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Biomedical subjects

A Sarno

Publications and source records attributed to A Sarno.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Red cell filterability and erythrocyte membrane microviscosity during ticlopidine treatment.

The effects of 10 days' treatment with 500 mg/day ticlopidine on the filterability of red blood cells in suspension and on the microviscosity of the red blood cell membrane was evaluated in 11 patients with vascular atherosclerosis. The results show ticlopidine to be effective in influencing the rheological measures of red cell filterability and membrane microviscosity: filterability was increased and microviscosity was decreased. Ticlopidine also decreased the extent of fluorescence polarization. These results are discussed regarding possible mechanisms of action of ticlopidine.

Arteriosclerosis↗
PubMedDate not supplied

[Current problems of the surgical treatment of rectal cancer: analysis of the literature and personal experience].

The surgical procedure is a crucial factor in preventing local recurrence in rectal cancer, and total mesorectal excision (TME) particularly is widely accepted as being associated with a decreased local recurrence rate. In this study, concerning 187 patients with rectal cancer, we compare conventional surgery, performed in 140 patients from 1979 to 1993, with a standardised TME procedure in 47 patients over the period from 1994 to 1998. The first group not treated by TME were operated on for 56 (40%) tumours of the upper rectum and 84 (60%) of the lower rectum; 35 (25%) were Dukes' A, 77 Dukes' B and 28 (20%) Dukes' C. 42 abdominoperineal amputations (30%) and 98 anterior resections (70%) were performed. The second group in which TME was performed comprised 17 (36%) tumours of the upper rectum and 30 (64%) of the lower rectum, 8 (17%) in stage I AJCC (Dukes' A), 16 (34%) in II (B) and 23 (49%) in III (C). 9 abdominoperineal amputations (19%) and 38 anterior resections (81%) were performed, 8 (21%) with an ultra-low anastomosis. In the first group of patients we observed 28 local recurrences (20%) and a 5-year disease-free survival in 50% of cases. In the second group we achieved a decreased rate of local recurrence (10.6%) which is about half that observed after conventional surgery, but there was no significant difference in survival. These data confirm the effectiveness of TME in reducing local recurrence rate, according to the literature; in future this procedure can get to reconsider the role of adjuvant therapy in the management of rectal cancer.

Adenocarcinoma↗
PubMedDate not supplied

Erythrocyte individual phospholipids and erythrocyte membrane fluidity in subjects with vascular atherosclerotic disease with and without diabetes mellitus of type 2.

In a group of 12 subjects (5 men, 7 women) with vascular atherosclerotic disease (VAD) and in a group of 17 subjects (9 men, 8 women) with VAD and with non-insulin dependent diabetes mellitus (NIDDM) we evaluated the red cell membrane individual phospholipids and their relationships with the erythrocyte membrane fluidity. Examining the group of non diabetic subjects with VAD, it is evident that no difference is present between normals and this group regarding individual phospholipids; in this group is present a slight correlation between the erythrocyte membrane fluidity (expressed as Iex/Im ratio) and phosphatidylethanolamine only. Examining the group of VAD subjects with NIDDM it is evident that between normals and this group a significant difference is present for phosphatidylcholine and phosphatidylserine; in this group no relationship is evident between red cell membrane individual phospholipids and Iex/Im ratio.

Aged↗
PubMedDate not supplied

Haemorheological evaluation with the Filtrometer MF4 in a group of diabetics.

In this research we evaluated the red blood cell deformability using the Filtrometer MF4. Our study includes a group of 44 diabetics and a group of 20 normal controls. Since we used only paper filters, the reading, made on four channels on the same sample, lasted 83' at the end of which we examined: SL80%, SL60%, SL50%, SL40%, SL20% (values of the trigonometric tangent of the alpha angle, i.e., the angle that the geometric tangent at the curve in predetermined points forms with the t axis); T50 (time employed to filter 50% of the sample); MinT (time employed to reach residual blood volume). Examining the trend of the SL values it is evident that the filtration curve is different between normals and diabetics and not between diabetics subdivided for vascular complications.

Adult↗
PubMedDate not supplied

[Hemorheological factors and metabolic parameters in a group of diabetic subjects].

Blood viscosity factors and some metabolic parameters were estimated in thirty-eight insulin-treated diabetics. The evaluation was carried out on admission and after eight weeks of controlled therapy. From this study it follows that blood viscosity factors do not permit us to distinguish, at these two stages, diabetics with complications from diabetics without while there is this possibility at the initial observation in diabetics subdivided for sex. Furthermore there are no significant variations, except for the haematocrit, of the average of blood viscosity factors and metabolic parameters at the initial and final observation. Very interesting is the negative relation between the Vrbc, parameter which studies the erythrocyte deformability, and the red cell 2,3-diphosphoglycerate (2,3-DPG) that seems more evident in diabetics with complications. Contrary to what has been reported in literature no relation between Vrbc and glycosylated haemoglobin (GHb) is present.

Adolescent↗