Alterations in the circulatory system of anaesthesized dogs following administration of histamine and histamine H1- and H2-Receptor antagonists in relation to plasma histamine levels.
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Biomedical subjects
Publications and source records attributed to A Schmal.
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In dogs histamine was predominantly released from liver and antrum by intravenous injection of trypsin. The histamine content of the human liver was found to be high enough to allow the invasion of mg amounts of histamine into the circulation after histamine release. In blood histamine was rapidly taken up by corpuscular elements. At present it cannot be decided whether this mechanism leads to detoxification or to a more powerful action of histamine in the microcirculation.
In contrast to the effects of rapid infusion of gelatin and dextran preparations, no histamine release was observed in 10 human subjects (volunteers) following rapid infusion of hydroxyethyl starch. This was measured by fluorometric histamine determination in venous plasma. Furthermore no clinical symptoms of an allergic or anaphylactoid reaction could be detected in any of the volunteers.
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