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A Sheehy

Publications and source records attributed to A Sheehy.

2 recordsLinked to original sources
PubMed1997

Both E12 and E47 allow commitment to the B cell lineage.

The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of B220+ cells, which lack immunoglobulin DJ(H) rearrangements. We have now generated mice expressing either E12 or E47. B cell development in mice expressing E12 but lacking E47 is perturbed at the pro-B cell stage, and these mice lack IgM+B220+ B cells in both bone marrow and spleen. IgM+B220+ B cells can be detected, albeit at significantly reduced levels, in the bone marrow and spleen of mice lacking E12. Ectopic expression of both E12 and E47 in a null mutant background shows that E12 and E47 act in concert to promote B lineage development. Taken together, the data indicate that both E12 and E47 allow commitment to the B cell lineage and act synergistically to promote B lymphocyte maturation.

Animals↗
PubMed1987

Spinal flexibility and individual factors that influence it.

We conducted an investigation to examine the spinal flexibility of a large, adult population and to study the effects of other individual physical characteristics on spinal range of motion. The study group consisted of 3,020 blue collar employees (2,350 men and 670 women) who underwent a physical examination that included assessments of standing and sitting height, weight, shoulder flexibility, and spinal flexibility in the sagittal and frontal planes. Flexibility measures were correlated positively to one another; however, lumbosacral flexion measurements assessed by the modified Schober method correlated to the other flexibility measurements to a much lesser degree. Age, sex, and height affected ROM, as did obesity and the ratio of standing height to sitting height. The study findings indicate that spinal ROM covers a wide spectrum of values and is affected by many individual factors. Any attempts to determine what is normal, excessive, or diminished must take into account variations caused by age, sex, and other physical attributes.

Adult↗