Biomedical subjects

A Shukha

Publications and source records attributed to A Shukha.

3 recordsLinked to original sources

PubMed2002

Early detection of malignant process in benign lesions of breast tumor by measurements of changes in structuredness of cytoplasmic matrix in circulating lymphocytes (SCM test) reinduced in vitro by specific tumor antigen.

Early detection is crucial for successful treatment of all types of cancer. The specificity and sensitivity of the current methods vary from 50% to 80%. The use of specific tumor antigens and cytometric technology has resulted in the development of a new procedure for the early detection of breast tumors. This new method is reported. The test utilizes static cytometry, which records polarization and intensity changes in fluorescent light emitted from each individual lymphocyte obtained from tumor-bearing patients stimulated by the relevant specific tumor antigen. Using MUC-1/SEC as the specific antigen, we detected breast tumors with 85% specificity and 81% sensitivity in 137 breast tumor-bearing women. A significant linear correlation was found between the SCM test and the conventional classification of relative risk for breast cancer in benign lesions, suggesting that this is a precise method that could be used in mass screening for early detection of breast cancer.

Journal Article↗

PubMed2001

[Primary peritonitis due to Streptococcus pyogenes].

Most infections causing by Streptococcus pyogenes are known to be putrid both in adults and children, for example laryngitis, impetigo, cellulitis, scarlet fever, septic shock, toxic shock syndrome etc. Their clinical importance relates to a number of causes: 1) about 20% of the population are S. pyogenes carriers; 2) the clinical course of infections is often severe or even fatal; 3) there is real danger of nosocomial outbursts; 4) a world-wide increase in both the rate and invasiveness of the microbe. Acute primary peritonitis due to S. pyogenes seems to be a rare clinical event. In order to stimulate physicians' attention to the issue, we decided to describe the case of a child with the primary peritonitis due to S. pyogenes. Early diagnosis and surgical intervention combined with the proper antibiotic treatment appeared to be life-saving.

Cefuroxime↗

PubMed2001

[Stromal tumors of gastrointestinal tract: clinical and pathological features].

During the period 1991 till 1999, ten patients with primary stromal tumors of the gastrointestinal tract (stomach, duodenum, jejunum, ileum and rectum) were treated. Nine patients underwent radical resection and one patient had non-complete resection of the tumor. The median age of the group was 63 years for 7 male and 3 female patients. The median follow-up period was 58 months. The tumor size was 4.5-17 cm. (median 10 cm.) The median survival was 43 months. Five patients remained alive without the disease (median survival 87 months). One patient died with no evidence of the disease after 12 months. One patient remains alive with liver metastases for 13 months and 4 patients died of metastatic disease (median survival 10 months). Features associated with decreased survival included tumor size > 5-8 cm., mitotic counts > 5 mitotic figures per 50 high-power microscopic fields and high cellularity.

Female↗