[Methodology and value of percutaneous transhepatic bile duct drainage].
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Biomedical subjects
Publications and source records attributed to A Steudel.
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A 41-year-old patient with latent porphyria cutanea tarda is described; 8 years after mastectomy for carcinoma, sonography and CT showed multiple hepatic foci, which were at first interpreted as liver metastases. A liver biopsy was carried out during laparoscopy and u/v fluorescence and subsequent laboratory tests confirmed the diagnosis of porphyria cutanea tarda. Treatment with resochin produced almost complete resolution of the liver abnormalities within 9 months. Magnetic resonance tomography using proton-weighted SE sequences showed a few foci of high signal intensity.
A retrospective study of 161 patients with carcinomas of the bladder was carried out to assess the value of CT (247 examinations), transurethral sonography (32 examinations), and the early results of MRT. For TA-T3a staging, according to the TNM classification of the IUCC, transurethral sonography was particularly valuable. CT is useful for demonstrating transmural tumour growth (T3b) and organ invasion (T4), involvement of regional lymph nodes and distant metastases. Tumours in the roof of the bladder and at its base are well shown by MR tomography, using multiplanar sections.
118 examinations were carried out for non-tumorous diseases of the brain and cervical cord. The sensitivity of MRT was analysed and compared with 77 cases where CT had been performed or with sonography in children. MRT showed an abnormality in 80%, whereas CT or sonography lead to a diagnosis in only 43%. Because of the significantly higher sensitivity of MRT, this should be the primary means of examination for this type of case.
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The signs of arterio-venous fistulae in the extremities have been evaluated by DSA in 20 patients. Angiographic signs for the presence of A-V fistulae are the following findings: dilatation of the supplying artery, elongation of the supplying artery, solitary A-V aneurysm, angiomatous A-V aneurysm, reduced blood flow distal to the A-V fistula, early venous filling, development of a venous collateral circulation and demonstration of retrograde venous flow. Angiography remains the method of choice for demonstrating A-V fistulae.
In 62 patients spinecho or gradientecho sequences compensated for motion were compared with corresponding non-compensated sequences. Compensation during MRT reduces those artifacts which are caused by regular motion. This is particularly effective during examination of the brain stem, spinal canal and the heart. The improved demonstration of the morphology of normal and diseases organs simplifies the analysis of the types of movement.
MR tomography of the liver using 1.5 T has been carried out in 63 patients with focal lesions in order to demonstrate haemangiomas and to differentiate these from primary and secondary malignant liver tumours. This differentiation was possible in all patients, using conventional spin echo and inversion recovery sequences in combination with sonography. Accuracy was much less good when using gradient echo sequences. With sufficiently large tumours, measurement of relaxation time made possible diagnosis of all the 22 haemangiomas.
Bilateral cardiac myxomas are very rare and therefore mostly overlooked. In most cases the diagnosis has been made intraoperatively or at postmortem examination. We report on a 60-year-old woman with a left atrial and right ventricular myxoma where diagnosis was made by echocardiography and computer tomography, and confirmed histologically after successful surgical and therapeutic aspects are discussed.
In idiopathic hemochromatosis, there is progressive deposition of iron in parenchymatous organs owing to a defect in iron absorption the nature of which is not so far known. This can result in cardiomyopathy with heart failure and arrhythmia which are refractory to therapy. Nuclear magnetic resonance tomography is a specific imaging technique for early detection of myocardial iron deposits. With quantitative determination of the T2 relaxation time of the myocardium, a progress control under venesection therapy is possible above and beyond diagnostics.
Indications and the diagnostic value of radiological investigation methods in thoracic aortoaneurysm are reported. The suspected diagnosis can already be made on the basis of conventional x-ray examination of the thorax. Computer tomography (CT) with i.v. administration of contrast medium allows unequivocal identification of a mediastinal space occupation as an aneurysm. However, preoperative angiography is indispensable in many cases for appraisal of the vessel origins. Depending on the condition to be investigated, digital subtraction angiography (DSA) which is carried out with i.v. or i.a. injection of contrast medium has replaced conventional angiography here. Nuclear magnetic resonance tomography has only minor importance so far despite the good imaging of the aorta.
Contrast performance in MR tomography is influenced by the choice of technical parameters such as pulse repetition time (TR), echo time (TE) and inversion time (TI) in the same manner as by differences in the tissue parameters relaxation time and proton density. To optimise image contrast it is therefore suggested to preselect the imaging sequence. Such presselection is possible on the basis of isosignal visualisations S(T1, T2). In the inversion recovery sequence (IR) the isosignal images obtained with the parameters TE, TI, TR enable determination of relaxation time T1 by graphic representation, from the time of zero passage of the longitudinal tissue magnetisation.
ECG-triggered cardio-MRT, using T1-weighted SE sequences, provides images of the heart showing very high anatomical resolution. So far, however, it has not been possible to demonstrate the morphology of the valves and coronary vessels. By using multiplanar sections, it is possible to obtain cuts which are perpendicular to the portion of myocardium or valve under consideration. This provides optimal imaging for morphological diagnosis and for evaluating the ventricular myocardium and its function.
The place of MRT, using surface coils, has been evaluated retrospectively in 27 patients with clinically confirmed malignant tumours of the mouth and pharynx. The extent of the tumour and its relationship to neighbouring structures is well demonstrated. The resolution obtainable by using surface coils is almost as good as that of CT. Soft tissue contrast is better in showing the spread and size of the tumour. A disadvantage of MRT is the inability in most cases to demonstrate bone destruction. Differentiation between residual tumour, recurrence and scarring is possible only occasionally. Quantitative MRT may be expected to lead to improved diagnosis during the course of following up.
Two hundred and twenty-six patients with haemophilia A and B were examined by CT. In 135 cases, some form of bleeding was demonstrated. CT permits exact anatomical localisation of the haematoma and its delineation from neighbouring structures. Measurements of the densities of the haematomas make it possible to determine their age from the change in absorption values. Computed tomography makes it easier for the clinician to choose between conservative or surgical treatment and to determine the duration of treatment during the regression of the haematoma.
Thirty-eight MRT examinations were carried out in 35 patients who, between them, had 19 abnormalities in the adrenal glands. These included ten adenomas, three metastases, two carcinomas, two phaeochromocytomas, and two primary retroperitoneal tumours. MRT provides images of normal and abnormal adrenal glands which are equivalent to those of CT, with the exception that it cannot demonstrate calcification. Using a ratio of signal intensity from the adrenal tumours and the liver on T2-weighted images, it is usually possible to differentiate adenomas from metastases, carcinomas or phaeochromocytomas. The increased specificity of MRT is valuable in the investigation of patients with asymptomatic enlargement of the adrenal glands.
The fast-field-echo (FFE) sequence provides a new rapid imaging method for MR tomography. By using gradient echoes with shorter high frequency pulse repetitions than conventional sequences with 180 degrees echo pulses, it is possible to produce single cuts in 10 to 20 s with good signal-to-noise ratio. In this way the liver can be examined while respiratory movement artifacts are reduced. The possibility of obtaining T1- and T 2-weighted FFE images with good contrast resolution and the ability to determine relaxation times suggests a wide application of this rapid imaging procedure in the diagnosis of liver disease.
The results obtained by MR tomography in 30 patients after renal grafting are compared with the clinical and histological data in respect of corticomedullary contrast (CMC). In 22 patients with regular functioning of the transplant the CMC was normal at 19.4%. Eight MR examinations yielded a clearly reduced CMC below 14%. In 7 of these 8 patients it was possible to prove histologically the existence of an acute tubular necrosis or of a transplant rejection. Noninvasive MR tomography yielded an early indication for treating the acute renal transplant rejection without being able to differentiate between such a rejection and acute renal failure.