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Biomedical subjects

A Shirkhoda

Publications and source records attributed to A Shirkhoda.

87 records · Page 5Linked to original sources

Morphologic changes of the liver following chemotherapy for metastatic breast carcinoma: CT findings.

Thirty patients with metastatic breast carcinoma to the liver underwent systemic chemotherapy. Twenty-four of these patients also received hepatic arterial infusion chemotherapy, three in conjunction with hepatic artery embolization. The morphologic changes of the liver believed to be due to chemotoxic effect of treatment occurred in 27 patients, and were evaluated by serial computed tomography (CT) examinations. These included fatty changes in seven patients, severe cirrhotic changes in four, localized atrophy with regional contour changes in three, and areas of low density in the regions of previously treated metastases in 13. The CT features of cirrhosis included density changes along with nodular irregularity of the hepatic borders with marked decrease in liver size and development of ascites.

Adult↗

Cardiac arrest: abdominal CT imaging features.

We report computed tomographic findings of two unusual cases of sudden cardiac arrest. The imaging features documented include reflux of contrast into the abdomen as indicated by opacification of renal veins, hepatic veins, inferior vena cava, and hepatic and renal parenchyma. The reflux of contrast into the portal vein in one patient has not been described in the literature. The thoracic findings were reflux of contrast into the coronary sinus, nonopacificaton of the left ventricle with intravenous contrast, and lack of cardiac motion artifact.

Abdomen↗

Synovial sarcoma: MR imaging.

Ten patients with biopsy-proved synovial sarcoma were evaluated by magnetic resonance (MR) imaging on a 1.5-T unit. The lesions showed intermediate signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. Tumors were well-demarcated from normal tissues. Additional information included adjacent bone involvement (one case), femoral vein invasion by tumor (one case), and hemorrhage within the tumors (one case). Four patients underwent a repeat MR examination following chemotherapy. This showed a decrease in size and increase in the signal intensity of three tumors on T2-weighted images, proven to be due to necrosis in one. These changes correlated with clinical regression of disease. While MR in synovial sarcoma does not have any specific signal intensity, it proved to be useful in defining the extent of disease and in determining the response to chemotherapy.

Adolescent↗

Computed tomography after gastrectomy in primary gastric carcinoma.

Thirty-eight patients with adenocarcinoma of the stomach and considered disease-free following surgical resection of their primary neoplasm, underwent abdominal CT 1 month to 3 years after tumor removal. A total of 70 CT studies were obtained during this period. The most common findings were metastasis to lymph nodes (15 patients) and to the liver (nine patients). There were nine patients with local recurrence of the tumor. In the follow-up of patients after gastrectomy for carcinoma, CT was helpful in the diagnosis of local recurrence and distant metastasis, in guiding the biopsy of the suspected abnormalities, and in the evaluation of the results of treatment.

Adenocarcinoma↗

Computed tomography of choledochocele.

One case of choledochocele is reported, and the findings on CT, endoscopic retrograde cholangiopancreatography, and surgery are described. At surgery, in addition to choledochocele, a large choledochal cyst in the proximal common bile duct was discovered. Choledochocele can be diagnosed by CT and can be recognized by the finding of a cystic mass contiguous with the distal common bile duct that invaginates into the contrast-filled duodenum.

Adult↗

CT findings in hepatosplenic and renal candidiasis.

Fourteen patients with the diagnosis of leukemia and one with lymphoma developed systemic candidiasis. Involvement of the liver (15 patients), spleen (nine patients), and kidney (five patients) was diagnosed by clinical, CT, and pathologic findings. The CT findings ranged from low-density lesions (11 livers, nine spleens, and five kidneys) to hepatomegaly or hepatosplenomegaly. All livers and three kidneys had positive biopsy findings for Candida. Two patients with diffuse splenic lesions underwent splenectomy and were proven to have candidiasis. During a 1 year follow-up, two patients developed hepatic calcifications and one developed renal calcifications. In proper clinical setting, CT should be done for simultaneous evaluation of the liver, spleen, and kidneys. These studies, when positive, are useful to guide percutaneous or open biopsy and to follow the results of therapy. However, regardless of the hepatic CT finding, biopsy should be obtained to establish the diagnosis and begin proper treatment.

Adolescent↗

MR imaging of liposarcomas: correlation of MR features and histology.

The magnetic resonance (MR) imaging features of liposarcoma were correlated with histology in 15 patients. The MR findings for liposarcoma were not specific. The six myxoid liposarcomas and two atypical lipomatous tumors, however, had distinctive MR features, i.e., nodular masses of slightly heterogeneous intermediate to high signal intensity (SI), intermingled with high SI septa on T1-weighted images. The T2-weighted images demonstrated the relative reversal of these regional SI characteristics. Additionally, MR correctly identified the presence of fat in all eight cases in which it was pathologically present. The fat in two atypical lipomatous tumors was inseparable on MR from the subcutaneous fat. Magnetic resonance appears useful for preoperative staging and follow-up studies of liposarcomas. It may be helpful in identifying patients with myxoid liposarcoma and atypical lipomatous tumors who have longer survival times.

Adult↗

3D breath-hold contrast-enhanced MRA: a preliminary experience in aorta and iliac vascular disease.

PURPOSE: Our goal was to describe a 3D breath-hold (3D BH) contrast-enhanced MRA technique and apply the technique to patients with known or suspected aortic and iliac artery disease. METHOD: A fat-suppressed 3D GRE pulse sequence was designed with a total of 16 partition encodings. This took < 24 s for data acquisition in the abdomen and pelvis and was easily achieved during a single breath-hold. The technique was applied to 26 patients who presented with either known or suspected abdominal aortic or iliac vascular diseases. For comparison, in 19 patients a 2D TOF MRA pulse sequence with a traveling saturation band was used. Angiographic correlation was made in 18 studies. RESULTS: The 3D BH MRA was easily applicable in the evaluation of vascular anatomy and pathology. In three cases, it was superior to 2D TOF and conventional angiography for visualizing clot within the wall of an aneurysm in the abdominal aorta. In 20 cases, both MRA techniques overestimated the degree of stenosis in the lower peripheral vessels; however, this was more pronounced on 2D TOF. In five cases, the aneurysm wall was clearly defined by 3D BH MRA, whereas there was considerable signal loss in 2D TOF due to complex flow. With 3D BH MRA, the entire vessel territory both in abdominal aorta and in iliac vessels was visualized in all cases without signal falloff in the FOV. Breath-holding provided static images of the vessels that were free of blurring due to respiratory motion. CONCLUSION: Preliminary experience suggests that 3D BH with its distinct advantage of speed may serve as a useful screening tool for patients who cannot have conventional angiography or tolerate a lengthy MR examination of the abdominal aorta and iliac arteries.

Adult↗

Contrast-enhanced MR angiography of the mesenteric circulation: a pictorial essay.

Outstanding results have been achieved with magnetic resonance (MR) angiography, which has become competitive with conventional angiography as a vascular imaging technique. With the advances in gradient technology and the capability of imaging vessels in a single breath hold, one can track an intravenous bolus of paramagnetic contrast agent and evaluate the entire mesenteric circulation. Use of a breath-hold technique obviates the problem of motion artifact. Use of targeted maximum-intensity projection images from the three-dimensional (3D) volume data allows evaluation of the vascular anatomy at different phases (arterial and venous) of contrast enhancement. MR angiography performed with a contrast-enhanced breath-hold fat-suppressed 3D technique allows visualization of the superior mesenteric vessels, celiac artery, and portal vein in healthy subjects. Pathologic conditions of the mesenteric vessels that can be identified with this technique include stenosis or occlusion of the superior mesenteric artery, celiac artery aneurysm, thrombosis of the superior mesenteric vein, portal hypertension with varices, and vascular invasion by pancreatic carcinoma.

Adult↗

Fine needle aspiration cytology of thymolipoma. A case report.

A case of thymolipoma in a 14-year-old girl diagnosed prospectively by fine needle aspiration (FNA) biopsy is reported. The cellular constituents of the aspirate, lymphocytes and epithelial cells, were characterized by routine cytology and immunocytochemistry. Although primarily based on the FNA cytology, the diagnosis was supported by the patient's clinical history and the radiographic demonstration of a fat density mass. This appears to be the first description of thymolipoma in a fine needle aspirate.

Adolescent↗

Computed tomography of perirenal metastases.

The lymphatic and vascular network of the perirenal space is described. Eighteen cases of perirenal metastases are reviewed and examples of common pitfalls are illustrated. The pathways for metastases to the perirenal areas and explanation for other abnormalities are postulated.

Breast Neoplasms↗