Bible's stance on homosexuality. Bible shows no understanding of homosexual orientation as mutually supportive and affirming.
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Attitude↗
Biomedical subjects
A Sheard
Publications and source records attributed to A Sheard.
Homophobia in medicine
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Journal Article↗
Central motor conduction studies in hereditary spastic paraplegia.
Central motor conduction (CMC) studies were carried out in 25 patients with hereditary spastic paraplegia (HSP). Responses evoked in the lower limbs by transcranial magnetic stimulation of the motor cortex were bilaterally absent in 33% of the patients and, when recordable, were delayed in 75% of cases. Responses in the upper limbs were mostly normal except for those from the five members of one family, which were considerably delayed. There was no correlation between CMC parameters and age, duration of disease or upper limb hyperreflexia. CMC time to the tibialis anterior correlated with disability in patients with juvenile-onset HSP. It is concluded that CMC studies are not useful in detecting subclinical lesions in hereditary spastic paraplegia but may be of value in identifying subgroups of the disease.
Adolescent↗
Peripheral nerve dysfunction in scleroderma.
Peripheral neuropathy in patients with scleroderma is thought to be rare. We have undertaken a quantitative assessment of peripheral nerve function in 29 patients with either limited cutaneous scleroderma or progressive systemic sclerosis. Tactile thresholds were raised in the fingers in 28 per cent of patients and in the foot in 50 per cent. Two-point discrimination was abnormal in 10 patients, thermal thresholds were abnormal in five and vibration thresholds were abnormal in one. Nerve conduction studies showed abnormalities in six patients, five of whom had clinical signs of a mild peripheral neuropathy: the mean duration of disease in these six patients was 10 years longer than that in the remainder of the patients. There was electrophysiological evidence of a subclinical carpal tunnel syndrome in two patients. The sympathetic skin response was recorded in 16 patients who had not been subjected to sympathectomy for Raynaud's phenomenon, and was abnormal in four. These results indicate that peripheral nerve dysfunction in scleroderma, though mild, is not as uncommon as previously thought. The abnormal cutaneous sensory thresholds may be partly due to altered viscoelastic properties of the skin, but abnormal responses in the lower limbs to tests of tactile sensitivity, the clinical findings and the disturbances of nerve conduction argue in favour of an additional neuropathic process in some patients. Low grade distal nerve trunk ischaemia may be responsible.
Adult↗
A quantitative study of sensory function in hereditary spastic paraplegia.
Somatic sensation was studied in 23 patients from 14 families with hereditary spastic paraplegia. Quantitative sensory testing revealed significantly raised thermal, heat pain, vibratory and tactile thresholds in patients as compared with normal controls. Cutaneous sensitivity was more severely impaired in the feet than in the hand. All patients had at least one elevated sensory threshold. Sensory nerve conduction studies were abnormal in 6 patients, 5 of whom were members of the same family. Somatosensory evoked potentials were reduced on average to half the size of those of controls. Although the clinical picture is dominated by a spastic paraparesis, subclinical sensory impairment is common in hereditary spastic paraplegia and may reflect involvement of peripheral nerves, afferent pathways in the spinal cord or both.
Adult↗
Resistance to Eimeria bovis produced after chemotherapy of experimental infections in calves.
Eighteen Holstein-Friesian four week old calves were inoculated with 5 X 10(5) sporocysts of Eimeria bovis by stomach tube. The calves were divided into three equal groups. The first group was treated with monensin, 1 mg kg-1 body weight daily, from the 10th-20th day inclusive after infection; the second group was treated with amprolium, 10 mg kg-1 body weight daily, for the same period of time and the third group acted as infected controls. Both drugs were for the most part effective in preventing clinical signs, in suppressing reduced rates of weight and in reducing oocyst production. The calves of all three groups were resistant to the second infection given 35 days after the first infection with E. bovis as measured by rates of weight gain, fecal oocyst output and lack of clinical signs.
Amprolium↗