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Biomedical subjects

A Sibilly

Publications and source records attributed to A Sibilly.

63 records · Page 4Linked to original sources
PubMedDate not supplied

[Primary hyperparathyroidism. Round calcification as a sign of cervico-mediastinal localization of a parathyroid adenoma].

The authors report the case of a man aged 59 years, with primary hyperparathyroidism; removal of a first adenoma, did not lead to recovery. Later, an egg-shell calcification was found together with a second large cervico-mediastinal parathyroid adenoma, the removal of which caused all the symptoms to disappear. After a review of other cases in the world literature with calcification of the parathyroid glands, the authors consider, before using more complicated techniques for preoperative localisation of parathyroid adenomas, one should carry out careful radiological examination of the cervical and mediastinal region. Under these conditions, one may detect significant calcifications which have escaped routine examination and may contribute to the topographic diagnosis of the parathyroid lesion sought.

Adenoma↗
PubMedDate not supplied

[Effects of vagotomy and pyloroplasty on a model of experimental chronic gastric ulcer in the rat (author's transl)].

343 white Wistar rats were divided into three groups of 113, 115 and 115 animals in each group. A control group received an injection of acetic acid into the wall of the antrum whereas the two other groups underwent first, in one group, a vagotomy and pyloroplasty, in the other, a pyloroplasty alone. In all the control animals there was observed, during the days following the injection, the existence of a severe antral ulcer. This ulcer improved with time upon 40th day, then around the 70th day appeared a second ulcer cycle. In the operated animals, the ulcers were definitively less frequent, and the course was linear without a second ulcer cycle. In the light of physiological and morphological evidence, it was shown that injection of acetic acid caused a submucosal lesion with a constant linear course towards the development of a callus which became hyalinised all the more quickly when it was submitted to endogenous agression by gastric juice. Above this callus, the gastric mucosa attempts to regenerate and, owing to the poor quality substratum, becomes ulcerated again, thus constituting the various cycles of peptic ulcer disease. Pyloroplasty and to a lesser degree, vagotomy-pyloroplasty, reduce stasis of the gastric juice and reduce endogenous agression of the callus and thus slow the unfavourable course.

Acetates↗
PubMedDate not supplied

[Cystadenoma of the pancreas. Study of the angiogenesis and the associated diseases (author's transl)].

We describe a case of pancreatic cystadenoma (PC) concerning a 66 year-old woman. This PC was a highly vascular cystic tumor, with typical signs: pulsatile tumor, systolic epigastric souffle and demonstrative phonangiography; the selective angiography revealed a hypervascular mass. Microscopically, tiny cysts lined by small, cuboid and columnar cells containing no glycogen, and numerous capillaries. With this case and 210 cases from the literature, two problems have been studied in this paper: the problem of the vascularity of the PC and the problem of the associated diseases. The vascularity allows to distinguish two types of PC: PC with hypervascular pattern and hypo- or avascular PC. The study of the associated diseases shows the high incidence of the tumors (23%), benign and malignant (13%) and of the cysts in other organs (5%). Comparison with polycystic disease of the kidney and the Von Hippel-Lindau disease and hypothesis concerning angio-genesis and cystogenesis in the PC are discussed.

Angiography↗
PubMedDate not supplied

[Primary linitis plastica carcinoma of the colon and the rectum. Report of three personal cases (author's transl)].

Primary linitis plastica carcinoma of the colon is rare. Only 19 cases have previously been described in the american literature and three french cases are reported. Clinically, this entity appears as an inflammatory lesion. It revolves to a stenotic lesion and death by metastases. Eighty-four per cent of carcinomas are beyond the splenic angle and sixty-six per cent are localized on rectum or distal sigmoid. These tumours are accessible to rectoscopic examination and biopsy which is the only examination able to assert the diagnosis of linitis. Histologically, nothing can distinguish a primary colonic localization from a metastasis. Therefore, it is very important to search for a primary localization especially gastric. Surgical resection is efficient with or without X ray-therapy as we have seen it with control of carcino-embryogenic antigene evolution in one of our cases. Prognosis is bad, especially among people over 50 years with metastasis.

Adenocarcinoma, Scirrhous↗