested some improvements, relevant for an easier application. The priority coefficient R has been redefined so that now it can range between zero (all data available) and 1 (no data available). In order to make the final figures more comparable with each other, the indexes are now expressed as percentage with reference to the maximum score obtainable if all parameters of the equation used had reached the maximum score. New general priority index and general risk index formulas, both for personal direct and environmental exposure, are also defined. Another modification concerns the application of the method to specific aspects, such as irreversible effects, immediate and delayed toxic effects, and so on. The method has then been validated on 80 known substances obtaining the respective ranking according to the specific kind of risk.

Animals↗
PubMed1989

[Herbicides in drinking water].

Toxicological implications due to the use of herbicide-contaminated drinking water, as well as other organic chemicals, are related to their nature and levels. These implications can be defined for each substance on the basis of an adequate evaluation of epidemiological information and experimental data on animals. In this paper, World Health Organization's procedures for establishing guidelines for 11 herbicides widely used in Italy are described. Furthermore, data and information about the use of these herbicides and their levels in Italian drinking-water supplies are also reported and discussed. Finally, factors and conditions responsible for the groundwater contamination by some herbicides in determined areas are presented and discussed.

Herbicides↗
PubMed1986

Elaboration of a practical method for priority selections and risk assessment among existing chemicals.

An original pragmatic approach is presented for priority setting among existing chemicals, as a result of a study requested by the European Community Commission. On the basis of a set of physicochemical, toxicological, and ecotoxicological properties considered as fundamental for a first evaluation of the substance, the proposed system develops a score for each property in both the presence and absence of the datum. The properties in this first set are considered additive. Other information on the substance (quantity on the market, plurality of possible exposures, bioconcentration, environmental diffusion, persistence and size of risk population) is included in a second set of multiplier parameters. Through this simple and self-improving system it is possible to work out, using different final formulas, different lists for different needs. Using 30 well-known substances as examples with which to check the system, it is possible to see how these substances distribute themselves as to priority for environmental or for direct personal exposure.

Environmental Exposure↗