Rhesus haemolytic disease treated with high-dose intravenous immunoglobulin.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to A Selbing.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The accuracy and precision of gestational dating, based on single measurements of the fetal biparietal diameter (BPD), was estimated in a consecutive series of 970 apparently normal, singleton pregnancies. The BPD sizes used varied between 11 and 60 mm, corresponding to 9-22 postconceptional weeks. The 'conceptual ages', used for reference, were estimated by means of ultrasonic measurements of the fetal crown--rump lengths (CRL). The association between the estimated conceptual age (dependent variable) and BPD size (independent variable) was found to be well represented (R2 = 0.972) by a second order polynomial: conceptual age = 44.7 + 1.069 X BPD + 0.01382 X BPD X BPD. To check the validity of the proposed equation, we used 23 fetuses conceived by artificial insemination with donor semen as controls. There was good agreement between the virtual conceptual ages of the control cases and their corresponding BPD-estimated conceptual ages (0.5 days mean difference, 3.6 days SD) when the suggested regression equation was used. The estimated precision of BPD-dating was minumum +/- 4.4 days (= +/- 2SD) at 9-10 completed postconceptional weeks. At 14 completed weeks the corresponding precision was found to be +/- 11 days (+/- 2SD). At the end of the studied BPD size interval, i.e. 56-60 mm BPD corresponding to 22 conceptual weeks, the precision was +/- 15 days. From an obstetrical point of view it seems obvious that the imprecision of gestational dating associated with BPD measurements greater than 35 mm should call for ultrasonic dating procedures to be performed earlier in pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
Explore the source record for details and available documents.
In a two-stage ultrasound screening program the gestational age was assessed by measurement of the fetal crown-rump length in early pregnancy. At an adjusted gestational age between 32 and 35 completed weeks the biparietal diameter, the abdominal circumference, the abdominal area and the ratio between fetal head area and abdominal area were estimated by means of ultrasound measurement. 'Acute' fetal weight was estimated by calculations from biparietal diameter and abdominal diameters. Percentile curves were constructed for these parameters and cut-off limits were tested for the predictability of intra-uterine growth retardation of the fetus. The abdominal circumference and area estimations were equally good for the detection of intra-uterine growth retardation. The biparietal diameter alone is of limited value for the detection of intra-uterine growth retardation but the combination with abdominal diameters in 'acute' fetal weight estimation can well be used. The ratio between the skull and abdominal areas seems to be of little use for the detection of intra-uterine growth retardation of two reasons: difficulty in measurement and low sensitivity. We consider that the assessment of gestational age in early pregnancy is a necessity both for the identification of suspected IUGR by means of ultrasound and the diagnosis of IUGR by measurement of fetal weight at birth. It is concluded that if the gestational age has been assessed by crown-rump length measurement in early pregnancy, a single estimation of the fetal abdominal circumference between 32 and 35 completed gestational weeks and a cut-off limit at the 15th percentile offers a detection rate of about 90% of the growth retarded infants.
Explore the source record for details and available documents.
A survey of triplet pregnancies in Linköping, Sweden, 1973-1981, showed a low perinatal mortality (4%) and low morbidity possibly due to prophylactic bed rest and tocolytic treatment. All children were followed at child health clinics. In one child, a persistent growth retardation was recorded at 4 years of age. No psychomotor deviations were found in the group. An interview concerning social and economic factors after delivery was carried out. The answers revealed considerable strain in daily life for all families.
Ultrasound screening for estimation of gestational age is one of the most important advances made in obstetrics. In this study on the effects of our crown-rump length (CRL) screening program, a most significant (25%) proportion of the pregnant women had a difference between menstrual age and gestational age estimated on the basis of crown-rump length, exceeding 7 days. Regular menstrual cycles and reliable menstrual history could only reduce this frequency to 19%. Postmature deliveries (greater than 294 days menstrual age) were reduced from one in fifteen to one in three hundred. A screening program with CRL is useless if the woman books in too late, since a CRL above 90 mm is unreliable because of differences in fetal bending of the spine. In our catchment area more than 78% of the women delivered booked early enough for a fetal CRL measurement. If this result can be expected in a population, CRL measurement should be used because of its better accuracy than biparietal diameter measurement for the estimation of gestational age.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The accuracy of conceptual age estimated by crown-rump length is not fully assessed by Robinson and Fleming in their excellent study. They avoid the problem by using the expression "menstrual maturity." We have evaluated predictors of fetal age from crown-rump length measurements where conceptual age was calculated either from the day of artificial insemination by donor (AID) or from the day of ovulation as judged from recordings of basal body temperature (BBT). When the date of AID was used as the conception date, better mathematical fits (R2 = 0.92) were obtained than when the thermal nadir was used (R2 = 0.86). The distribution around the regression line in the AID group is skewed with the 5th-95th percentile range being 3.7 days above the line and 7.3 days below the line. Similar results were obtained in the BBT group. Possible reasons for these findings are discussed.