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Biomedical subjects

A Sklavounou

Publications and source records attributed to A Sklavounou.

At least 19 recordsLinked to original sources
PubMed2000

TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation.

Apoptosis appears to be the mode of cell death by which damaged cells are removed from the lesional tissue in oral lichen planus (OLP). In the present study, OLP biopsies were immunohistochemically evaluated for TNF-alpha and apoptosis-regulating proteins in an attempt to compare their phenotypic expression. Deparaffinized tissue sections from 22 OLP and 10 control oral biopsy specimens were immunohistochemically stained with anti-Bcl-2, anti-Bcl-x, anti-Bax and anti-TNF-alpha antibodies. Keratinocytes did not show any immunoreactivity for Bcl-2, while a uniform intense staining for this protein was evident in the lymphocytic infiltrate of OLP specimens. Immunoreactivity for TNF-alpha was seen in 17/22 OLP cases. All control tissues were TNF-alpha negative, thus indicating a possible involvement of this cytokine in the pathogenesis of OLP The differences in the staining intensities of Bcl-x and Bax between OLP and normal epithelium were slight; therefore an obvious association of the phenotypic TNF-alpha expression with these apoptosis-regulating proteins was not apparent.

Adult↗
PubMed1998

Paraneoplastic pemphigus: a review.

Paraneoplastic pemphigus (PNP) is a relatively recently described autoimmune disorder, distinguished from pemphigus vulgaris or foliaceus by specific clinical, histologic and immunologic criteria. In the present review, 18 cases of paraneoplastic pemphigus reported so far are discussed. The polymorphism, extent and persistence of skin and mucosal lesions are discussed while the problems of differential diagnosis and the significance of the associated neoplasms are also stressed. The underlying malignancy in the majority of the cases has been of lymphoid origin and has preceded the clinical presentation of pemphigus. All patients have had oral and cutaneous lesions. In 66.6% of the patients there was a poor response to therapy.

Aged↗
PubMed1994

True fibroma of the oral mucosa: a case report.

A case of true fibroma of the maxillary alveolar mucosa in a 44-year-old woman is reported. The clinical and histologic criteria for its distinction from irritation fibroma are discussed.

Adult↗
PubMed1994

Alteration in peripheral blood mononuclear cell function and serum cytokines in oral lichen planus.

Different activation parameters of peripheral blood mononuclear cells (PBMC) from 31 patients with oral lichen planus (OLP) were examined and compared with 23 healthy donors. Impaired spontaneous (450 +/- 241 vs 1290 +/- 480 cpm) and mitogen-induced (39580 +/- 14470 vs 67000 +/- 11810 cpm) lymphocyte blastogenesis was observed in OLP patients. Furthermore, reduced cytokine production was found after phytohemagglutinin A (PHA) stimulation for all cytokines studied-tumour necrosis factor alpha (TNF alpha, 432.2 +/- 73.4 vs 979.8 +/- 46.3 units/ml), interleukin 2 (IL-2, 156.2 +/- 14.9 vs 572.6 +/- 12.9 pg/ml), interferon gamma (IFN gamma, 48.5 +/- 11.9 vs 82.6 +/- 12.4 pg/ml) and interleukin 6 (IL-6, 253.6 +/- 57.7 vs 1,419.0 +/- 279.6 units/ml)-except for interleukin 1 beta (IL-1 beta) and lymphotoxin (LT). In contrast, unstimulated culture supernatants showed increased TNF alpha (38.2 +/- 13.1 vs 8.0 +/- 0.2 units/ml), LT (10.2 +/- 2.2 units/ml vs < 0.4) and IL-6 (18.5 +/- 5.6 units/ml vs < 0.5) activity. Similarly, elevated concentrations of TNF alpha (19.6 +/- 6.3 units/ml) and IL-6 (22.9 +/- 4.7 units/ml) were detected in the sera of OLP patients. Combination of PHA and phorbol myristate acetate (PMA) could restore OLP proliferative T cell response and cytokine production to the level of healthy donors, whereas exogenous recombinant human IL-2 (rhuIL-2) plus PMA did not seem to be an effective stimulant for OLP T cells. These results indicate an alteration in the immune condition of OLP patients and an impairment in T lymphocyte function.

Adult↗
PubMed1990

Oral psoriasis: report of a case and review of the literature.

Psoriasis is a chronic inflammatory skin disease which very rarely affects the oral mucosa. In the present article, an interesting case of psoriasis with exclusive oral involvement is described. The patient's history, clinical, microscopic features, and HLA typing were consistent with a diagnosis of psoriasis. A review of the 68 reported cases of oral psoriasis is presented in table form.

Adult↗
PubMed1990

[Oral condyloma acuminatum: a rare viral epithelial lesion. Report of two cases and a review].

Condyloma acuminatum is a benign, sexually transmitted papillary lesion, primarily found in the anogenital region. Although reports of oral condyloma acuminatum are appearing more frequently, they still are sparse. The lesion is caused by the Papova virus and the differentiation from other papular growths of the oral cavity is often difficult. In the present study two histologically documented cases of the lesion are presented and the clinicopathologic features of all cases with oral involvement reported in the literature are analyzed.

Adult↗
PubMed1990

[Molluscum contagiosum].

Molluscum contagiosum is a common disease of the skin caused by a virus of the pox group, most commonly seen in children. The lesion is very rare in the oral cavity, since review of the English literature revealed only 5 documented cases. Oral lesions have no pathognomic clinical picture and may cause diagnostic problems.

Child, Preschool↗
PubMed1990

[Linear IgA bullous dermatosis (LABD): a recently recognized entity].

In previous years linear IgA bullous dermatosis (LABD) of the adults has caused considerable discussion as to its classification. Some investigators considered LABD to be a subgroup of pemphigoid and others regarded it as being more closely related to dermatitis herpetiformis. However a growing body of evidence points to LABD as a distinct disease entity which is characterized by IgA staining along the basement membrane zone in a linear pattern (Chorzelski et al 1979). In this paper a review of this newly recognized entity is attempted, based on the reports from the literature. The clinico-pathologic and immunologic features of LABD are analyzed and discussed and emphasis is given to the problem of differential diagnosis with other bullous dermatoses.

Dermatitis Herpetiformis↗
PubMed1989

Familial pemphigus vulgaris with oral manifestations affecting two Greek families.

Two families of Greek origin with oral pemphigus vulgaris are reported. Both are fully documented cases of familial pemphigus in Greek Mediterranean patients. In the first family, a sister and a brother developed oral mucosal pemphigus lesions within a 5-year period, and a cousin had died from the disease 20 years earlier. In the second family, a daughter, a son and their mother developed the disease 2, 4 and 6 years apart. HLA typing has been performed and disclosed striking associations and similarities between the members of each family. Review of the fully documented cases of familial pemphigus vulgaris is also presented in a tabular form.

Adult↗
PubMed1989

[Myxoma of the mandible. Report of a case].

Myxoma is a benign tumor of the jaws of mesenchymal origin. A case of such a lesion of the mandible is reported, which was treated by peripheral ostectomy through an oblique-buccal incision, with satisfactory functional and aesthetic results.

Adult↗
PubMed1985

Loss of intercellular substance antigens in oral hyperkeratosis, epithelial dysplasia, and squamous cell carcinoma.

Tissues from 20 oral squamous cell carcinomas and 32 leukoplakic lesions were investigated for the presence of intercellular substance antigens by the indirect immunofluorescent technique using sera from patients with proven pemphigus vulgaris. The leukoplakic lesions included 19 hyperkeratoses without histologic evidence of dysplasia and 13 hyperkeratoses with varying degrees of epithelial dysplasia. Oral tissues from 20 healthy subjects were included as a control group. The great majority of squamous cell carcinomas (95%) showed partial or complete loss of the intercellular substance antigen reactivity. Similarly, hyperkeratoses with dysplasia demonstrated, in 92% of the cases, decreased or complete absence of intercellular substance antigen reactivity. Furthermore, the degree of antigenic loss seemed to be directly related to the degree of cellular anaplasia. On the other hand, in the hyperkeratosis group without histologic signs of epithelial dysplasia, retention of normal intercellular substance antigenic pattern was observed in 73.7% of the cases as compared to the control specimens. The authors suggest that further studies are necessary to assess what value lies in determining the loss of epithelial antigens in predicting the malignant potential of dysplastic oral epithelium.

Antigens↗
PubMed1985

Warty dyskeratoma of the oral mucosa.

A case of oral warty dyskeratoma is presented and the literature is reviewed in brief. While warty dyskeratoma of the oral mucosa is rare, it appears to exhibit a variability of clinical appearance and to have a special predilection for keratinised mucosae exposed to friction and mechanical stress.

Darier Disease↗
PubMed1984

Molluscum contagiosum of the oral mucosa.

A case of molluscum contagiosum involving the buccal mucosa is reported. A review of the literature disclosed only two documented cases of this tumor with oral involvement, emphasizing its rare occurrence in the oral cavity.

Adult↗
PubMed1984

Eosinophilic ulcer of the oral mucosa.

Two additional cases of eosinophilic ulcer of the oral mucosa are presented. Both patients were treated with corticosteroids, with favorable results. A review of the literature provided useful information on the clinical characteristics, histologic features, method of treatment, and benign course of the lesions.

Adult↗
PubMed1983

Frequency of desquamative gingivitis in skin diseases.

In an attempt to determine the frequency of desquamative gingivitis (DG) in pemphigus vulgaris (PV), bullous pemphigoid (BP), cicatricial pemphigoid (CP), and lichen planus (LP), a large series of patients examined and classified in each group during the years 1972 to 1981 were included in this study. Analysis of the clinical data revealed that, of the four skin diseases, CP manifests as DG in 63.6 percent of the cases. Desquamative gingival lesions are less frequent in LP (25 percent) and in PV (18.4 percent). The great majority of DG patients were females (72.9 percent). Identification of the underlying causes of desquamative gingivitis is of utmost importance and is dependent upon clinical, histologic, and immunologic criteria.

Aged↗
PubMed1982

Bullous pemphigoid, cicatricial pemphigoid, and pemphigus vulgaris. A comparative clinical survey of 278 cases.

The clinical features of bullous pemphigoid (BP), cicatricial pemphigoid (CP), and pemphigus vulgaris (PV), based upon examination of 278 patients during the years 1972 through 1981, are recorded. Data in relation to age, sex, site of onset, duration of the disease at the site of onset, distribution of oral, skin, and extracutaneous lesions, and time of final diagnosis are analyzed for each disease separately, and a detailed discussion in comparison with previous reports follows. Comparative evaluation of all the clinical data permitted identification of similarities and differences in the clinical manifestations within this disease group and provided an opportunity to increase our knowledge and understanding of the overall clinical behavior of these bullous diseases. Greater awareness of these entities, which very often involve the oral mucosa, in correlation with careful clinical observation is of particular importance and leads to early diagnosis and improved treatment.

Adolescent↗
PubMed1982

Direct immunofluorescence in oral lichen planus.

Direct immunofluorescent staining (DIF) was performed on biopsy specimens from thirty-five patients with oral lichen planus. The results showed fibrin deposition in all cases at the mucosal-submucosal interface, within colloid bodies (fourteen of thirty-five) and within vascular walls (five of thirty-five). Deposition of IgG, IgA and IgM was detected to a lesser extent, while complement (C3) could not be identified in any case. The significance of these findings was assessed by comparison with the IF results obtained in thirty-five biopsies from various oral diseases other than lichen planus and ten healty persons. Although the presence of fibrin deposition at the mucosal-submucosal junction, within vessels and cytoid bodies, was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were also seen in lupus erythematosus. It is known at present whether immunologic reactions may play a role in the pathogenesis of lichen planus. However, the immunopathologic findings may occasionally be additional suggestive markers in the diagnosis of the disease.

Complement C3↗