A Schellen | PubMed Health

PubMed2000

High throughput on-line solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum.

The feasibility of high throughput on-line solid phase extraction/tandem mass spectrometry (SPE/MS/MS) is tested for target analysis of paclitaxel in human serum. The use of a dual Prospekt system, with parallel SPE and elution directly to the mass spectrometer, resulted in a cycle time of 80 seconds for the entire, fully automated assay. The assay proved to be linear from 1 to 1000 ng/mL. Cartridges packed with small sorbent particles functioned both as SPE cartridges and as short analytical columns.

Blood Chemical Analysis↗

PubMedDate not supplied

Clinical report about some cases with retrograde ejaculation.

The incidence of retrograde ejaculation may be expected to increase by factors as a higher incidence of vascular- and colon-surgery, the increase of road accidents with as a result transversal lesions as well as the increased use of medicines particularly hypotensive drugs. After some remarks about the mechanism of ejaculation and the closing mechanism of the sphincter internus, some cases-histories are dealt with. After these case-histories, a survey is given about the etiology of the retrograde ejaculation. Finally some possibilities in treating this disorder are given, such as intravaginal deposit of urine after intercourse and the administration of a drug, called phenylpropanolamine, a so-called a-sympathicomimetic.

Ejaculation↗