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Biomedical subjects

A Staudach

Publications and source records attributed to A Staudach.

At least 19 recordsLinked to original sources

[Comparison of biochemical and Doppler sonographic monitoring of high-risk pregnancies].

We performed in 113 patients at least three simultaneous determinations of serum-HPL and oestriol in 24-hour urine samples, as well as Doppler flow studies at the arcuate artery (AA), umbilical artery (UA), foetal aorta and internal carotid, because of suspicion of IUGR. The diagnostic value was studied with regard to IUGR, placental weight and mode of delivery. Concerning the detection of IUGR, the superiority of Doppler parameters (AA, UA) is shown. In the total number of patients, the rates for sensitivity and specificity for UA (78/91%) and AA (58/89%) exceed the hormone parameters. Oestriol, in particular, (13/63%) shows a marked difference, but even HPL (37/63%) cannot compete with respect to diagnostic value.

Acidosis

[The significance of computed tomography and ultrasound in the diagnosis of puerperal ovarian vein thrombophlebitis].

The diagnosis of puerperal ovarian venous thrombophlebitis (POVT) is problematic, not only because of the low and variable incidence (1:600-6000 births), but also because there are no characteristic clinical symptoms. So far, therefore in 80% of cases it has been diagnosed by exploratory laparatomy. Early non-invasive diagnostic procedures must be aimed at, because surgical intervention involves a high rate of complications and uncomplicated cases can be treated by conservative methods (broad-spectrum antibiotics and anti-coagulants). Several case reports refer to the possibility of recognizing POVT by real-time ultrasound (US) and computer tomography (CT). Two cases are described to illustrate this option for preoperative diagnosis by CT and US. A tubular, annular structure with ring enhancement after application of dye along the anatomical course of the ovarian vein seems to be characteristic for POVT.

Adult

[Diagnosis of fetal thrombocyte count in relation to obstetric management of maternal idiopathic thrombocytic purpura (Werlhof disease)].

Beside maternal, fetal platelet count is the essential parameter for the decision about the obstetrical management in ITP-patients in pregnancy. Evaluation of fetal platelet count contains different problems. Using heparinised capillary tubes in fetal blood sampling procedure, platelet aggregation occurs and therefore false low platelet counts are found, by the commonly used method of conductivity measurement. A recently observed case is reported.

Adult

[Doppler examination as an indication for surgical delivery. A case report].

Pathological alterations in foetoplacental circulation can lead to zero flow or even to reverse flow in the diastole. In these cases, a high fetal risk can be expected. Based on our Doppler measurements, we recommend by zero flow in the umbilical artery or foetal aorta, that the childbirth could be postponed under an observant attitude using intensive controls (CTG, foetal movements), but pregnancy has to be terminated immediately by Caesarean section at the first sign of reverse flow.

Adolescent

[Clinical value of a decrease in diastolic flow in obstetric Doppler sonography].

Doppler ultrasound in obstetrics is being increasingly accepted in foetal surveillance. For clinical practice, a good correlation between Doppler findings and biochemical data such as blood gas analysis and lactate as a metabolical parameter, would be desirable. To clarify this question, these results have to be compared. Prepartal Doppler results which are correlated with postpartal blood gas analyses of umbilical vessels cannot be a satisfactory criterion due to the influence of labour on these parameters. Therefore, we depend on results from foetal blood sampling procedure. The five cases presented here should be a contribution to this discussion. In summary it can be concluded, that in cases of a highly pathological Doppler analysis in the umbilical artery, intrauterine growth retardation must be expected. If there is an acidosis in the foetal organism, it can be assessed via the foetal carotid findings. This, therefore is our contribution to the discussion on the indication for Caesarean section in cases of absent diastolic flow: Absence of diastolic flow in the umbilical artery and foetal aorta only without centralisation by increased perfusion in the foetal carotid, is, in our opinion, not an indication for Caesarean section. We believe, that foetal acidosis confirmed by foetal blood gas analysis indicated by the Doppler result, is an efficient completion of obstetrical management in risk pregnancies. Any further decision on conservative management or termination of pregnancy can be taken more easily on the basis of biochemical data, especially in situations, where conventional methods of foetal surveillance cannot clarify the perinatal risk sufficiently.

Adolescent

[The course of pregnancy in lupus anticoagulant syndrome].

More than 95 per cent of the pregnancies with circulating lupus anticoagulant (LA) without therapy lead to abortion or intrauterine death. We report on the course of a pregnancy in a patient, who developed deep venous thrombosis and circulating LA. One of the rare cases of successful pregnancy management without the common prednisolone-aspirin therapy, but with heparin-monotherapy associated with intensive medical and obstetrical surveillance under clinical conditions is reported. In spite of intermittent corticosteroid and immunoglobulin application, a healthy child was born, although normalisation of the aPTT and platelet count was not achieved. It seems, that an alternative concept of therapy may have been established.

Autoantibodies