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Biomedical subjects

A Siafakas

Publications and source records attributed to A Siafakas.

12 recordsLinked to original sources
PubMed2003

Acute psychosis due to treatment with phenytoin in a nonepileptic patient.

The development of psychosis related to antiepileptic drug treatment is usually attributed to the interaction between the epileptic brain substratum and the antiepileptic drugs. The case of a nonepileptic patient who developed psychosis following phenytoin treatment for trigeminal neuralgia is described. This case suggests that the psychotic symptoms that occur following phenytoin treatment in some epileptic patients may be the direct result of medication, unrelated to seizures.

Anticonvulsants↗
PubMed2002

Hemispheric predominance of abnormal findings in electroencephalogram (EEG).

The EEGs of 13,560 patients have been reviewed in order to determine whether abnormal findings, epileptiform or not, have a hemispheric dominance. We have included outpatients and hospitalized patients as well. Eight hundred and thirty-five EEGs had generalized abnormal findings, and 414 EEGs had lateralized abnormal findings. The EEGs of 322 patients (77.7%) had a left predominance, and those of 92 patients (22.3%) had a right predominance, of abnormal findings. A strong left predominance has been noted for the epileptiform discharges, i.e. 128 (79%) vs. 34 (21%). These results raise the possibility that the left hemisphere may be more vulnerable to nosological processes.

Adolescent↗
PubMed2000

Convulsive status epilepticus following abrupt high-dose benzodiazepine discontinuation.

The misuse of benzodiazepines (BNZ)s may result in serious side effects. Three cases of convulsive status epilepticus (CSE) following abrupt discontinuation of long-term use of 25 mg of lorazepam in one patient and more than 20 mg of flunitrazepam in two patients are presented; they were non-epileptics and free of other high-risk factors for seizures. A favorable outcome for all three cases was noted. They remain free of seizures without antiepileptic treatment. Nevertheless, because of the extensive use of benzodiazepines, such rare high-risk side effects must be emphasized.

Adult↗
PubMed2000

The usefulness of sleep and sleep deprivation as activating methods in electroencephalographic recording: contribution to a long-standing discussion.

Sedated sleep and sleep deprivation are commonly used methods to increase the diagnostic yield of the electroencephalogram (EEG), especially in the evaluation of people with epilepsy, but the rate of activation achieved by them is controversial, as is the issue of whether it is sleep itself, or sleep deprivation which is responsible for their alleged efficacy. We retrospectively studied the EEGs of epileptic patients, examined in our laboratory, who, after having undergone an inconclusive initial routine recording, had then been examined with a second recording. This was after either: (1) sleep deprivation with evidence of drowsiness in the recordings, (2) sleep deprivation without drowsiness (indicative of the effect which sleep deprivation per se has in eliciting abnormal patterns), or (3) drug-induced sedation. The activation rates found were (1) 22.5%, (2) 24% (22.6% for sleep deprivation collectively, regardless of the presence or not of subsequent drowsiness) and (3) 27% respectively. Only the sleep deprivation rate was statistically different from the 9.6% increased rate of abnormal patterns elicited by the simple repeating of a second routine recording, while the rate of drug-induced sleep was not. Although, sleep deprivation appeared to be more effective as an activating method of EEG compared with sedated sleep, no conclusions could be drawn about which stage of sleep, wakefulness or drowsiness, is primarily responsible for the method's efficacy.

Adolescent↗
PubMed1999

A case of fever following antiepileptic treatment.

A 23-year-old female patient treated with 900 mg oxcarbazepine for complex partial seizures is presented. Good seizure control and slight fever were noted a few weeks after drug administration. Reduction of oxcarbazepine and replacement with valproate resulted in a transient normothermia. Because of fever reappearance, vigabatrin was added and valproate was gradually reduced. Seizures reappeared, but the body temperature fell below 37 degrees C. Substitution of valproate for lamotrigine resulted in seizure control but abnormal body temperature (37- 37.6 degrees C) was noted again. Repeated hospital admission for clinical and laboratory investigation before any change of treatment revealed no other abnormal findings. The patient's abnormal temperature possibly reflects a derangement of high-level temperature control.

Adult↗
PubMed1986

[Contribution of visual evoked potentials, electronystagmography and the blink reflex to the diagnosis of multiple sclerosis].

One hundred and forty six cases of multiple sclerosis were investigated and classified according to McAlpine's criteria into 3 group: probable (40 cases), possible (51 cases) and definite (55 cases). In every patient visual evoked potentials, electronystagmography and blink reflex were performed in the same session. Percentages of abnormal findings were 66 p. cent for VEP, 63 p. cent for ENG and 53 p. cent for blink reflex. These 3 methods can detect subclinical lesions and in reveal new sites of demyelination. Since in only 14 cases (10%) were the results of all 3 methods normal, it is concluded that simultaneous examination by these methods can contribute to the diagnosis.

Adolescent↗
PubMedDate not supplied

Electrophysiological study (EEG, VEPs, BAEPs) in patients with Charcot Marie Tooth (type HMSN I) disease.

A laboratory investigation consisting of EEG recordings, BAEPs and VEPs evaluation as well as estimation of the facial nerve distal latency was performed in 9 patients who had Charcot Marie Tooth (type HMSN I) disease. 3 patients showed VEP's abnormalities (2 of them had prolonged P100 latency and one had an abnormal interocular latency difference). Another patient showed an upper normal limit value in the interocular latency difference. Abnormal BAEPs were found in 8 patients (one had I-III/IPLD prolonged, 2 of them had the latency of wave I prolonged and the remaining 6 had no readable or repeatable responses unilaterely or bilaterally). 7 out of 9 patients had the facial nerve distal latency prolonged, without any evident clinical facial weakness. Abnormal EEG recordings were found in 2 of all tested patients. Our results provide some evidence that in Charcot Marie Tooth disease the involvement of the II, VII and VIII nerves is more frequent than clinically expected and is probably related to a demyelinated process.

Adolescent↗
PubMedDate not supplied

Side-effects of lithium.

An account of the side-effects of 30 patients treated with lithium at Athens University Department of Psychiatry during the last two years is presented. The most frequent side-effects were: tremor of bands, polydipsia, polyuria, increase in appetite, dryness of mouth, general muscular weakness and memory reduction. Most side-effects were infrequent, mild and in no case necessitated discontinuation of treatment.

Bipolar Disorder↗