A Seelhorst | PubMed Health

PubMed1990

[Eye involvement in hyperimmunoglobulin E syndrome].

The Hyperimmunoglobulinemia-E-Syndrome (HIE) is characterized by high levels of serum-IgE, diminished counts of T-suppressor-cells, eosinophilia, and disturbed chemotactic functions of neutrophil granulocytes. An 8 years old female, suffering from hyperimmunoglobulinemia E (HIE), showed marginal corneal ulcera since five years. Positive conjunctival smears included several bacterias and chlamydia, but never local herpes virus. Inspite of treatment by antibiotics, virostatica, and therapeutical contact lens, a spontaneous corneal perforation occurred. A penetrating keratoplasty was successful for a short time, but soon ulceration rose again. At last a second penetrating keratoplasty was necessary. The early status showed tidy results, but some weeks later marginal ulceration occurred again. There was no clinical proof for herpetical genesis of the course, but evidence is conceivable for pathomechanisms similar to conjunctivitis vernalis.

Child↗

PubMed1986

Prejunctional opioid receptors in the pulmonary artery of the rabbit.

The possible existence of prejunctional opioid receptors at postganglionic sympathetic vasoconstrictor axons was studied in superfused spiral strips of the main pulmonary artery of the rabbit. Ethylketocyclazocine 0.1 and 1 mumol/l and dynorphin-(1-13) 0.1 mumol/l but not morphine 0.01-1 mumol/l, (D-Ala2, NMePhe4, Gly-ol5)-enkephalin 0.001-1 mumol/l, Leu5-enkephalin 0.1-5 mumol/l and (D-Pen2, L-Pen5)-enkephalin 0.01-1 mumol/l reduced contractions of the artery strips elicited by electrical field stimulation at 0.5 or 1 Hz. The effect of ethylketocyclazocine was antagonized by naloxone. Ethylketocyclazocine 1 mumol/l did not change contractions elicited by exogenous noradrenaline (5-10 nmol/l). In artery strips preincubated with 3H-noradrenaline, ethylketocyclazocine 1 mumol/l diminished both the overflow of tritium and the contraction evoked by field stimulation at 1 Hz. All inhibitory effects were small, amounting maximally to about 20%. The results indicate that the postganglionic sympathetic axons of the artery possess prejunctional opioid receptors, activation of which leads to inhibition of the release of noradrenaline and, in consequence, inhibition of neurogenic vasoconstriction. It seems likely that the receptors are, at least predominantly, of the kappa-type.

Animals↗