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Biomedical subjects

A Senra

Publications and source records attributed to A Senra.

At least 19 recordsLinked to original sources
PubMed1991

[Ceruloplasmin levels in patients with chronic obstructive bronchopneumopathy].

The seric levels of ceruloplasmin in a group of 20 patients suffering of chronic obstructive lung disease were studied. Levels in this group of patients (51.42 +/- 11.15 mg/dl) (p less than 0.005) were significantly higher than those of the control group (36.59 +/- 13.37 mg/dl). There was no correlation between ceruloplasmin levels and PaO2, PaCO2, SaO2, HCO3- measurements. Results show a possible oxidation reaction; owing to the fact that ceruloplasmin is a general oxidase which, combined with an antioxidant stimulus of patients with chronic respiratory insufficiency, can produce this reaction.

Aged↗
PubMed1990

[Contribution to the study of the epidemiology of rheumatic diseases in our country and their occupational impact].

In a workforce of 8,149 workers, we reviewed the sick leave certificates issued over a period of 1 year. Amongst the absenteeism resulting from common diseases, 9.28% were of rheumatic nature (the second cause being respiratory viral infections). Furthermore, these rheumatic complaints were responsible for 14.66% days absenteeism from work, with a mean duration of 38.17 days, which was longer than for any of the other causes. In respect of accidents in the work place, 16.17% were influenced by rheumatic problems. These resulted in 18.77% days absenteeism with a mean duration of 33.94 days, which was greater than that relating to all other accidents. The total cost was close to 1.600 million pesetas.

Absenteeism↗
PubMed1990

[Effect of cimetidine on free fatty acid liberation].

Certain studies have brought to light the relationship between the administration of cimetidine and alterations of the lipidic metabolism. The changes in cholesterol levels observed after cimetidine administration have not yet been satisfactorily explained, at least in certain aspects. This paper studies free fatty acid behavior in a group of healthy volunteers who were given a 600 mg infusion of cimetidine. A significant drop (p less than 0.05) in fatty acids was found in these subjects in comparison with isolated physiological saline solution infusion. Our results imply that this fatty acid process may be involved in the lipid metabolism changes brought on by cimetidine administration.

Adipose Tissue↗
PubMed1990

[Results of the functional tests using calcitonin in patients with chronic diffuse hepatopathy].

A group of ten patients suffering cirrhosis who were treated with 100 U/l of calcitonin was studied with the aim of knowing whether in patients with cirrhosis the calcitonin is able to provoke the usual characteristic biologic modifications on the basis of the knowledge of their hormonal high levels accompanied of oesteopenia. Regarding their baseline determinations, no statistically significant modifications have been observed in calcium, phosphorous, alkaline phosphatase or its thermostable and thermolabile fractions, magnesium, uric acid and creatinine plasma concentrations respectively. This absence of a biological response to calcitonin could be due either to a numeric or functional damage of the hormone receptors or a diminished biodisponibility, although there are facts suggesting a lesser hormone biopotenciality in these patients.

Calcitonin↗
PubMed1989

[Changes in the activity of plasma renin and aldosterone induced by a pattern of increasing administration of zinc sulphate in normotensive individuals].

The behavior of the renin-angiotensin-aldosterone system was evaluated in response to an increasing zinc intake. This oligoelement can modify the activity of the angiotensin I converting enzyme (ACE). Six healthy normotensive volunteers received 30 mg of zinc sulphate orally for 4 days and 600 mg for 4 additional days. On the first, fifth and ninth days plasma renin activity (PRA) and serum aldosterone were measured, and the possible changes in blood pressure were evaluated. PRA and aldosterone showed significant increases, with a stepwise distribution throughout the zinc overload. On the first day, PRA was 0.40 +/- 0.08 ng/ml/h; on the fifth day it was 0.80 +/- 0.21 ng/ml/h, and on the ninth day 1.39 +/- 0.34 ng/ml/h (1st-5th day; p less than 0.05; 1st-9th day: p less than 0.02). On the first day, the aldosterone levels were 81 +/- 17 pg/ml, on the fifth day they were 119 +/- 26 pg/ml, and on the ninth day 164 +/- 30 pg/ml (1st-5th day: nonsignificant difference; 1st-9th day: p less than 0.02). The values of arterial pressure did not change significantly after zinc overload. It is concluded that zinc overload can modify PRA and aldosterone levels, and that these changes are dose-related.

Adult↗
PubMed1988

Biological changes in serum antiproteases as related to tumor progression.

The two major antiproteases (alpha-1-antitrypsin and alpha-2-macroglobulin) were studied in the serum of cancer patients (273 and 103 subjects, respectively) and in a control group. In cancer patients, the values were stratified by clinical stage (local, loco-regional and metastatic disease). Serum alpha-1-antitrypsin was different in normal people (341 +/- 110.7 mg/dl) than in every cancer group (p less than 0.0005). The behavior of alpha-2-macroglobulin was similar, with significant differences (p less than 0.0005) between normal people (317.6 +/- 105.4 mg/dl) and the cancer groups. Serum alpha-1-antitrypsin was different in local, loco-regional and metastatic disease; however, alpha-2-macroglobulin did not show these differences. In metastatic disease, sensitivity was 96.66% for alpha-1-antitrypsin and 94.79% for alpha-2-macroglobulin.

Female↗
PubMed1988

[Should the diagnosis of cancer be communicated to patients? Evaluation of a sample opinion survey of the Spanish population].

The aim of this paper is to determine the opinion of healthy individuals among whom might be future cancer patients, about communicating the diagnosis of this disease to the patients. An inquiry was performed on a representative sample of the spanish population. It covered 2493 persons over the age of 18. Two questions were asked: 1) "If you suffered from cancer would you prefer your physician to tell you or not?" 2) "If the cancer patient were a very near relative of yours (parent, etc.), would you wish the physician to inform the patient or not?" 69% gave a positive reply to the first question and 23% answered in the negative. The number of affirmative answers was significantly higher among the following groups: men (76%); young persons (82%); individuals with a high cultural level (79%; the unemployed (80%); and non-believers (86%). 42% answered "yes" to the second question and 44% answered "no". The number of affirmative answers was significantly higher among the following: men (48%); young people (54%); non-believers (65%); it was significantly lower among housewives (33%). The conclusion is that the diagnosis of cancer should not be communicated indiscriminately to the patient in all cases. The future problem lies in determining which persons should be informed of the diagnosis.

Adult↗
PubMed1987

[Evolution of breast cancer mortality in Spain].

A study is presented about the evolution of the breast cancer mortality in Spain between 1961 and 1980. This has been increasing strongly of several factors: 1) In actual increase of this disease, rising its adjusted death rates by age from 8/100,000 (1961) to 13/100,000 (1980) (increase = 62%); the truncated standardized rates between 35 and 64 years raised from 18/100,000 (1961) to 28/100,000 (1980): there is high correlation between both types of rates. 2) An increase of the female population at breast cancer risk (over 45 yr). A selective and significative rise of mortality from this cancer for the age groups under menopause, especially for the group 30-34 years (160%). The increase of female breast cancer mortality is statistically significant. It is necessary researching the causes of such increase.

Adult↗
PubMedDate not supplied

Changing patterns of gastric cancer mortality in Spain.

Time trends and the geographical variation of mortality from gastric cancer in Spain are analysed. The national (1961-1980) and the provincial (1975-1980) crude death rates as well as the age adjusted death rates were calculated using the population census (years 1960 and 1970) and the figures for national and provincial mortality. Mortality increased until 1963-1965 and then decreased significantly (P less than 0.01). Analysis of the geographic distribution reveals that the mortality rate is significantly higher in the interior than in the coastal provinces of the country, and higher in the provinces over 600 m above sea level.

Altitude↗