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Biomedical subjects

A Simard

Publications and source records attributed to A Simard.

At least 37 records · Page 2Linked to original sources
PubMed1993

A population-based case-control study of cancer of the bile ducts and gallbladder in Quebec, Canada.

In a population-based case-control study of pancreatic cancer in Greater Montreal between 1984 and 1988, a total of 24 patients with cancer of the bile ducts and 33 patients suffering from cancer of the gallbladder were compared to 239 population-based controls. This study was part of the SEARCH program of the International Agency for Research on Cancer. In cases of cancer of the bile ducts, smoking nonfiltered cigarettes produced a relative risk of 2.82 and a 95% confidence interval of 1.01-7.86 after adjustment for age, sex, other smoking habits, alcohol consumption, schooling, and respondent status. Laxative intake was associated with a risk of 2.87 (1.00-8.22). Coffee drinkers were collectively at lower risk than non-drinkers: OR = 0.26 (0.07-0.95). In patients with cancer of the gallbladder, constipation was related to a risk of 3.19 (1.02-9.95) after adjustment for the same factors. In cases with previous gallbladder problems, the risk was found to be significant [OR = 7.96 (2.03-31.2)], 8 times greater in cases than in controls.

Adult↗
PubMed1992

A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme.

Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.

Adult↗
PubMed1992

[Diabetes mellitus and pancreatic cancer: a case-control study in greater Montreal, Quebec, Canada].

In a population-based case-control study of dietary risk factors in French Canadians in Montreal, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. It was found that the frequency of diabetes was almost three times higher in cases of pancreatic cancer (16%) than in the controls (6%), with an Odds Ratio (OR) of 2.52 and a Confidence Interval (CI) of 1.04-6.11. Fifty per cent of the pancreatic cancer cases had this disease before the cancer was diagnosed, compared with 71% of the controls at the time of the study. Those aged 50 years and over accounted for 75% of the cases and 71% of the controls (diabetic subjects); 68% of the cases were treated with a combination of diet and oral hypoglycemic agents compared with 86% of the controls. Insulin was used by 32% of the cases and 14% of the controls. These results suggest that diabetes may play a major role in the etiopathogenesis of pancreatic cancer in this urban population. A lot of controversy remains about the precise role of diabetes, and further studies are needed for a better assessment and understanding of the mechanisms of this association.

Adult↗
PubMed1991

Tobacco, alcohol, and coffee and cancer of the pancreas. A population-based, case-control study in Quebec, Canada.

A population-based, case-control study of pancreatic cancer was carried out in greater Montreal between 1984 and 1988. A total of 179 cases and 239 population-based controls were interviewed. This study was part of the SEARCH program of the International Agency for Research on Cancer of the World Health Organization. A strong positive association was observed between total cigarette smoking and risk of pancreatic cancer (odds ratio [OR] = 3.76; 95% confidence interval [CI], 1.80 to 7.83). The OR for current smokers in the highest quintile of number of cigarettes was 5.15 compared with 3.99 for exsmokers. Those who consumed alcohol were in general at lower risk than nondrinkers. Coffee drinkers were collectively at lower risk than nondrinkers, particularly when coffee was consumed with meals, not on empty stomach.

Adult↗
PubMed1991

Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada.

In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, response status, lifetime cigarette consumption and energy intake, there appeared to be an association with total fat intake (odds ratio in highest quartile relative to lowest quartile 2.24 [95% Confidence Interval (0.74, 6.73)] and, particularly, saturated fat [OR = 4.32, 95% CI(1.39,13.7)]. Although dietary cholesterol intake appeared to increase risk and a number of many micro-nutrients were apparently associated with reductions of risk, none were statistically significant. The results are consistent with a role of nutritional factors in the etiology of pancreatic cancer. The magnitude of the risks involved emphasizes the necessity for larger studies of this topic.

Adult↗
PubMed1990

Nutrition and lifestyle factors in fibrocystic disease and cancer of the breast.

Within a study on diet as a risk factor for fibrocystic disease and breast cancer, 68 patients with breast cancer, aged from 40 to 59, participating in the National Breast Screening Study in Montreal, were compared to 340 patients with fibrocystic disease and to 343 controls. The personal and family history was collected from medical records and completed by an interview. The nutritional assessment was done by a food frequency questionnaire with a special attention to the quantity and quality of fat, vitamins A, C, E, as well as life style habits. The cancer patients were significantly heavier (64.9 vs. 60.8 kg), had higher body mass index (24.9 vs. 23.4), menstrual cycle more often irregular, later menopause (47.5 vs. 44.5 years), and shorter school attendance (10.3 vs. 12.6 years). No significant differences were found in the use of contraceptives, menopausal hormones, analgesics and tobacco, marital status, number of pregnancies and children, age at menarche, duration of menstrual cycle, and the age at the first pregnancy. The cancer patients consumed significantly more poultry, fish, pastry, margarine, and alcohol and less milk, raw vegetables, pastas, sugar, butter, and coffee.

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PubMed1988

[Geography of cancer of the esophagus].

A review of available data on the epidemiology of oesophageal cancer from different parts of the world as well as an analysis of new findings, suggests the following conclusions: 1. A peculiar incidence pattern of the disease exists worldwide with roughly 500-fold differences in rates (truncated) between the highest and lowest risk areas. 2. Males are generally affected more than females, with a few exceptions such as the very high risk regions of northern Iran. The highest male: female sex ratios (based on truncated incidence rates) have been reported from Normandy and Brittany (25:1) and the lowest ratios from South Gorgan in northern Iran (0.5:1). 3. There is evidence that the frequency of oesophageal cancer is rising over time in many regions, particularly among the black population of the United States and in England and France. 4. Most of the areas reflecting a very high incidence of this disease are located in poorer parts of the world. 5. The frequency of this disease varies among the native and migrated population in different countries.

Cross-Cultural Comparison↗
PubMed1984

Pulmonary cytology in chrysotile asbestos workers.

The prevalence of atypical cytology has been determined in relation to age, smoking and asbestos exposure for male workers employed in 3 mines in the Province of Quebec. Overall participation was 71%. Out of 867 participating workers, 626 (72%) presented a deep cough specimen within normal limits, 74 (8.5%) a specimen with mild atypical metaplasia and 10 (1.2%) a specimen with moderate atypical metaplasia. Four lung carcinoma were identified. Five percent of the workers initially interviewed did not return their specimen and 12.7% had unsatisfactory test results. Proportions of cellular atypia increased with age and asbestos exposure. Using logistic regression analysis, estimated probabilities of abnormal cytology for workers aged 25 years when started mining increased with both years of asbestos exposure and exposure index measured in fibres per cubic centimeter.

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PubMed1983

Pulmonary cytology in foundry workers.

The prevalence of cellular atypias has been determined in relation to smoking history, age and type of work of male foundry workers in different departments of a foundry. Participation of the workers was 95%. Out of 677 workers, 528 had results within normal limits, 36 showed mild atypical metaplasia while 4 persons got moderate atypias; 48 individuals showed unsatisfactory results and 61 did not complete the tests. Prevalence of abnormal findings ranged from 4.2% in non-smokers to 7.8% in smokers of more than 21 cigarettes. The prevalence also increased with age in smokers only. Variations in prevalence associated with employment in different departments of the foundry varied little and were not statistically significant.

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