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Biomedical subjects

A Saragea

Publications and source records attributed to A Saragea.

At least 19 recordsLinked to original sources
PubMed1987

Aging influence on the E-rosette forming cells, spontaneous cell mediated cytotoxicity, and antibody dependent cellular cytotoxicity in humans.

In 131 adults and 107 aging healthy subjects of both sexes, the percentage of the T lymphocytes in peripheral blood and the cytotoxic activities of NK and K cells, were determined. No age-related differences have been found in the number of peripheral blood lymphocytes, the binding of NK cells to the K562 targets, the percentage of E rosette forming cells and the ADCC level. An increased proportion of T suppressor lymphocytes in elderly subjects and a large inter- and intra-individual variation of NK cells activity in both adult and aged subjects were found.

Adult↗
PubMed1972

Diphtheria in Iran.

A study of diphtheria in Iran was undertaken during the summer of 1969. Diphtheria was found to be more common among the younger people and to reach its peak 3 months after the start of the school term, during the coldest period of the year. Owing to the liberal use of antibiotics a number of modified clinical cases were observed. Of the strains isolated, 89.7% were gravis, 1.3% intermedius and 9% mitis. Phage typing of these strains showed that the mitis and intermedius strains could only be typed by adapted phages and the majority of gravis strains were phage type XIV, which is the epidemic type seen in other countries.As the mass immunization campaign reduces the incidence of diphtheria in Iran, the epidemiological pattern of the disease will change as seen in the U.K. and U.S.A. It is, therefore, suggested that in the future further studies of diphtheria in Iran be undertaken in order to provide us with information about the changing epidemiological pattern of the disease.

Age Factors↗
PubMed1966

Phage typing of Corynebacterium diphtheriae. Incidence of C. diphtheriae phage types in different countries.

Simultaneously with the development of vaccines against diphtheria, the authors and their colleagues have studied the biological properties of the causative agent, Corynebacterium diphtheriae, and its role in the development of epidemics. This study has been made possible by the development of a lysotyping scheme for the bacterium, covering all three biotypes-gravis, intermedius and mitis. On the basis of this scheme it was possible to lysotype 73% of the 8694 strains of C. diphtheriae isolated in Romania between 1956 and 1966-99% of the gravis strains, 39% of the intermedius and 19% of the mitis; in all, 19 lysotypes were distinguished.To check the applicability of the lysotyping scheme on an international scale, 395 strains of C. diphtheriae were obtained from the reference laboratories in 14 countries in four continents. It was possible to lysotype 62% of the strains, including 93% of the gravis type. Details are given of the geographical distribution of the different lysotypes; two lysotypes not isolated in Romania were encountered among the foreign strains and will be incorporated into the scheme as the 20th and 21st lysotypes.There is a need to extend the number of intermedius- and mitis-type phages to enable more of these types of strain to be distinguished.

Bacteriophage Typing↗