Clinical aspects of indolealkylamine metabolism. Introductory remarks.
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Humans↗
Biomedical subjects
A Sjoerdsma
Publications and source records attributed to A Sjoerdsma.
Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome.
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Adult↗
Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor.
Development of a rapid and sensitive radioassay has permitted study of the conversion of tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef and rat pineal gland contained the highest activity. This is the first direct demonstration of tryptophan hydroxylase in this hydroxyindole-rich tissue. Rat and rabbit brainstem and human carcinoid tumor also had quantities of enzyme that could be measured easily. The reaction requires a reduced pteridine and oxygen and is inhibired by Para-Chorophenylalanine.
Animals↗
Origin of urinary tyramine and tryptamine.
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Anti-Bacterial Agents↗
Characterization of a tryptophan hydroxylating enzyme from malignant mouse mast cell.
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Animals↗
Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.
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Animals↗
End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.
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Animals↗
Effect of penicillamine on human collagen and its possible application to treatment of scleroderma.
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Adult↗
Collagen profile in various clinical conditions.
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Adolescent↗
A modified procedure for radioactive hydroxyproline assay in urine and tissues after labeled proline administration.
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Animals↗
Attacks simulating pheochromocytoma in patients with angina pectoris.
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Angina Pectoris↗
Effect of catecholamines and adrenergic blocking agents on oxidative phosphorylation in rat heart mitochondria.
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Animals↗
Effect of parathyroid extract on collagen metabolism.
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Animals↗
Elevated plasma levels of a hydroxyproline-containing protein in Hodgkin's disease and their relation to disease activity.
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Adolescent↗
Catecholamine-drug interactions in man.
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Carboxy-Lyases↗
Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.
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Adrenal Medulla↗
Increased synthesis of norepinephrine in the rat heart on electrical stimulation of the stellate ganglia.
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Animals↗
Urinary homovanillic acid in phaeochromocytoma.
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Adult↗