[Suddenly occurring exotropia with nystagmus in a 5-year-old girl].
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Acute Disease↗
Biomedical subjects
A Siennicka
Publications and source records attributed to A Siennicka.
Simvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cells.
Adhesion and transendothelial migration of leukocytes into the vascular wall is a crucial step in atherogenesis. Expression of cell adhesion molecules by endothelial cells plays a leading role in this process. We investigated the effect of simvastatin, an inhibitor of HMG-CoA reductase administered to reduce plasma levels of LDL-cholesterol, on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular cell adhesion molecule-1 (ICAM-1) by human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor alpha (TNFalpha). We found the expression to be significantly inhibited by the drug in a time and concentration-dependent manner and to a greater extent in the case of VCAM-1 as compared with ICAM-1. In TNFalpha-stimulated HUVEC, simvastatin decreased VCAM-1 and ICAM-1 mRNA levels, inhibited TNFalpha-induced activation of nuclear factor kappaB (NF-kappaB) and enhanced expression of peroxisome proliferator-activated receptor alpha (PPARalpha). These effects were associated with reduction of adherence of monocytes and lymphocytes to HUVEC. The present findings suggest that the benefits of statins in vascular disease may include the inhibition of expression of VCAM-1 and ICAM-1 through effects on NF-kappaB.
Cell Adhesion↗
[Trichotillomania--case report].
This paper presents a case of trichotillomania involving the eyelids and eyebrows. This is a chronic illness that may be difficult to treat. The most common approach consists of pharmacotherapy and psychotherapy combination. Trichotillomania, classified in DSM IV as an impulse control disorder is characterized by an irresistible urge to pull hair, accompanied by a build up of tension and subsequent sense of relief. The mean age of onset is 8 years for males and 12 for females. Hair is pulled from a variety of sites, most frequently from the scalp but also eyelashes, eyebrows, beard, armpit and the pubic area.
Adult↗