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Biomedical subjects

A Sekiguchi

Publications and source records attributed to A Sekiguchi.

45 records · Page 3Linked to original sources

[Cardiac operation in children of Jehovah's Witnesses].

The perioperative courses of 5 open heart operations in children of Jehovah's Witnesses are reviewed. The age of patients ranged from 6 to 13 years old and the body weight, from 21.5 kg to 38.5 kg. All the patients survived and are doing well now. The cardiopulmonary bypasses, primed with lactated Ringer's solution, were performed safely with the use of moderate hypothermia. Hemodilution techniques are the key for the safe exocorporeal circulation and we set the lowest limit of body weight at 20 kg. Postoperative bleeding occurred in one case and was treated by early exploration. All the cases did not receive any blood or blood products during hospitalization. Therefore we can conclude that cardiac operations over 20 kg of body weight can be safely performed without any blood or blood products. With regard to social aspects, especially in case of emergency, we should make the decision regarding transfusion under the guidance proposed by the Japanese Medical Association.

Adolescent↗

[Combined aortic and mitral valve replacement with or without preservation of posterior mitral apparatus].

Seventy patients who underwent aortic and mitral valve replacement were reviewed. 37 patients had the mitral valve replaced with preservation of posterior mitral apparatus (AVR and modified MVR; modified group), and the others without (AVR and conventional MVR; conventional group). Hospital deaths occurred in 4 patients (12.1%) in conventional group and in only 1 patient (2.7%) in modified group. Four out of these five hospital deaths were due to low output syndrome (LOS). The other one died of unknown cause. Severe LOS, necessitating intra-aortic balloon pumping, occurred in 4 (12.1%) in conventional group and in 2 (5.4%) in modified group. In the early postoperative period modified group showed better left ventricular function than conventional group in terms of cardiac index and left ventricular stroke work index. Cardiac performance was evaluated by means of echocardiography at the time of discharge. Modified group showed better fractional shortening and shorter PEP/ET (pre-ejection period/ejection time). These findings suggest that the lower mortality of modified group is due to better left ventricular function preventing LOS in the early postoperative period, and that preserving the posterior mitral apparatus has a more beneficial effect on postoperative left ventricular function even in combined valve disease.

Aged↗

Continuous observation of nitric oxide production in the fetal rat brain during uteroplacental ischemia.

OBJECTIVES: To demonstrate real-time changes in nitric oxide (NO) production within fetal rat brain during uteroplacental ischemia and subsequent reperfusion. METHODS: Using a selective microsensor for NO, changes in NO electrocurrent in the brains of 10 fetal rats at gestational day 20 were observed during and after 30 min occlusion of uterine vessels in anesthetized pregnant rats. RESULTS: The NO electrocurrent reached 397 +/- 71.0% of the control level 30 min after occlusion and increased throughout the observation (p < 0.05) until placental administration of 1 M of L-NAME. In contrast, no significant changes in NO electrocurrent were found in 7 sham operated rats. CONCLUSION: An NO-specific microelectric sensor detected excessive NO production by fetal rat brains in response to uteroplacental ischemia.

Animals↗