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Biomedical subjects

A Schlegel

Publications and source records attributed to A Schlegel.

13 recordsLinked to original sources
PubMed1991

Semliki Forest virus envelope proteins function as proton channels.

It has been shown that isolated nucleocapsids of Semliki Forest virus (SFV) contract upon low pH exposure (Soederlund et al., 1972). This contraction of the nucleocapsids has been used as an indicator to demonstrate that the spike proteins of SFV can translocate protons into the interior of the virus particle upon low pH (5.8) exposure. Spikeless virus particles obtained after bromelain digestion, which were used as a control, did not translocate protons. This implies that the ectodomain of the spike plays a crucial role for the proton translocation.

Aedes↗
PubMed1991

[In-vitro research on the precision of the marginal adaptation of computer-milled titanium crowns (I). Scanning electron microscopy marginal fissure analysis].

The Digitising Computer System (DCS) can be mechanically programmed to produce computer-milled titanium frameworks for veneered ceramic single crowns using three-dimensional computer models. Titanium frameworks were constructed in this way during the present in-vitro investigation involving twelve extracted teeth with shoulder or chamfered preparation. An electron scanning microscope was used to evaluate the marginal accuracy of fit of the cemented crowns. The total length of 42.7 cm comprised by the crowns enabled 397 measuring points to be used. The arithmetical mean marginal leakage for the shoulder preparation amounted to 68.3 +/- 61.1 micrometers, and 95.7 +/- 83.2 micrometers for the chamfered one. From these results, it can be affirmed that the marginal accuracy of fit in constructing crowns by the Digitising Computer System is comparable to that of the conventional method.

Computer Graphics↗
PubMed1991

[The in-vitro study of the marginal fit accuracy of computer-milled titanium crowns. II. A histological-morphometric marginal-gap analysis].

The Digitising Computer System (DCS) can be mechanically programmed to produce computer-milled titanium dentures for veneered ceramic single crowns using three-dimensional computer models. A first analysis by electron scanning microscope of the marginal leakage in titanium framework on 12 extracted teeth showed a marginal accuracy of fit of 68.3 +/- 61.1 microns for the shoulder, and 95.7 +/- 83.2 microns for the chamfered preparation. Owing to limited indicative value of recordings by electron scanning microscopes, the crown edges of the 9 teeth with shoulder preparations were subjected to histological-morphometric measurements. Using this more accurate investigational system, a distinctly higher arithmetic mean of 89.2 +/- 69.1 microns for the marginal accuracy of fit was achieved. It also enabled the marginal leakage of cement (96.5 +/- 85.1 microns), the marginal adaptation (37.4 +/- 93.3 microns) and the shoulder formation (44.4 +/- 58.9 microns) to be judged.

Computer Simulation↗
PubMed1987

Inter-episode major and subclinical symptoms in affective disorder.

A prospective 1-year study was conducted in 69 patients with affective disorder. Despite remission, there was a significant continued presence at each visit of major symptoms of mania and depression and of mean mood shift. Furthermore, sub-clinical affective symptoms, as determined by General Behavior Inventory self-rating scores completed at 4 month intervals, continued at a level throughout the entire year significantly higher in patients than in 14 normal controls. Finally, as expected, presence of subclinical symptoms on the GBI correlated significantly with presence of major symptoms and mood shift. Correlation varied from 0.55 to 0.61; all significances were less than 0.001.

Adult↗
PubMed1987

Lithium level and inter-episode symptoms in affective disorder.

Forty-two patients with a history of affective disorder on lithium prophylaxis alone participated in a prospective 1-year study of inter-episode symptoms. Despite expected significant differences in mean plasma lithium level in patients, those with mean levels above the median (0.82 +/- 0.10 mEq/l) did not differ in incidence of major symptoms per visit, in mood shift per visit, or in rate of subclinical symptoms on the General Behavior Inventory from those patients with mean level below the median (0.52 +/- 0.09 mEq/l).

Affective Disorders, Psychotic↗
PubMed1986

Fluoxetine response: endpoint vs pattern analysis.

A 6-week double-blind trial of fluoxetine treatment of unipolar major depressive disorder in 49 patients was evaluated in terms of improvement in the Hamilton Depression Rating Scale (HDRS) and Clinical Global Improvement (CGI) scores. A relationship was found between change in HDRS (absolute and percentage decrease from baseline) and final CGI ratings. However, because of a few placebo-responders, endpoint analysis with both the HDRS and CGI showed no differences between active drug and placebo. Pattern analysis of persistent response did successively separate active drug from placebo (less than 0.05).

Adolescent↗
PubMed1986

Prediction of lithium dose: a mathematical alternative to the test-dose method.

A method of estimating the optimal dose of lithium is presented. The charts of 548 patients were reviewed to obtain data regarding the factors thought to affect the lithium dose, and an equation to estimate the dose was derived by stepwise multiple linear regression. The equation was also applied to 390 patients to determine the difference between the estimated and the actual dose; the mean difference was only 19 mg/day and the standard deviation was 325 mg/day. Lithium level, presence of a cyclic antidepressant, age, sex, and weight were found to be important variables for estimation of lithium dose.

Adolescent↗
PubMed1986

Pattern analysis of antidepressant response to fluoxetine.

Seventy patients with unipolar major depressive disorder were treated with fluoxetine or placebo in a 6-week double-blind trial and were evaluated by changes in scores on the Hamilton Rating Scale for Depression (HAM-D) and the global improvement measure of the Clinical Global Impressions (CGI) scale. High correlations were found between the changes in HAM-D scores from baseline to endpoint and the final CGI improvement ratings. In patients with moderate depression (baseline HAM-D score of 20 or more), the differences in endpoint analysis between active treatment and placebo groups were significant. A persistent pattern of improvement was noted in 27% of those receiving fluoxetine but in none of those receiving placebo. Physician and patient evaluations as determined by the improvement measure of the CGI were closely correlated.

Adolescent↗