PubMed Health⌕ Search

Biomedical subjects

A Sebille

Publications and source records attributed to A Sebille.

52 records · Page 3Linked to original sources
PubMed1980

The Hoffmann reflex of the soleus muscle. A study in leprosy.

The H reflex of the soleus muscle was used to investigate the monosynaptic reflex arc of two groups of leprosy patients compared with a similar group of normal subjects. The H reflex recordings show two abnormalities: (1) An increase in the latency of the reflex without difference between lepromatous and borderline patients. (2) A decrease of the Hmax:Mmax amplitude ratio more pronounced in the lepromatous group. The discrepancy between these results and the commonly described preservation of the deep tendon reflexes in leprosy is discussed and the hypothesis that leprosy neuropathy would affect all nerve trunks related to blood vessel changes in suggested.

Adolescent↗
PubMed1980

Electrophysiological evidence for motor unit impairment during the treatment of leprosy.

Although neuropathy is the most striking feature in leprosy, the effects of various drugs are usually assessed by dermatological and bacteriological improvement. This short term electrophysiological study shows that both antileprosy drugs, DDS and Sulforthomidine, do not affect the insidious deterioration of motor unit condition in lepromatous and borderline BT patients. Differences observed in the results of the two groups were discussed.

Dapsone↗
PubMed1979

Electromyographic recording and muscle biopsy in lepromatous leprosy.

The aim of this study was to detect early muscular changes in lepromatous leprosy using simultaneously electromyography and muscle biopsy. In 13 subjects a single clinically normal muscle innervated by the popliteal nerve was studied. Three were found to be normal. All the others were electromyographically denervated. Histopathologic findings included only 3 cases of fascicular atrophy. In 8 cases inflammatory nodules were observed in the connective tissue of the muscle and acid-fast bacilli were present in Virchow cells in 5. In only one patient were intact acid-fast bacilli found in muscle cells. It was concluded that electromyography was the better method of detecting early denervation, while muscle biopsy was the better examination to detect "lepromatous myositis". In practice these techniques are complementary in the study of muscle data in lepromatous leprosy.

Adolescent↗
PubMed1978

[Electrophysiological study of latent neuropathies induced by perhexiline].

The aim of this study was to estimate the frequency of latent perhexiline-induced neuropathy in man. Several electrophysiological parameters were recorded and compared between a control group and a group of treated patients, without clinical evidence of neuropathy. The Hmax/Mmax amplitude ratio of the soleus H reflex was decreased in 2/3 of the patients. The H reflex latency was increased in 1/3 of them. The distal motor latencies of ulnar and popliteal nerves were increased in 1/4 of them. Only 1/3 of the patients treated did not show any electrophysiological abnormality. The validity of these results and the possible mechanisms involved are discussed.

Adult↗
PubMed1978

Respective importance of different nerve conduction velocities in leprosy.

Motor and sensory nerve conduction studies were performed in the distal part of the ulnar, median and radial nerves of 12 tuberculoid and 12 lepromatous leprosy patients, compared with 15 normal subjects. Slowing of sensory conduction velocity (SCV) was shown in all nerves with no difference between tuberculoid and lepromatous patients. The radial SCV slowing is correlated (P less than 0.001) with the clinical findings. Impairment of motor distal latencies was observed only in tuberculpoid patients. It is concluded that the radial SCV is the most reliable conduction test and is proposed as an early diagnostic test for leprosy.

Adolescent↗
PubMed1978

[Effects of percutaneous heterosegmental electric stimulation (electro-acupuncture) on the nociceptive flexion reflex in man].

A comparative study of the effects of electro-acupuncture of the HO KU point and of a placebo control point were carried out in man, taking as an objective test of pain the threshold of a pain induced flexion reflex. In the absence of electrical stimulation of the HO KU point, or of the control point, no variation in the painful reflex threshold was seen. This remained stable throughout the experimental session. However, electrical stimulation of the HO KU point resulted in a 115 p. 100 increase in the reflex threshold, whilst that of the control point resulted in an increase of 20 p. 100 in the threshold of the same reflex. These results are discussed on the basis of data in the literature.

Acupuncture Therapy↗
PubMed1978

[Recent results concerning muscular disorders arising from thyroid gland dysfunction (author's transl)].

The hight number of muscular disorders which may be observed clinically in thyroid dysfunction contrast with the paucity of knowledge concerning the mechanisms of action of the thyroid hormones. Those which have been described allowed the following conclusions to be made : 1) The thyroid hormones simultaneously increase the oxydative phosphorylation in mitochondria and the activation of glycogen phosphorylase. 2) They modify the properties of cell membrane without noticialy changing the cytoplasm (light and electron microscopically). These modifications are concommitant with a reduction in resting membrane potential associated with anomalies of Na+ conductance and Ca+ uptake. 3) The appareance and the number of motor units in each muscle is dependant on the hormonal impregnation. However, these diverses actions do not reveal whether the thyroid hormone receptors are in the muscle or if they act via the intermediary of a neuronal trophic factor.

Animals↗
PubMed1977

[Radial nerve potential at the wrist of man].

Radial nerve potential was studied at the level of the wrist in 13 normal subjects. Simultaneous recording at the level of the median nerve potentials and of a block of its conduction showed that median activity spreads to the area of recording of radial potentials. However, the radial latency is shorter so that potentials of each nerve can be distinguished. This technique could be applied in current practice.

Adult↗
PubMedDate not supplied

Further aspects of muscular dystrophy in mdx mice.

The histopathological aspects of leg muscles in young, adult and old mdx mice were compared. Before 1 yr of age, the mutant showed a vigorous regeneration, following the fibre necrosis, which led to hypertrophic muscles. Hypertrophy resulted from a mixture of hypertrophic and small fibres but not from fibrosis. From the age of 15 months, the muscles progressively atrophied and the fibres were atrophic or split. An important degree of fibrosis occurred particularly in soleus and plantaris muscles. These aspects in old mdx mice are similar to those described in other dystrophinopathies in animals and humans.

Aging↗
PubMedDate not supplied

[Recent results concerning muscular disorders arising from thyroid gland dysfunction (author's transl)].

The right number of muscular disorders which may be observed clinically in thyroid dysfunction contrast with the paucity of knowledge concerning the mechanisms of action of the thyroid hormones. Those which have been described allowed the following conclusions to be made: 1) The thyroid hormones simultaneously increase the oxydative phosphorylation in mitochondria and the activation of glycogen phosphorylase. 2) They modify the properties of cell membrane without noticiably changing the cytoplasm (light and electron microscopically). These modifications are concommitant with a reduction in resting membrane potential associated with anomalies of Na+ conductance and Ca+ uptake. 3) The appearance and the number of motor units in each muscle is dependant on the hormonal impregnation. However, these diverses actions do not reveal wether the thyroid hormone receptors are in the muscle or if they act via the intermediary of a neuronal trophic factor.

Animals↗
PubMedDate not supplied

[Frequency of the association of perforating plantar leprotic lesions and truncal involvement of the posterior tibial nerve].

This study was performed to determine the electrophysiological status of the posterior tibial nerve and its muscular innervation in patients both with and without plantar ulcers without osteitis. In both cases, motor distal latencies remained normal, but the denervation of the plantar muscles was significantly more important in patients with ulcers. These results show that axonal degeneration is predominant in leprous neuritis affecting the tibial nerves. Neurolysis was performed in twelve patients in the retromalleolar part of the tibial nerve. All patients have recover from their ulcers, but no improvement of their electrophysiological parameters was observed.

Foot↗