Biomedical subjects
Publications and source records attributed to A Sokól.
It has been found that cationic protein breakdown product--3H-L-arginine labelled peptide fraction--interacts with fibrinogen in the presence of thrombin. The formation of the fibrin clot under these conditions makes the clot resistant to the fibrinolytic action of plasmin.
With the use of 3H-arginine labelled cationic proteins derived from fibrosarcoma induced by methylcholanthrene it has been shown in studies in vitro that these proteins interact with fibrinogen under the influence of thrombin. The effect of this reaction depends on the concentration of cationic proteins. it was calculated that 1 mg of fibrinogen can be interacted with 2.5 micrograms of 3H-arginine labelled cationic proteins. The clinical role of cationic proteins appearing in circulation in malignancy have been discussed briefly.
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