PubMed Health⌕ Search

Biomedical subjects

A Spengler

Publications and source records attributed to A Spengler.

At least 19 recordsLinked to original sources
PubMed2001

The glutathione peroxidase homologous gene from Chlamydomonas reinhardtii is transcriptionally up-regulated by singlet oxygen.

The glutathione peroxidase homologous gene (Gpxh gene) in Chlamydomonas reinhardtii is up-regulated under oxidative stress conditions. The Gpxh gene showed a remarkably strong and fast induction by the singlet oxygen-generating photosensitizers neutral red, methylene blue and rose Bengal. The Gpxh mRNA levels strongly increased, albeit much more slowly, upon exposure to the organic hydroperoxides tert-butyl hydroperoxide (t-BOOH) and cumene hydroperoxide. In contrast, the Gpxh mRNA levels were only weakly induced by exposure to the superoxide-generating compound paraquat and by hydrogen peroxide. A comparison of the Gpxh mRNA levels with those of the heat shock protein HSP70A and the iron superoxide dismutase gene showed qualitative and quantitative differences for the three genes under oxidative stress conditions tested. The Gpxh gene is specifically induced by singlet-oxygen photosensitizers and the relative induction by other compounds is much weaker for Gpxh than for the other genes investigated. Using Gpxh promoter fusions with the arylsulfatase reporter gene, we have shown that the Gpxh was transcriptionally up-regulated by singlet-oxygen photosensitizers. It is also shown that the Gpxh promoter contains a region between 104 and 179 bp upstream of the transcription start that is responsible for the mRNA up-regulation upon exposure to 1O2 but not t-BOOH. Within this region a regulatory sequence homologous to the mammalian cAMP response element (CRE) and activator protein 1 (AP-1) binding site was identified within a 16 bp palindrome.

Algal Proteins↗
PubMed1994

[Immediate compulsory commitment in Germany, 1991-1992: initial results].

The rates of compulsory admission and detention for 1991-1992 were provided by 32 German psychiatric hospitals and departments. Very low rates were found in the eastern states and wide variation in rate in the western (as in 1984). In 1991-1992 the median value for compulsory admission was 28.8 and for detention during the course of in-patient treatment 10.0 per 100,000 inhabitants per year.

Commitment of Persons with Psychiatric Disorders↗
PubMed1992

[Intuitive prognostic assessment in rehabilitation of long-term psychiatric patients].

The significance of intuitive prognostic assessments by the nursing staff and the examining female doctor is studied with regard to the course and results of "late rehabilitation" of 30 psychiatric patients who had been hospitalised for many years. Using standardised assessment criteria and catamnestic data on readmission as inpatients (covering a period of 20 months) patients were compared who had been discharged from the psychiatric hospital, transferred to long-term residential quarters, and assessed before discharge as likely or unlikely to be readmitted to the hospital. The group of patients who had been given an unfavourable prognosis--most of them women--proved in course of time to be readmitted as inpatients more often and to be significantly more disturbed than the patients who had been discharged with a more favourable prognosis. These results are discussed with regard to sociopolitical and medical care aspects and to approaches for further research in this direction.

Activities of Daily Living↗
PubMed1988

[Psychosexual disorders following genital operations in urology].

Psychosexual and functional disorders following genital surgery can be understood within the context of general adaptation/maladaptation with severe illness and cancer. The psychodynamics and phases of psychic crises are described. Genital surgery injures sexual identity. The specific sexual consequences are psychosexual disorders such as avoidance, inappetence, specific anxieties, and functional disorders. As etiologic factors, unspecific psychogenic effects, more individual psychogenic symptomatology, and specific physical impairment of sexual functions overlap, in accordance to type of illness and surgery. These aspects are demonstrated by clinical problems. The consequences for psychological counselling and information of patients are discussed.

Erectile Dysfunction↗
PubMed1983

[Treatment indications in psychiatric emergencies].

6 investigators of a "Psychiatric Emergency Service" recorded 299 outpatient emergency cases which required immediate involuntary admission in accordance with a new Hamburg Civil Law. To identify the factors exercising an influence on the indication for involuntary admission, the 299 interventions were compared resulting in outpatient treatment (n = 93) vs. voluntary admission (n = 84) vs. involuntary admission (n = 122). It was shown that the factors "diagnosis", "hazard", and, in particular, the interaction between patient and emergency physician, mainly determine the indication. The interactions of these factors are differentiated in detail, with respect to age, sex, and social factors.

Adolescent↗
PubMed1982

[Couple therapy in the presence of severe physical disability--a case example (author's transl)].

A case report is presented describing the possible applications of couple therapy (Masters/Johnson) in couples where a severe physical disability is present, beyond disturbances of sexual functioning. In the instance reported, a severe sexual aversion was present in the wife, with disturbances of excitation and orgasm, while the husband was paralysed due to adult poliomyelitis affecting his entire trunk and limbs. Based on the course of therapy and its outcome, the author discusses the specific problems and potentialities of this type of therapeutic intervention.

Adult↗
PubMed1981

[Initial experiences in psychiatric emergency service. Comments on the prevention or indication of compulsory hospitalization in accordance with the Hamburg Law on Aid and Protective Measures in Mental Diseases (author's transl)].

On the basis of the rules of the Hamburg Law on Aid and Protective Measures in Mental Diseases, a psychiatric emergency service operates at night and on weekends. This emergency service is called upon to decide on the need for compulsory hospitalization and to prevent the same, if possible, via therapeutic alternatives. The article illustrates by documents an initial phase of the activities of this public service. Within the framework of a preliminary study, 63 recorded incidents of service by four physicians are presented who collected data on the situation encountered by them at the time of examination, on the social and anamnestic background of the patients, on their psychiatric evaluation and on the indication for compulsory hospitalization or alternative treatment methods. 22% of the patients were subjected to compulsory hospitalization. Provisional hypotheses on the conditions under which compulsory hospitalization becomes more probable, are developed from the recorded data. The concept of the risk situation is specially reflected upon. The therapeutic possibilities in connection with institutional factors are discussed with a view to promote further development of crisis intervention in the sense of preventing compulsory hospitalization.

Commitment of Persons with Psychiatric Disorders↗