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Biomedical subjects

A Scherpe

Publications and source records attributed to A Scherpe.

At least 19 recordsLinked to original sources
PubMed1986

[Effect of chemotherapy on the survival of patients with far-advanced squamous cell carcinoma of the head and neck. A comparative matched-pair analysis of conventional therapeutic procedures with and without chemotherapy].

Forty-four patients, surgically and/or radiologically treated after primary cytostatic treatment, were compared by matched-pair analysis with a historical control group of patients who had been conventionally treated by surgery and/or radiotherapy only. Both groups were largely identical with respect of tumour localisation and classification, regional metastases, and conventional treatment. The disease-free survival and overall survival times did not differ significantly between both groups. It appears that tumour remission following primary cytostatic therapy does not influence survival times. Primary cytostatic treatment offers advantages over conventional therapy only if it is combined with surgical and radiological procedures in selected patients.

Adult↗
PubMed1984

[Cytostatic therapy of advanced squamous cell carcinoma of the head and neck. A randomized study comparing cis-dichlorodiammineplatinum(II) and bleomycin with methotrexate and vindesine].

79 patients were randomized and treated either with cis-DDP 33 mg/kg i.v. day 1 and BLM 15 mg/m2 i.v. continuously day 2-6 (arm A) or less aggressively with MTX 30 mg/m2 i.v. day 1 + 6 and VDS 3 mg/m2 day 2 + 7 (arm B). Patients with inadequate response were further treated with the alternative regimen ("cross over"). Regarding response rates therapy A was superior to B (p = 0.01) respectively p = 0.05 for the cross over patients. Not pretreated in comparison to pretreated patients demonstrated not significantly better results. Pretreated patients had statistically superior response rates with arm A than with arm B (p = 0.05). All other prognostic factors were without any influence on treatment results. CR induced by chemotherapy (2 X) in not pretreated patients could be increased by additional surgery and X-ray therapy (CR = 26X). Survival times demonstrated no difference between both regimes. Chemotherapy was of less influence on median survival times after 39 months than in comparison to post-chemotherapeutically performed surgery +/- radiotherapy in 44 not pretreated patients. Chemotherapy: CR + PR to MR + NC + PD 16 respectively 13 months with 38 respectively 48% survivors (p = 0.25). Surgery +/- radiotherapy: CR + PR median not reached yet, MR + NC + PD 13 months with 60 respectively 18% survivors (p = 0.001).

Adult↗
PubMed1984

[Results of drug therapy with cisplatin and 5-fluorouracil in squamous cell carcinoma of the head and neck region].

30 patients with advanced squamous cell carcinoma of the head and neck received initial chemotherapy with Cisplatin (100 mg/m2 i.v. day 1) and 5-Fluorouracil (1000 mg/m2 as 24-hour-infusion day 2-6). 1 patient reached complete remission, 16 patients presented a partial remission, 11 patients showed little response and 2 patients had progressive disease. Following chemotherapy, 29 patients were referred to surgery and/or irradiation. 16 patients received radical surgery. The surgical specimen of 5 patients had no histological evidence of cancer. Objective and subjective side effects of chemotherapy were serious and some patients refused further treatment or were rejected. The results were compared with the data from the literature. The considerably better results from Decker and Weaver et al. were partially explained by an overestimation of remission quality by clinical evaluation and by more therapy courses. At this time, there is no evidence of any benefit from chemotherapy, because there is no data on relapse free survival and over all survival. The position of chemotherapy in the multimodality treatment programme of head and neck cancer still needs to be discussed further.

Adult↗
PubMed1984

[Indications for cytostatic therapy of recurrent cancer].

28 patients with recurrent squamous cell carcinoma of the Head and Neck underwent consecutive chemotherapy. Two different regimens were used: cis-platinum plus bleomycin and methotrexate plus vindesine. The former seemed to produce a better response to the latter, but neither differed in its influence on survival. Those patients in whom further radiation therapy or surgery was possible had the longest survival times. Two out of 28 patients who had surgery are still alive 36 months later. The indications for consecutive chemotherapy for recurrent squamous cell carcinoma ought to take into account the age and general condition of the patient, the extent of the recurrence and the possibility of further therapeutic measures.

Adult↗
PubMed1984

[Results of primary chemotherapy in 44 patients with advanced squamous cell carcinoma in the area of the head and neck].

44 patients with advanced squamous cell carcinoma of the head and neck were randomized and treated preoperatively either with arm "A": cis-DDP (3 mg/kg iv day 1) and BLM (15-20 mg iv continuously day 2-6) or arm "B": MTX (30 mg/m2 iv day 1 + 6) and VDS (3 mg/m2 iv day 2 + 7). Treatment with arm "A" was superior producing 73% complete and partial remissions (CR + PR) compared to 40% for arm "B" (p = 0,05). The number of patients with CR could be increased from 2 to 26 by surgery and/or radiotherapy. The median survival for patients with chemotherapeutically induced CR and PR was 16 months but this did not differ significantly from the median survival (13 months) of non responders (p = 0.25). For patients with CR and PR achieved by surgery and/or x-ray therapy the median survival point has not yet been reached, and this is significant compared to the non responders (p = 0.001). Five of 26 patients with CR died after 39 months of observation and 6 are living with recurrence. In addition to clinical trials, chemotherapy is indicated for patients with inoperable tumours. The value of chemotherapy can only be answered by randomized trials comparing chemotherapy combined with standard procedures against surgery and radiotherapy alone.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[2d interim evaluation of a chemotherapy study on patients with squamous cell carcinomas of the head-neck area. A comparison of 2 therapy regimens: cis-diamminedichloroplatinum (II) and bleomycin versus methotrexate and vindesine].

52 patients with epidermoid cancer of the head and neck region were either treated with cis-DDP and bleomycin (arm A) or with methotrexate and vindesine (arm B). In case of resistance patients were further treated with the alternative regimen (A leads to B or B leads to A). Treatment results are superior in arm A. Complete and partial remission were in A: 54%, in B: 31%, after crossover 46% and 0%, respectively. Status of pretreatment (operation and/or radiotherapy) is of minor importance for arm A than for the "soft" treatment of arm B. Preliminary analysis of survival and remission duration shows no significant difference in regard to A or B and status of pretreatment. However, those patients resistant to B and further treated with A have an increase of median survival from 3 to 9 months (p = 0.02). With primary chemotherapy inoperable tumors can be made operable with curative intention.

Adult↗
PubMed1981

[Chemotherapy of esophageal and cardial carcinomas].

In esophageal carcinoma chemotherapeutic agents such as bleomycin, methotrexate, cisplatin, VP-16, and vindesine produce remission rates up to 30%. Combination chemotherapy resulting in remission rates of about 50% has so far been insufficiently tested. Selection of patients with favorable prognostic criteria is mandatory for optimal treatment results. A combined modality approach is promising but needs further evaluation. The FAM regimen is recommended for the routine treatment of inoperable stomach carcinoma. The specific problems of upper gastrointestinal tract cancer chemotherapy are discussed.

Antineoplastic Agents↗
PubMed1975

Myocardial mechanics and oxygen consumption in experimental hyperthyroidism.

Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats (N = 15), pretreated with cristaline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination. Isotonic afterload and isometric contractions were employed. Oxygen consumption was determined polarographically. Data obtained were compared with control studies on papillary muscles taken from euthyroid cats (N = 15). In isotonic afterloaded contractions the extent of shortening was nearly identical in both groups. However, maximal rate of isometric tension development and velocity of isotonic shortening were considerably increased in hyperthyroid myocardium (by 48 and 42%, respectively). Myocardial oxygen consumption was significantly increased in hyperthyroidism (by 47%), primarily because of an increased maximal rate of isometric tension development and-to a small extent-increased isotonic contraction velocity.

Animals↗