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Biomedical subjects

A Sierro

Publications and source records attributed to A Sierro.

4 recordsLinked to original sources
PubMed1991

[Prevention of vascular thromboses after renal transplantation using low molecular weight heparin].

Vascular thrombosis is one of the main causes of early transplant failure in pediatric patients. This paper reports the results of an open trial of the low molecular weight heparin (Enoxaparine) used to prevent renal graft thrombosis in pediatric recipients with risk factors including donor or recipient age under 5 years, multiple arteries supplying the transplant, and positive history for recurrent thrombosis. During 1989, 42 of 67 children given a renal transplant were prophylactically treated with Enoxaparin. Only one transplant was lost to thrombosis among treated patients (1.5%), versus 9 transplants among 73 (12%) children who received their kidney in 1988 without prophylactic Enoxaparin. Risk factors were comparable in both groups of recipients. Enoxaparine therapy was associated with an increased rate of bleeding (12/42) without severe consequences. In conclusion, Enoxaparin is effective in preventing renal graft thrombosis. Availability of this prophylactic therapy makes it possible to use transplants removed from the youngest donors considered as inadequate by some groups.

Age Factors↗
PubMedDate not supplied

[Recurrent bacteriuria in children].

Fifty-four children admitted to the Children's Hospital of Cordoba City with recurrent bacteriuria were followed for 12 to 97 months. Most of them were females and Escherichia coli was the most frequent microorganism isolated in recurrent attacks of bacteriuria. Ninety percent of the patients showed urological abnormalities. Vesicoureteral reflux was the most frequent. Residual urine was considered the main cause of recurrent bacteriuria. After antibioticotherapy and surgical treatment, over one half of the patients persisted with relapses. Recurrent bacteriuria appeared more frequently in male infants with severe urologic abnormalities. Finally, three groups of patients in relation to uropathy and functional renal impairment are described and a different prognosis for each one is proposed. For this reason, each patient must have a complete urologic examination done at the onset and a carefull follow-up, carried out.

Bacteriuria↗
PubMedDate not supplied

[Pyelonephritis in children].

Fifty cases with pyelonephritis were found among 1314 histopathologic studies performed at Children's Hospital of Cordoba, Argentine from 1967 to 1976. Twenty-six had urologic abnormalities. Most of them were males over two years old. Eleven had unilateral pyelonephritis. Twenty-four had clinical and pathological signs of septicemia or infection. No sex difference was found and most of them were infants under two years of age. All patients had bilateral pyelonephritis. Twenty-four patients showed positive urine culture before death. They also showed clinical features, urinary concentration inability and pyelographic changes that suggest pyelonephritis. Our conclusions are that pyelonephritis is not common among children, and appeares only associated with systemic infection or urologic abnormalities. Clinical signs, urinary examination and intravenous pyelography are useful in the diagnosis of pyelonephritis.

Child↗