Biomedical subjects

A Stork

Publications and source records attributed to A Stork.

At least 19 recordsLinked to original sources

PubMed1977

Relationship of age and sex to postheparin esterase activity.

Postheparin esterase (E. C. 3.1.1.1.) activity was studied in 130 women and 126 men in whom the medical findings were consistent with their age. The test subjects were divided into 5 age groups from 17 to 73 years. Postheparin esterase activity was found to be statistically significantly higher in men than in women. In men it was uncorrelated to age, while in women it rose with advancing age. Changes in postheparin esterase in women appear to be correlated to the hormonal state of the organism.

Adolescent↗

PubMed1977

Inhibition of lipolysis by oxytocin and vasopressin.

The administration of 5 I. U. oxytocin (by quick infusion) or of 5 I. U. vasopressin-lysine (intramuscularly) to healthy subjects was followed by a significant decrease in the plasma non-esterified fatty acid level. We regard this as evidence of inhibition of basal lipolysis in the adipose tissue. Vasopressin also completely blocked an increase induced in the plasma non-esterified fatty acid level by activating hormone-sensitive lipase in the adipose tissue by the infusion of 0.5 mg noradrenaline.

Fatty Acids, Nonesterified↗

PubMed1977

Trehalase activity in diabetes mellitus and in cirrhosis of the liver.

Trehalase (an enzyme decomposing the disaccharide trehalose) activity was studied in 29 healthy subjects, 25 patients with cirrhosis and 112 diabetics. Mean trehalase activity was 176 +/- 11 units in the control group, 647 +/- 421 units in the patients with cirrhosis and 467 +/- 239 units in diabetics. The differences between the control group on the one hand and the groups with cirrhosis and diabetes on the other were statistically significant. The results show that the organism, under pathological conditions, makes far greater use of its enzymatic apparatus to assure its basic requirements, but the scatter of the values is so great that the determination of trehalase has no discriminative value in individual cases.

Aged↗

PubMed1977

Changes in postheparin lipolytic activity in liver diseases.

The activity of the lipolytic enzymes lipoprotein lipase and postheparin esterase is inhibited in chronic liver diseases and postheparin esterase activity is often practically zero. In acute liver diseases postheparin esterase activity is low, but returns to normal as the patient recovers. Its determination can therefore be used to evaluate the course of the disease. The administration of sex hormones (testosterone) is followed in cirrhotic patients by a percentually significantly higher increase in postheparin esterase activity than in healthy subjects.

Esterases↗

PubMed1977

Cytological picture of altered activity of the lipolytic enzymes.

The onset, culmination and involution of ovarian incretory function are reflected very sensitively in the hormonal colpocytological pattern. Disturbances of ovarian hormone production are associated with changes in lipid metabolism. The alpha-lipoprotein concentration falls and the beta-lipoprotein concentration rises. Postheparin esterase (PHE) and lipoprotein lipase (LPL) activity significantly influence the ovarian steroids. Oestrogens cause elevation of colpocytological oestrogenic indexes and lower PHE values. After the administration of testosterone in old age, the vaginal picture reacts by intermediary proliferation. PHE activity reacts by an increase. Like steroids, the enzymes PHE and LPL have a relationship to the liver cell. In cirrhosis the hormonal situation of the organism changes. The cytological picture in women after the menopause displays signs of proliferation, women in the childbearing period are hyperoestrogenic and PHE activity is low.

Atrophy↗

PubMed1976