[Transesophageal electric stimulation of the left atrium in the diagnosis of ischemic heart disease in patients with arterial hypertension].
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Biomedical subjects
Publications and source records attributed to A Sh Gorshkov.
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To make a comparative assessment of transesophageal left atrial pacing (TLAP) and bicycle ergometry (BE) in the diagnosis of coronary heart disease (CHD) in patients with arterial hypertension (AH) of different origin, the authors examined 56 patients. The patients underwent TLAP and selective coronary angiography, of them 39 patients had BE testing. No significant differences were found in their specificity (73 and 78%) and sensitivity (92 and 81%) between TLAP and BE, respectively. The maximum heart rate in CHD patients with AH was significantly higher (130 +/- 6 per min) during TLAP than that in BE (112 +/- 5 per min, p > 0.05), ischemic changes occurring at the same value of double product despite the mode of myocardial ischemia induction in these functional tests (240 +/- 10 and 236 +/- 12 arbitrary units, respectively; p < 0.05). The mean systolic blood pressure was higher in TLAP and in BE (210 +/- 10 and 185 +/- 8 mm Hg). This follows that TLAP and BE finding are comparable and no profound changes occur in TLAP, hence it can be recommended for wide application in the diagnosis of CHD in AH patients.
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In atrial fibrillation, allapinine was shown to enhance rhythm by 7% and to increase cardiac output (p less than 0.05), as well as to slightly lower mean blood pressure and peripheral vascular resistance at rest. With exercise, both in atrial fibrillation, and sinus rhythm, there was a decrease in end-diastolic and end-systolic volumes of the left ventricle (p less than 0.05), a slight drop in ventricular ejection, that was statistically significant only with sinus rhythm (p less than 0.05). Physical exercise was not followed by an apparent additional aggravation of myocardial contractility, which makes allapinine preferable for long-term application to preserve sinus rhythm in patients without evident signs of heart failure.
The central hemodynamics was studied and compared in 20 patients with hypertrophic cardiomyopathy (HCMP) at rest, during bicycle ergometry (BEM) and transesophageal pacing of the atria (TEPA). According to the BEM readings, HCMP patients did not show any material differences from normals' reaction to exercise on the part of the volumetric and hemodynamic parameters as well as left ventricle contractile function. At the same time as revealed by TEPA, HCMP patients did manifest differences from normals' response in the hemodynamics and myocardial contractility. Alterations that occur in HCMP patients undergoing TEPA in response to an isolated increase of frequency of the cardiac rhythm are likely to reflect latent disorders of systolic function of the asymmetric hypertrophied left ventricle which is not capable of making adequate volumetric and functional restructure.
Twenty eight patients aged 31 to 56 years with Stages II-III chronic alcoholism were examined. All the patients underwent a thorough clinical, X-ray, and instrumental studies which provided the possibility to exclude coronary artery and valve diseases. Two-dimensional echocardiography revealed that chronic alcoholics had profound ventricular dysfunctions. The abnormalities in the right ventricle (its dilation and reduced ejection fraction) occur earlier than in the left one and they become deteriorated with lower left ventricular contractility.