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Biomedical subjects

A Sere

Publications and source records attributed to A Sere.

9 recordsLinked to original sources
PubMed1994

[Purgative activity of Cassia italica].

Twenty guinea pigs were used to study the effects of Cassia italica leaves and pods extracts on intestinal motricity in vitro. The results obtained showed that the plant stimulate intestinal contractions with dose-dependent relation. Moreover, Cassia italica contractile activity was comparable to the acetylcholine one and was inhibited by atropine. According to these results, Cassia italica purgative activity is supported at least, by it's stimulating effect on intestinal motricity.

Acetylcholine↗
PubMed1993

[Antihypertensive action of Parkia biglobosa+ (Jacq) Benth seeds in the rat].

Hundred white Wistar rats have been used to evaluate the antihypertensive effects of entire seeds and decorticated, fermented seeds of a soudanian plant, Parkia biglobosa. The arterial blood pressure was measured by using bloody method in anesthizied animals. The Pham Huu Chanh method was used to determine type plant's antihypertensive activity. According to the results obtained, in both preparations, adequate doses decrease arterial blood pressure, diastolic more than systolic, but the effect of fermented seeds was more important than the entire seeds. In the two cases, the decrease in blood pressure is greated in hypertensive than in normotensive subjects, and the hypotension induced was well correlated with a bradycardia.

Animals↗
PubMed1993

[Choleretic effects of Cassia alata Linn in the rat].

Fifty rats weighing average 200 g were used to study choleretic activity of Cassia alata LINN extract. Bile was collected according to acute biliarly fistula technic on animals anesthetized with 1.5g/kg of ethyle carbamate (Urethane ND). After determination of the minimal active dose (15 mg/kg) and lethal dose (100mg/kg) of the extract, rats were allowed in 5 groups of 10 each one: one reference group, one group receiving 15 mg/kg of Hydroxycyclohexenyl-butyrate (Hebecol ND) a synthetic choleretic, and 3 groups receiving respectively 15 mg/kg, 30 mg/kg and 60 mg/kg of Cassia alata extract. According to results obtained, choleretic activity of Cassia alata at 15 mg/kg is better than the Hebucol ND ones. But at elevated doses, the plant tend to inhibit bile secretion.

Animals↗
PubMed1993

[Influence of dietary calcium/phosphorus ratio on blood calcium, phosphate and magnesium during gestation in the rabbit].

Sixteen Thiès strain rabbits were used to study the effect of the calcium/phosphorus ratio on plasma calcium, inorganic phosphorus and magnesium levels during pregnancy. Animals were allocated in 2 groups of 8: one receiving a diet with a Ca/P ratio of 1:0 and the other a diet with Ca/P ratio of 2:1. Water was given ad libitum for all rabbits. Results obtained showed that Ca blood level was significantly higher in rabbits receiving the diet with Ca/P ratio of 2:1 before covering and during the first week of pregnancy. During the last 15 d of pregnancy, Ca blood level decreased significantly in the 2 groups of animals. Plasma inorganic phosphorus and magnesium levels were not significantly different in the 2 groups of rabbits until the 2nd wk of pregnancy. But at the end of pregnancy, while phosphatemia and magnesemia decreased in rabbits fed a high Ca/P ratio, in the other group these parameters remained unchanged.

Animals↗
PubMed1990

[Influence of the season and of gestation on the plasma concentration of thyroid hormones: triiodothyronine (T3) and thyroxine (T4) in Sahel Peulh ewes].

Seasonal and gestational variations of triiodothyronine (T3) and thyroxine (T4) plasma concentrations were evaluated in 12 pregnant and 6 non pregnant adult Sahel Peulh ewes. Blood samples were drawn from all animals at different dates for radio-immunoassay. In this particular breed of sheep, plasma triiodothyronine and thyroxine levels did not present significant variations from the beginning of the cool season (December) until the end of the dry warm season (May). On the contrary, a highly significant rise of hormones (P less than 0.01) was observed at the onset of the humid warm season (June). Moreover, a significant decrease of thyroid hormone plasma levels (P less than or equal to 0.05) greater for thyroxine than triiodothyronine was observed at the end of gestation, particularly in twin pregnancies. At birth, the thyroxine plasma level was higher in single than in twin lambs (139.6 +/- 66.5 vs 110.5 +/- 43.8 ng/ml).

Animals↗