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Biomedical subjects

A Smart

Publications and source records attributed to A Smart.

6 recordsLinked to original sources

Depression and 'hassles' in globus pharyngis.

A group of 25 patients (16 women, 9 men) attending an ENT department with globus sensation and 25 matched ENT controls were assessed using the Beck Depression Inventory and scales for daily stressful events ('hassles'). Globus patients of both sexes were significantly more depressed than controls and had Beck scores suggestive of significant depression. Thirteen patients, but only two controls, had an independent life event within two months of disease onset, and patients had higher hassles scores than controls.

Adult

Eukaryotic DNA methylases and their use for in vitro methylation.

DNA methylases from mouse and pea have been purified and characterized. Both are high molecular mass enzymes that show greater activity with hemimethylated than unmethylated substrate DNA. Both methylate cytosines in CpG preferentially, but not exclusively and show similar kinetics of methylation, which makes it difficult to saturate all possible sites on the DNA, but procedures are described that circumvent this problem.

Animals

Public health. Surma: a cause for concern.

Andrew Smart and Nishi Madan describe a campaign in Derby to reduce the use within Asian communities of 'surma', a lead-based eye cosmetic, and to raise awareness among health professionals of the potential hazard this practice presents. A health visitor may bring special insight to questions about traditions and customs pertaining to her client community and about which little may be known by those who do not have a close working relationship with those communities.

Adult

Impaired sweating in the diabetic neuropathic foot and its influence on skin flora.

Three groups each of 10 subjects, were defined by clinical and neurophysiological studies: diabetic with neuropathy (Group A), diabetic without neuropathy (Group B) and normal control (Group C). Sweating on the foot was quantified and the bacterial flora on the dorsum of the foot and deltoid area were examined. There were no significant differences in type of density of bacterial species found on either foot or deltoid regions between any of the three groups. Diabetics free of clinical infection have a similar skin microbial flora to non-diabetics even when sweating is seriously impaired. It is therefore unlikely that a change in the resident microbial flora is involved in the propensity of diabetic neuropathic patients to foot ulceration and infection.

Actinomycetales