PubMed Health⌕ Search

Biomedical subjects

A Saraswathy

Publications and source records attributed to A Saraswathy.

At least 19 recordsLinked to original sources
PubMed2003

In vitro snake venom detoxifying action of some marine algae of Gulf of Mannar, south-east coast of India.

The extract of the brown seaweed Padina boergesenii and the red seaweed Hypnea valentiae was found to detoxify (in vitro) the venom of Naja nigricollis. There was a remarkable reduction in the mortality of albino mice after intraperitoneal (i.p.) administration of reconstituted venom with the extract compared to those challenged with the venom only. The survival of the animals exposed to the venom incubated with the different concentrations of the extract was used as the in vitro detoxification parameter.

Animals↗
PubMed2002

Antimicrobial and phytochemical studies of Swertia corymbosa.

The aqueous, methanol, chloroform and hexane extracts of Swertia corymbosa were tested (in vitro) for their antimicrobial efficiency. Maximum inhibitory activity was noticed against Staphylococcus aureus and Salmonella typhi.

Anti-Bacterial Agents↗
PubMed2002

Phytochemical and antimicrobial studies of Begonia malabarica.

Phytochemical investigation of the various extracts of the leaves of Begonia malabarica Lam. (Begoniaceae) resulted in the isolation and identification of six known compounds, viz. friedelin, epi-friedelinol, beta-sitosterol, luteolin, quercetin and beta-sitosterol-3-beta-D-glucopyranoside. The aqueous and organic solvent extracts were also tested against ten human pathogenic bacteria and four fungal strains by the agar-well diffusion method. All the extracts were devoid of antifungal activity against the tested fungi. The hexane extract did not show any activity. The aqueous extracts showed activity against the Gram-negative bacteria except Vibrio parahaemolyticus. The chloroform and methanol extracts showed activity against all the tested bacteria. The study supported the claim of the usefulness of the plant in respiratory tract infections and also suggests its use in diarrhoea and skin diseases caused by pathogenic bacteria.

Anti-Bacterial Agents↗
PubMed2001

Phytochemical and antimicrobial studies on Drynaria quercifolia.

Friedelin, epifriedelinol, beta-amyrin, beta-sitosterol, beta-sitosterol 3-beta-D-glucopyranoside, and naringin were isolated from the dried rhizome of Drynaria quercifolia. The methanol extract showed broad and concentration-dependent antibacterial activity.

Anti-Bacterial Agents↗
PubMed1998

Mitochondrial myopathies--a clinicopathological study.

Mitochondrial myopathies are heterogeneous group of clinical disorders that can affect multiple systems besides skeletal muscles. The mitochondrial abnormalities in the skeletal muscles are morphologically identified by the presence of characteristic Ragged-red fibers (RRF) in the cryostat sections of the muscle stained with modified Gomori's trichrome stain. In this retrospective study, clinical and histopathological features in six patients with mitochondrial myopathies have been analysed. The utility of histochemical methods in confirming the diagnosis of mitochondrial myopathy has been emphasised.

Adolescent↗
PubMed1994

Mycotic aneurysms of the intracranial vessels.

The salient clinical and pathological features are reported of Aspergillus cerebral aneurysms in four young women who had undergone intra-abdominal surgery under spinal anaesthesia and developed clinical features of meningitis 7-16 days postoperatively. The circle of Willis showed ruptured aneurysm in the basilar artery and its branches. The role of iatrogenic factors in the pathogenesis of Aspergillus cerebral aneurysms is highlighted.

Abdomen↗
PubMed1994

Necrotizing myelopathy--a report of two cases with review of literature.

Necrotizing myelopathy is an uncommon neurological disorder. Till 1991, only 31 cases have been described in the literature. In this report, clinical and neuropathological features in two patients with necrotizing myelopathy are described. The precise aetiological agent in first patient was undetermined, However in the second patient there was serological evidence, suggestive of Herpes simplex virus infection.

Antibodies, Viral↗
PubMed1994

Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.

Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.

Animals↗
PubMed1994

Disseminated intra-cerebral microabscesses: a clinico-pathologic study.

In this retrospective study, clinical and neuropathological features were analysed in eight patients with disseminated intracerebral microabscesses. All the patients presented with clinical features, suggestive of an encephalopathic process of an acute onset. Neuroradiological and laboratory investigations were not helpful in establishing the diagnosis in any patient during their hospital stay. All the eight patients died in the hospital and at autopsy disseminated intracerebral microabscesses were the most striking feature. In two patients hyphae of Candida albicans were demonstrated within the microabscesses. Gram negative bacilli in two patients and gram positive and gram positive cocci in one patient were demonstrated in the microabscesses. Disseminated intra-cerebral microabscesses are usually an unrecognised manifestation of central nervous system infections and should be considered in the differential diagnosis of patients with encephalopathy of unknown aetiology.

Adult↗
PubMed1994

Nodular inflammatory mass of the dura mimicking a meningioma--a report of two cases.

Histopathological examination of surgical specimens in two patients with an operative diagnosis of meningioma, revealed the presence of dense nodular aggregation of lymphocytes, plasma cells and conspicious absence of meningothelial components. Possibilities of lymphoreticular malignancy, myeloproliferative disorders and other causes for various inflammatory diseases were excluded by appropriate investigation in these two patients. Pathogenesis of this localised lymphocyte-plasma cell aggreation in the dura manifesting as a space-occupying lesion could not be defined in these two patients. It is emphasised that this benign lesion should be recognised as well as distinguished from secondary lymphomatous deposits and solitary plasmacytoma of the dura.

Adult↗
PubMed1994

Intraventricular neurocytoma: a report of two cases.

Central neurocytomas are uncommon intracranial neoplasms. More than one hundred cases are documentated in the literature. In this report we describe the clinical and histopathological features in two patients with intraventricular neurocytoma. As the light microscopic features of neurocytoma resemble with that of an oligodendroglioma, it is essential to differentiate these two tumours, using either ultrastructural or immunohistochemical techniques.

Adult↗