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Biomedical subjects

A Schramm

Publications and source records attributed to A Schramm.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Terbutaline-induced metabolic responses after propranolol and metoprolol].

Subcutaneously administered terbutaline (7 micrograms/kg Bricanyl) induced typical changes in carbohydrate and fat metabolism and cardiovascular effects in ten healthy volunteers. A significant inhibition of changes in systolic and diastolic blood pressure, heart rate and plasma glycerol, FFA, lactate and potassium levels was seen after pretreatment with 0.1 mg/kg propranolol (Dociton) or 0.2 mg/kg metoprolol (Beloc). Intravenous metoprolol showed weaker beta-blocking activity than propranolol, but proved to be more effective in its action on systolic blood pressure.

Adult↗
PubMed1982

Methodologically critical interactions of circadian rhythm, sex, and aging characterize serum aldosterone and the female adrenopause.

Nine 20- to 26-year-old and ten 70- to 78-year-old diurnally active, nocturnally resting women in Würzburg, Federal Republic of Germany, gave blood at 0700, 1000, 1300, 1600, 1900, and 2200 for radioimmunoassay of aldosterone. Single and population-mean cosinors were applied. A multivariate analysis of circadian rhythm characteristics revealed effects of age on the amplitude (p = .003) but not the mesor of aldosterone in women (i.e., the age effect could only be detected at certain circadian times but not at others). No change with age was found for concomitantly sampled men. Statistically significant interactions among circadian time, age, and sex (p = .001) establish the adrenocorticopause in women and suggest that it may occur earlier in women than in men, in keeping with similar results on serum cortisol in the same subjects. This phenomenon awaits scrutiny from the viewpoint of its bearing on longevity and life quality. These results also indicate the importance of assessing chronobiological characteristics.

Adult↗
PubMed1981

[Hormonal adaptive capacity in old age. Behavior of hormonal parameters after insulin hypoglycemia in young and old patients].

The insulin-hypoglycemia-test seems to be an appropriate instrument for the examination of the hormonal ability to adapt, even at old age, whereby especially accurate control is necessary. Although older patients of our policlinic show lower basic cortisol- and HGH-values, the increase of catecholamines, cortisol and HGH is not diminished, thus demonstrating a satisfying stress-adaptability. We relate the fact, that in literature the basic cortisol- and HGH-levels are also found to be mostly normal, to the different criteria in the selection of patients.

Adult↗
PubMed1981

[Normal range and significance of serum ferritin; variations with age and sex (author's transl)].

Iron is necessary for every of organic life. The depot forms of the iron are Haemosiderin and Ferritin. Comparisons of the serum ferritin with the body iron contents measured through quantitative phlebotomy, intestinal iron absorption and bone marrow puncture showed extremely significant correlations. Since there are often lower serum iron levels to be found in elderly persons and the hypoferric anemia is the most important cause of it, the question of the valency for the serum ferritin analysis arises. Two groups of young and old persons were examined. Their age ranged between 20 and 30 as well as 60 and 90 years. It showed an increase of the serum ferritin level depending on the age. There are also sexual distinctions. The added immunoglobulin determination in older patients does not lead to a better interpretation of the investigated serum ferritin value. The analysis of the serum ferritin is of great importance in young patients as well as for some illnesses, but becomes problematic in old patients because of the increasing number of disturbing factors.

Adolescent↗
PubMed1981

[Type and frequency of cardiac arrhythmias dependent on age, therapeutic aspects (author's transl)].

Resting-, exercise and 24-h-ECG tracings of outpatients were examined for cardiac arrhythmias and were analyzed for age-dependent phenomena in the range between 20 and 100 years. Typical of higher age was especially the combination of different arrhythmias, in particular the simultaneous occurrence of slow and fast disturbances, which, of course, makes medical therapy difficult. Since ventricular arrhythmias, when classified according to Lown, have a better prognosis in the age group above 70 than between 40 and 70 years, antiarrhythmic drugs should be prescribed with extreme caution to older people and should be limited to exceptions which are detailed in this study.

Adult↗
PubMed1980

[Heart and circulation in very old age (author's transl)].

With increasing age a number of well established patho-anatomical changes take place in heart and blood vessels. We compared data from 90--100 year olds taken from the literature with results of our own investigations in 500 centenarians. Cardiac performance deteriorates in this age group but anginal attacks diminish. ECG and long term ECG investigations reveal a multitude of extrasystoles and of disturbances in impulse formation and propagation, which depend on the patient's vitality; this is also true for cardiac size. Coronary infarcts are rarely found in patients' history or ECG. Systolic blood pressure (taken from 118 centenarians) was at the upper limit of normal, diastolic BP was in the middle of the normal range (145/78 mm Hg). Cardiac polypathy (i.e., several abnormalities occurring in the same heart) demonstrated post mortem in one patient (probably the oldest patient so examined) is a small scale repetition of the polypathy of the whole organism. The increase in the number of physiological and pathological findings in single organs is a true aging process.

Age Factors↗
PubMed1979

[Progressive systemic sclerosis - long-term treatment with azathioprin (author's transl)].

The study presents the results of an Azathioprin long-term therapy in 19 of 60 patients with progressive systemic sclerosis (PSS). Average treatment was 47 months (6 to 114 months). The patients received 2-2,5 Azathioprin/kg bodyweight daily. In 16 cases no further progression of PSS was noted. One patient showed minor deterioration. In particular no further deterioration in the lung and kidney manifestations were found. Two patients died. A female patient showed signs of osteomyelofibrosis after being treated for 70 months. She died 3,5 years after Azathioprin had been discontinued. The second patient died of right heart failure after recurrent pulmonary emboli. On the whole treatment with Azathioprin over a long period of time seems in most cases to hold the progression of the disease. The unfavourable prognosis can therefore be much improved.

Adolescent↗
PubMed1975

[Mitochondrial antibodies induced by drug administration in patients with and without pseudo LE syndrome (author's transl)].

The pseudo LE syndrome was first described in 1972. It is a severe, sometimes fatal condition, in which high titres of mitochondrial antibodies are a constant feature. In the vast majority of cases detected, Venopyronum in dragée form (containing phenopyrazone, horse-chestnut extract, and cardiac glycosides from various plants), had been taken prior to onset of the clinical symptoms. It is probably commoner, that following intake of the drug mitochondrial antibodies appear without clinical manifestations. In both situations, disposition, dose and duration of treatment are important factors. There is reasonable ground to believe that not just a single component, but rather the combination of various substances in the preparation is responsible for the induction of an autoimmune process. At the present time it appears that an idiopathic form, without drug contact, also exists.

Adult↗